A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder
In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7-13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological...
Gespeichert in:
| Veröffentlicht in: | Child development 2018-09, Vol.89 (5), p.1839-1855 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1855 |
|---|---|
| container_issue | 5 |
| container_start_page | 1839 |
| container_title | Child development |
| container_volume | 89 |
| creator | Barker, Edward D. Cecil, Charlotte A.M. Jaffee, Sara R. O'Connor, Thomas G. Meehan, Alan J. Walton, Esther Rowe, Richard Maughan, Barbara Stringaris, Argyris McArdle, Wendy Relton, Caroline L. Gaunt, Tom R. |
| description | In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7-13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong). |
| doi_str_mv | 10.1111/cdev.12957 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6207925</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>45046813</jstor_id><sourcerecordid>45046813</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4707-36ab94fec32157fae41a2d36c73b13c073c99df913a16c86b51ee2991d1ac4ef3</originalsourceid><addsrcrecordid>eNp9kc1uEzEUhS0EoqGwYQ-yxAYhTfHf_HiDlCaFIhVlQaFLy_HcaRxNxoPtDJpH4W3xNG0ELPDGuvJ3Px35IPSSkjOazntTw3BGmczLR2hGRVFmVcHEYzQjhMiMS0ZO0LMQtmlkheRP0QmrJJNCFjP0a46_QNyMrdtBdmNrwPMQnLE6Wtfhr3Ffj9g1-NrrLZjovIUwzau-d8FOjG7xEhqru4jPYaMH63zAuqvxuXWtu7UmAasBfKt7fGPjBs9jhO7OPu0ZG_Hl2IPXJtrBxhEvbXC-Bv8cPWl0G-DF_X2Kvn28uF5cZlerT58X86vMiJKUGS_0WooGDGc0LxsNgmpW88KUfE25ISU3UtaNpFzTwlTFOqcATEpaU20ENPwUfTh4-_16B7VJ4bxuVe_tTvtROW3V3y-d3ahbN6iCkVKyPAne3gu8-7GHENXOBgNtqztw-6CoFJRIIlmZ0Df_oFu39-kPg2KUEEFyXslEvTtQxrsQPDTHMJSoqXE1Na7uGk_w6z_jH9GHihNAD8BP28L4H5VaLC--P0hfHXa2IXV-3BE5EUVFOf8NHkHDug</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2100405389</pqid></control><display><type>article</type><title>A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>Education Source</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Barker, Edward D. ; Cecil, Charlotte A.M. ; Jaffee, Sara R. ; O'Connor, Thomas G. ; Meehan, Alan J. ; Walton, Esther ; Rowe, Richard ; Maughan, Barbara ; Stringaris, Argyris ; McArdle, Wendy ; Relton, Caroline L. ; Gaunt, Tom R.</creator><creatorcontrib>Barker, Edward D. ; Cecil, Charlotte A.M. ; Jaffee, Sara R. ; O'Connor, Thomas G. ; Meehan, Alan J. ; Walton, Esther ; Rowe, Richard ; Maughan, Barbara ; Stringaris, Argyris ; McArdle, Wendy ; Relton, Caroline L. ; Gaunt, Tom R.</creatorcontrib><description>In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7-13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).</description><identifier>ISSN: 0009-3920</identifier><identifier>EISSN: 1467-8624</identifier><identifier>DOI: 10.1111/cdev.12957</identifier><identifier>PMID: 28929496</identifier><language>eng</language><publisher>United States: Wiley for the Society for Research in Child Development</publisher><subject>Adolescent ; Anxiety ; Attention Deficit and Disruptive Behavior Disorders - complications ; Attention Deficit and Disruptive Behavior Disorders - genetics ; Attention Deficit and Disruptive Behavior Disorders - psychology ; Attention Deficit Disorder with Hyperactivity - complications ; Attention Deficit Disorder with Hyperactivity - genetics ; Attention deficit hyperactivity disorder ; Biological correlates ; Child ; Child development ; Childbirth & labor ; Cigarette smoking ; Cohort Studies ; Deoxyribonucleic acid ; DNA ; DNA Methylation ; Empirical ; EMPIRICAL ARTICLES ; Female ; Humans ; Irritable Mood ; Male ; Oppositional defiant disorder ; Prenatal care ; Prenatal experience ; Prenatal exposure ; Smoking ; Symptom Assessment</subject><ispartof>Child development, 2018-09, Vol.89 (5), p.1839-1855</ispartof><rights>2018 The Society for Research in Child Development, Inc.</rights><rights>2017 The Authors. Child Development published by Wiley Periodicals, Inc. on behalf of Society for Research in Child Development.</rights><rights>Child Development © 2018 The Society for Research in Child Development, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4707-36ab94fec32157fae41a2d36c73b13c073c99df913a16c86b51ee2991d1ac4ef3</citedby><cites>FETCH-LOGICAL-c4707-36ab94fec32157fae41a2d36c73b13c073c99df913a16c86b51ee2991d1ac4ef3</cites><orcidid>0000-0001-7169-997X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/45046813$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/45046813$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,1411,27901,27902,30976,45550,45551,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28929496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barker, Edward D.