Effects of muscle cooling on kinetics of pulmonary oxygen uptake and muscle deoxygenation at the onset of exercise
This study investigated effects of skeletal muscle cooling on the metabolic response and kinetics of pulmonary oxygen uptake (V˙O2) and skeletal muscle deoxygenation during submaximal exercise. In the cooling condition (C), after immersion of the lower body into 12°C water for 30 min, eight healthy...
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| creator | Wakabayashi, Hitoshi Osawa, Mizuki Koga, Shunsaku Li, Ke Sakaue, Hiroyuki Sengoku, Yasuo Takagi, Hideki |
| description | This study investigated effects of skeletal muscle cooling on the metabolic response and kinetics of pulmonary oxygen uptake (V˙O2) and skeletal muscle deoxygenation during submaximal exercise. In the cooling condition (C), after immersion of the lower body into 12°C water for 30 min, eight healthy males performed 30‐min cycling exercise at the lactate threshold while undergoing thigh cooling by a water‐circulating pad. In the normal condition (N) as control, they conducted the same exercise protocol without cooling. Blood lactate concentration was significantly higher in C than N at 10 min after onset of exercise (4.0 ± 1.7 and 2.4 ± 1.2 mmol/L in C and N, P |
| doi_str_mv | 10.14814/phy2.13910 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6209689</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2133339055</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5620-65bb5f815538ff03e7288226e2ddd4e098fd66239deea7b2cfbf767d6b96a3a23</originalsourceid><addsrcrecordid>eNp9kc9rFDEUx4Mgtmx78i4BL4JszY_5kVwEKdUWCnpQ0FPIJC-7aWeScZKp3f_e7E5b1IOnHN7nffLe-yL0kpIzWglavRu3O3ZGuaTkGTpmpKZrQdvvR-g0pRtCCCWcS1K9QEeccEGFrI7RdOEcmJxwdHiYk-kBmxh7HzY4BnzrA2RvDtVx7ocY9LTD8X63gYDnMetbwDrYx04LS0lnX5p1xnkLRZMg7wVwD5PxCU7Qc6f7BKcP7wp9-3jx9fxyff3509X5h-u1qRtG1k3ddbUTtK65cI5waJkQjDXArLUVECmcbRrGpQXQbceM61zbtLbpZKO5ZnyF3i_ece4GsAZCnnSvxskPZQsVtVd_V4Lfqk28U-V32QhZBG8eBFP8OUPKavDJQN_rAHFOilHWyprRWhT09T_oTZynUNYrFOf7u5c9VujtQpkppjSBexqGEnWIUO0jVIcIC_3qz_mf2MfwCsAW4JfvYfc_l_py-YMt1t9aeasD</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2133339055</pqid></control><display><type>article</type><title>Effects of muscle cooling on kinetics of pulmonary oxygen uptake and muscle deoxygenation at the onset of exercise</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Wakabayashi, Hitoshi ; Osawa, Mizuki ; Koga, Shunsaku ; Li, Ke ; Sakaue, Hiroyuki ; Sengoku, Yasuo ; Takagi, Hideki</creator><creatorcontrib>Wakabayashi, Hitoshi ; Osawa, Mizuki ; Koga, Shunsaku ; Li, Ke ; Sakaue, Hiroyuki ; Sengoku, Yasuo ; Takagi, Hideki</creatorcontrib><description>This study investigated effects of skeletal muscle cooling on the metabolic response and kinetics of pulmonary oxygen uptake (V˙O2) and skeletal muscle deoxygenation during submaximal exercise. In the cooling condition (C), after immersion of the lower body into 12°C water for 30 min, eight healthy males performed 30‐min cycling exercise at the lactate threshold while undergoing thigh cooling by a water‐circulating pad. In the normal condition (N) as control, they conducted the same exercise protocol without cooling. Blood lactate concentration was significantly higher in C than N at 10 min after onset of exercise (4.0 ± 1.7 and 2.4 ± 1.2 mmol/L in C and N, P < 0.05). The percent change in the tissue oxygen saturation of the vastus lateralis, measured by a near‐infrared spectroscopy, was significantly lower in C at 2, 8, 10, and 20 min after the exercise onset compared with N (P < 0.05). The percent change in deoxy hemoglobin+myoglobin concentration (Deoxy[Hb+Mb]) showed a transient peak at the onset of exercise and significantly higher value in C at 10, 20, and 30 min after the exercise onset (P < 0.05). Compared to N, slower V˙O2 kinetics (mean response time) was observed in C (45.6 ± 7.8 and 36.1 ± 7.7 sec in C and N, P < 0.05). The mean response time in C relative to N was significantly correlated with the transient peak of Deoxy[Hb+Mb] in C (r = 0.84, P < 0.05). These results suggest that lower oxygen delivery to the hypothermic skeletal muscle might induce greater glycolytic metabolism during exercise and slower V˙O2 kinetics at the onset of exercise.
