Coordinated Biosynthesis of the Purine Nucleoside Antibiotics Aristeromycin and Coformycin in Actinomycetes

Purine nucleoside antibiotic pairs, concomitantly produced by a single strain, are an important group of microbial natural products. Here, we report a target-directed genome mining approach to elucidate the biosynthesis of the purine nucleoside antibiotic pair aristeromycin (ARM) and coformycin (COF...

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Veröffentlicht in:	Applied and environmental microbiology 2018-11, Vol.84 (22)
Hauptverfasser:	Xu, Gudan, Kong, Liyuan, Gong, Rong, Xu, Liudong, Gao, Yaojie, Jiang, Ming, Cai, You-Sheng, Hong, Kui, Hu, Youcai, Liu, Peng, Deng, Zixin, Price, Neil P J, Chen, Wenqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetes Adenosine Adenosine deaminase Antibiotics Biosynthesis Combinatorial analysis Genetics and Molecular Biology Genomes GMP reductase IMP dehydrogenase Microorganisms NADP Natural products Nucleosides Organic chemistry Phosphorylases Salvage
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