</creatorcontrib><creatorcontrib>Cecil, Charlotte A.M.</creatorcontrib><creatorcontrib>Jaffee, Sara R.</creatorcontrib><creatorcontrib>O'Connor, Thomas G.</creatorcontrib><creatorcontrib>Meehan, Alan J.</creatorcontrib><creatorcontrib>Walton, Esther</creatorcontrib><creatorcontrib>Rowe, Richard</creatorcontrib><creatorcontrib>Maughan, Barbara</creatorcontrib><creatorcontrib>Stringaris, Argyris</creatorcontrib><creatorcontrib>McArdle, Wendy</creatorcontrib><creatorcontrib>Relton, Caroline L.</creatorcontrib><creatorcontrib>Gaunt, Tom R.</creatorcontrib><title>A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder</title><title>Child development</title><addtitle>Child Dev</addtitle><description>In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7-13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).</description><subject>Adolescent</subject><subject>Anxiety</subject><subject>Attention Deficit and Disruptive Behavior Disorders - complications</subject><subject>Attention Deficit and Disruptive Behavior Disorders - genetics</subject><subject>Attention Deficit and Disruptive Behavior Disorders - psychology</subject><subject>Attention Deficit Disorder with Hyperactivity - complications</subject><subject>Attention Deficit Disorder with Hyperactivity - genetics</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Biological correlates</subject><subject>Child</subject><subject>Child development</subject><subject>Childbirth & labor</subject><subject>Cigarette smoking</subject><subject>Cohort Studies</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Methylation</subject><subject>Empirical</subject><subject>EMPIRICAL ARTICLES</subject><subject>Female</subject><subject>Humans</subject><subject>Irritable Mood</subject><subject>Male</subject><subject>Oppositional defiant disorder</subject><subject>Prenatal care</subject><subject>Prenatal experience</subject><subject>Prenatal exposure</subject><subject>Smoking</subject><subject>Symptom Assessment</subject><issn>0009-3920</issn><issn>1467-8624</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNp9kc1uEzEUhS0EoqGwYQ-yxAYhTfHf_HiDlCaFIhVlQaFLy_HcaRxNxoPtDJpH4W3xNG0ELPDGuvJ3Px35IPSSkjOazntTw3BGmczLR2hGRVFmVcHEYzQjhMiMS0ZO0LMQtmlkheRP0QmrJJNCFjP0a46_QNyMrdtBdmNrwPMQnLE6Wtfhr3Ffj9g1-NrrLZjovIUwzau-d8FOjG7xEhqru4jPYaMH63zAuqvxuXWtu7UmAasBfKt7fGPjBs9jhO7OPu0ZG_Hl2IPXJtrBxhEvbXC-Bv8cPWl0G-DF_X2Kvn28uF5cZlerT58X86vMiJKUGS_0WooGDGc0LxsNgmpW88KUfE25ISU3UtaNpFzTwlTFOqcATEpaU20ENPwUfTh4-_16B7VJ4bxuVe_tTvtROW3V3y-d3ahbN6iCkVKyPAne3gu8-7GHENXOBgNtqztw-6CoFJRIIlmZ0Df_oFu39-kPg2KUEEFyXslEvTtQxrsQPDTHMJSoqXE1Na7uGk_w6z_jH9GHihNAD8BP28L4H5VaLC--P0hfHXa2IXV-3BE5EUVFOf8NHkHDug</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Barker, Edward D.</creator><creator>Cecil, Charlotte A.M.</creator><creator>Jaffee, Sara R.</creator><creator>O'Connor, Thomas G.</creator><creator>Meehan, Alan J.</creator><creator>Walton, Esther</creator><creator>Rowe, Richard</creator><creator>Maughan, Barbara</creator><creator>Stringaris, Argyris</creator><creator>McArdle, Wendy</creator><creator>Relton, Caroline L.</creator><creator>Gaunt, Tom R.</creator><general>Wiley for the Society for Research in Child Development</general><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>8BJ</scope><scope>FQK</scope><scope>JBE</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7169-997X</orcidid></search><sort><creationdate>201809</creationdate><title>A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder</title><author>Barker, Edward D. ; Cecil, Charlotte A.M. ; Jaffee, Sara R. ; O'Connor, Thomas G. ; Meehan, Alan J. ; Walton, Esther ; Rowe, Richard ; Maughan, Barbara ; Stringaris, Argyris ; McArdle, Wendy ; Relton, Caroline L. ; Gaunt, Tom R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4707-36ab94fec32157fae41a2d36c73b13c073c99df913a16c86b51ee2991d1ac4ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Anxiety</topic><topic>Attention Deficit and Disruptive Behavior Disorders - complications</topic><topic>Attention Deficit and Disruptive Behavior Disorders - genetics</topic><topic>Attention Deficit and Disruptive Behavior Disorders - psychology</topic><topic>Attention Deficit Disorder with