This study investigated how muscle cooling affects the metabolism of the working muscle and pulmonary oxygen uptake kinetics at the onset of exercise. The major finding is that with muscle cooling the transient peak in muscle deoxygenation, reflecting less oxygen delivery relative to oxygen demand, is associated with slowing of oxygen uptake kinetics at the onset of exercise.</description><identifier>EISSN: 2051-817X</identifier><identifier>DOI: 10.14814/phy2.13910</identifier><identifier>PMID: 30381894</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Adult ; Blood levels ; Cold skeletal muscle ; Cooling ; Exercise ; Glycolysis ; glycolytic metabolism ; Hemoglobin ; Hemoglobins - analysis ; Humans ; Hypothermia, Induced - adverse effects ; Hypothermia, Induced - methods ; Infrared spectroscopy ; Lactic acid ; Lactic Acid - blood ; Male ; Metabolic response ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - physiology ; Musculoskeletal system ; Myoglobin - blood ; Myoglobins ; near‐infrared spectroscopy ; Original Research ; Oxygen ; Oxygen Consumption ; Physiology ; Pulmonary Gas Exchange ; Skeletal muscle</subject><ispartof>Physiological reports, 2018-11, Vol.6 (21), p.e13910-n/a</ispartof><rights>2018 The Authors. published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society</rights><rights>2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5620-65bb5f815538ff03e7288226e2ddd4e098fd66239deea7b2cfbf767d6b96a3a23</citedby><cites>FETCH-LOGICAL-c5620-65bb5f815538ff03e7288226e2ddd4e098fd66239deea7b2cfbf767d6b96a3a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209689/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209689/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11542,27903,27904,45553,45554,46030,46454,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30381894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wakabayashi, Hitoshi</creatorcontrib><creatorcontrib>Osawa, Mizuki</creatorcontrib><creatorcontrib>Koga, Shunsaku</creatorcontrib><creatorcontrib>Li, Ke</creatorcontrib><creatorcontrib>Sakaue, Hiroyuki</creatorcontrib><creatorcontrib>Sengoku, Yasuo</creatorcontrib><creatorcontrib>Takagi, Hideki</creatorcontrib><title>Effects of muscle cooling on kinetics of pulmonary oxygen uptake and muscle deoxygenation at the onset of exercise</title><title>Physiological reports</title><addtitle>Physiol Rep</addtitle><description>This study investigated effects of skeletal muscle cooling on the metabolic response and kinetics of pulmonary oxygen uptake (V˙O2) and skeletal muscle deoxygenation during submaximal exercise. In the cooling condition (C), after immersion of the lower body into 12°C water for 30 min, eight healthy males performed 30‐min cycling exercise at the lactate threshold while undergoing thigh cooling by a water‐circulating pad. In the normal condition (N) as control, they conducted the same exercise protocol without cooling. Blood lactate concentration was significantly higher in C than N at 10 min after onset of exercise (4.0 ± 1.7 and 2.4 ± 1.2 mmol/L in C and N, P < 0.05). The percent change in the tissue oxygen saturation of the vastus lateralis, measured by a near‐infrared spectroscopy, was significantly lower in C at 2, 8, 10, and 20 min after the exercise onset compared with N (P < 0.05). The percent change in deoxy hemoglobin+myoglobin concentration (Deoxy[Hb+Mb]) showed a transient peak at the onset of exercise and significantly higher value in C at 10, 20, and 30 min after the exercise onset (P < 0.05). Compared to N, slower V˙O2 kinetics (mean response time) was observed in C (45.6 ± 7.8 and 36.1 ± 7.7 sec in C and N, P < 0.05). The mean response time in C relative to N was significantly correlated with the transient peak of Deoxy[Hb+Mb] in C (r = 0.84, P < 0.05). These results suggest that lower oxygen delivery to the hypothermic skeletal muscle might induce greater glycolytic metabolism during exercise and slower V˙O2 kinetics at the onset of exercise.
