Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling

ABSTRACT Clinically, low and moderate alcohol intake improves human health with protection against metabolic syndromes, including type 2 diabetes; however, mechanisms that are associated with these effects remain to be elucidated. The aims of this study were to investigate the effects of moderate al...

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Veröffentlicht in:	The FASEB journal 2017-10, Vol.31 (10), p.4612-4622
Hauptverfasser:	Wang, Bo, Wang, Zhixiu, Avila, Jeanene M., Zhu, Mei‐Jun, Zhang, Faya, Gomez, Noe Alberto, Zhao, Liang, Tian, Qiyu, Zhao, Junxing, Maricelli, Joseph, Zhang, Hui, Rodgers, Buel D., Du, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes, Beige - drug effects Adipocytes, Beige - metabolism Adipogenesis Adipose tissue Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Adipose Tissue, White - drug effects Adipose Tissue, White - metabolism Alcohol use Alcoholic beverages Alcohols - pharmacology Aldehyde dehydrogenase beige adipocyte Body weight Body weight gain Diabetes mellitus Diabetes Mellitus, Type 2 - metabolism Diet, High-Fat fatty acids Glucose High fat diet Homeostasis Ion Channels - metabolism Lipid peroxidation Metabolic disorders Metabolism Mice Mitochondrial Proteins - metabolism obesity Obesity - metabolism Oxidation Platelet-derived growth factor Retinoic acid Rodents Signal Transduction - drug effects Signaling Thermogenesis Thermogenesis - drug effects Tretinoin - metabolism Uncoupling protein 1
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