Hyperactivity - complications</topic><topic>Attention Deficit Disorder with Hyperactivity - genetics</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Biological correlates</topic><topic>Child</topic><topic>Child development</topic><topic>Childbirth & labor</topic><topic>Cigarette smoking</topic><topic>Cohort Studies</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Methylation</topic><topic>Empirical</topic><topic>EMPIRICAL ARTICLES</topic><topic>Female</topic><topic>Humans</topic><topic>Irritable Mood</topic><topic>Male</topic><topic>Oppositional defiant disorder</topic><topic>Prenatal care</topic><topic>Prenatal experience</topic><topic>Prenatal exposure</topic><topic>Smoking</topic><topic>Symptom Assessment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barker, Edward D.</creatorcontrib><creatorcontrib>Cecil, Charlotte A.M.</creatorcontrib><creatorcontrib>Jaffee, Sara R.</creatorcontrib><creatorcontrib>O'Connor, Thomas G.</creatorcontrib><creatorcontrib>Meehan, Alan J.</creatorcontrib><creatorcontrib>Walton, Esther</creatorcontrib><creatorcontrib>Rowe, Richard</creatorcontrib><creatorcontrib>Maughan, Barbara</creatorcontrib><creatorcontrib>Stringaris, Argyris</creatorcontrib><creatorcontrib>McArdle, Wendy</creatorcontrib><creatorcontrib>Relton, Caroline L.</creatorcontrib><creatorcontrib>Gaunt, Tom R.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>International Bibliography of the Social Sciences (IBSS)</collection><collection>International Bibliography of the Social Sciences</collection><collection>International Bibliography of the Social Sciences</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Child development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barker, Edward D.</au><au>Cecil, Charlotte A.M.</au><au>Jaffee, Sara R.</au><au>O'Connor, Thomas G.</au><au>Meehan, Alan J.</au><au>Walton, Esther</au><au>Rowe, Richard</au><au>Maughan, Barbara</au><au>Stringaris, Argyris</au><au>McArdle, Wendy</au><au>Relton, Caroline L.</au><au>Gaunt, Tom R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder</atitle><jtitle>Child development</jtitle><addtitle>Child Dev</addtitle><date>2018-09</date><risdate>2018</risdate><volume>89</volume><issue>5</issue><spage>1839</spage><epage>1855</epage><pages>1839-1855</pages><issn>0009-3920</issn><eissn>1467-8624</eissn><abstract>In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7-13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).</abstract><cop>United States</cop><pub>Wiley for the Society for Research in Child Development</pub><pmid>28929496</pmid><doi>10.1111/cdev.12957</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0001-7169-997X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-3920 |
| ispartof | Child development, 2018-09, Vol.89 (5), p.1839-1855 |
| issn | 0009-3920 1467-8624 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6207925 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); Jstor Complete Legacy; MEDLINE; Education Source; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Anxiety Attention Deficit and Disruptive Behavior Disorders - complications Attention Deficit and Disruptive Behavior Disorders - genetics Attention Deficit and Disruptive Behavior Disorders - psychology Attention Deficit Disorder with Hyperactivity - complications Attention Deficit Disorder with Hyperactivity - genetics Attention deficit hyperactivity disorder Biological correlates Child Child development Childbirth & labor Cigarette smoking Cohort Studies Deoxyribonucleic acid DNA DNA Methylation Empirical EMPIRICAL ARTICLES Female Humans Irritable Mood Male Oppositional defiant disorder Prenatal care Prenatal experience Prenatal exposure Smoking Symptom Assessment |
| title | A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T01%3A11%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Methylome-Wide%20Association%20Study%20of%20Trajectories%20of%20Oppositional%20Defiant%20Behaviors%20and%20Biological%20Overlap%20With%20Attention%20Deficit%20Hyperactivity%20Disorder&rft.jtitle=Child%20development&rft.au=Barker,%20Edward%20D.&rft.date=2018-09&rft.volume=89&rft.issue=5&rft.spage=1839&rft.epage=1855&rft.pages=1839-1855&rft.issn=0009-3920&rft.eissn=1467-8624&rft_id=info:doi/10.1111/cdev.12957&rft_dat=%3Cjstor_pubme%3E45046813%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2100405389&rft_id=info:pmid/28929496&rft_jstor_id=45046813&rfr_iscdi=true |