This study investigated how muscle cooling affects the metabolism of the working muscle and pulmonary oxygen uptake kinetics at the onset of exercise. The major finding is that with muscle cooling the transient peak in muscle deoxygenation, reflecting less oxygen delivery relative to oxygen demand, is associated with slowing of oxygen uptake kinetics at the onset of exercise.</description><subject>Adult</subject><subject>Blood levels</subject><subject>Cold skeletal muscle</subject><subject>Cooling</subject><subject>Exercise</subject><subject>Glycolysis</subject><subject>glycolytic metabolism</subject><subject>Hemoglobin</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Hypothermia, Induced - adverse effects</subject><subject>Hypothermia, Induced - methods</subject><subject>Infrared spectroscopy</subject><subject>Lactic acid</subject><subject>Lactic Acid - blood</subject><subject>Male</subject><subject>Metabolic response</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - physiology</subject><subject>Musculoskeletal system</subject><subject>Myoglobin - blood</subject><subject>Myoglobins</subject><subject>near‐infrared spectroscopy</subject><subject>Original Research</subject><subject>Oxygen</subject><subject>Oxygen Consumption</subject><subject>Physiology</subject><subject>Pulmonary Gas Exchange</subject><subject>Skeletal muscle</subject><issn>2051-817X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc9rFDEUx4Mgtmx78i4BL4JszY_5kVwEKdUWCnpQ0FPIJC-7aWeScZKp3f_e7E5b1IOnHN7nffLe-yL0kpIzWglavRu3O3ZGuaTkGTpmpKZrQdvvR-g0pRtCCCWcS1K9QEeccEGFrI7RdOEcmJxwdHiYk-kBmxh7HzY4BnzrA2RvDtVx7ocY9LTD8X63gYDnMetbwDrYx04LS0lnX5p1xnkLRZMg7wVwD5PxCU7Qc6f7BKcP7wp9-3jx9fxyff3509X5h-u1qRtG1k3ddbUTtK65cI5waJkQjDXArLUVECmcbRrGpQXQbceM61zbtLbpZKO5ZnyF3i_ece4GsAZCnnSvxskPZQsVtVd_V4Lfqk28U-V32QhZBG8eBFP8OUPKavDJQN_rAHFOilHWyprRWhT09T_oTZynUNYrFOf7u5c9VujtQpkppjSBexqGEnWIUO0jVIcIC_3qz_mf2MfwCsAW4JfvYfc_l_py-YMt1t9aeasD</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Wakabayashi, Hitoshi</creator><creator>Osawa, Mizuki</creator><creator>Koga, Shunsaku</creator><creator>Li, Ke</creator><creator>Sakaue, Hiroyuki</creator><creator>Sengoku, Yasuo</creator><creator>Takagi, Hideki</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201811</creationdate><title>Effects of muscle cooling on kinetics of pulmonary oxygen uptake and muscle deoxygenation at the onset of exercise</title><author>Wakabayashi, Hitoshi ; Osawa, Mizuki ; Koga, Shunsaku ; Li, Ke ; Sakaue, Hiroyuki ; Sengoku, Yasuo ; Takagi, Hideki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5620-65bb5f815538ff03e7288226e2ddd4e098fd66239deea7b2cfbf767d6b96a3a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Blood levels</topic><topic>Cold skeletal muscle</topic><topic>Cooling</topic><topic>Exercise</topic><topic>Glycolysis</topic><topic>glycolytic metabolism</topic><topic>Hemoglobin</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Hypothermia, Induced - adverse effects</topic><topic>Hypothermia, Induced - methods</topic><topic>Infrared spectroscopy</topic><topic>Lactic acid</topic><topic>Lactic Acid - blood</topic><topic>Male</topic><topic>Metabolic response</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - physiology</topic><topic>Musculoskeletal system</topic><topic>Myoglobin - blood</topic><topic>Myoglobins</topic><topic>near‐infrared spectroscopy</topic><topic>Original Research</topic><topic>Oxygen</topic><topic>Oxygen Consumption</topic><topic>Physiology</topic><topic>Pulmonary Gas Exchange</topic><topic>Skeletal muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wakabayashi, Hitoshi</creatorcontrib><creatorcontrib>Osawa, Mizuki</creatorcontrib><creatorcontrib>Koga, Shunsaku</creatorcontrib><creatorcontrib>Li, Ke</creatorcontrib><creatorcontrib>Sakaue, Hiroyuki</creatorcontrib><creatorcontrib>Sengoku, Yasuo</creatorcontrib><creatorcontrib>Takagi, Hideki</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Physiological reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wakabayashi, Hitoshi</au><au>Osawa, Mizuki</au><au>Koga, Shunsaku</au><au>Li, Ke</au><au>Sakaue, Hiroyuki</au><au>Sengoku, Yasuo</au><au>Takagi, Hideki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of muscle cooling on kinetics of pulmonary oxygen uptake and muscle deoxygenation at the onset of exercise</atitle><jtitle>Physiological reports</jtitle><addtitle>Physiol Rep</addtitle><date>2018-11</date><risdate>2018</risdate><volume>6</volume><issue>21</issue><spage>e13910</spage><epage>n/a</epage><pages>e13910-n/a</pages><eissn>2051-817X</eissn><abstract>This study investigated effects of skeletal muscle cooling on the metabolic response and kinetics of pulmonary oxygen uptake (V˙O2) and skeletal muscle deoxygenation during submaximal exercise. In the cooling condition (C), after immersion of the lower body into 12°C water for 30 min, eight healthy males performed 30‐min cycling exercise at the lactate threshold while undergoing thigh cooling by a water‐circulating pad. In the normal condition (N) as control, they conducted the same exercise protocol without cooling. Blood lactate concentration was significantly higher in C than N at 10 min after onset of exercise (4.0 ± 1.7 and 2.4 ± 1.2 mmol/L in C and N, P < 0.05). The percent change in the tissue oxygen saturation of the vastus lateralis, measured by a near‐infrared spectroscopy, was significantly lower in C at 2, 8, 10, and 20 min after the exercise onset compared with N (P < 0.05). The percent change in deoxy hemoglobin+myoglobin concentration (Deoxy[Hb+Mb]) showed a transient peak at the onset of exercise and significantly higher value in C at 10, 20, and 30 min after the exercise onset (P < 0.05). Compared to N, slower V˙O2 kinetics (mean response time) was observed in C (45.6 ± 7.8 and 36.1 ± 7.7 sec in C and N, P < 0.05). The mean response time in C relative to N was significantly correlated with the transient peak of Deoxy[Hb+Mb] in C (r = 0.84, P < 0.05). These results suggest that lower oxygen delivery to the hypothermic skeletal muscle might induce greater glycolytic metabolism during exercise and slower V˙O2 kinetics at the onset of exercise.
This study investigated how muscle cooling affects the metabolism of the working muscle and pulmonary oxygen uptake kinetics at the onset of exercise. The major finding is that with muscle cooling the transient peak in muscle deoxygenation, reflecting less oxygen delivery relative to oxygen demand, is associated with slowing of oxygen uptake kinetics at the onset of exercise.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>30381894</pmid><doi>10.14814/phy2.13910</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Blood levels Cold skeletal muscle Cooling Exercise Glycolysis glycolytic metabolism Hemoglobin Hemoglobins - analysis Humans Hypothermia, Induced - adverse effects Hypothermia, Induced - methods Infrared spectroscopy Lactic acid Lactic Acid - blood Male Metabolic response Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Musculoskeletal system Myoglobin - blood Myoglobins near‐infrared spectroscopy Original Research Oxygen Oxygen Consumption Physiology Pulmonary Gas Exchange Skeletal muscle |
| title | Effects of muscle cooling on kinetics of pulmonary oxygen uptake and muscle deoxygenation at the onset of exercise |
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