Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling
ABSTRACT Clinically, low and moderate alcohol intake improves human health with protection against metabolic syndromes, including type 2 diabetes; however, mechanisms that are associated with these effects remain to be elucidated. The aims of this study were to investigate the effects of moderate al...
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| Veröffentlicht in: | The FASEB journal 2017-10, Vol.31 (10), p.4612-4622 |
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| creator | Wang, Bo Wang, Zhixiu Avila, Jeanene M. Zhu, Mei‐Jun Zhang, Faya Gomez, Noe Alberto Zhao, Liang Tian, Qiyu Zhao, Junxing Maricelli, Joseph Zhang, Hui Rodgers, Buel D. Du, Min |
| description | ABSTRACT
Clinically, low and moderate alcohol intake improves human health with protection against metabolic syndromes, including type 2 diabetes; however, mechanisms that are associated with these effects remain to be elucidated. The aims of this study were to investigate the effects of moderate alcohol intake on thermogenic brown/beige adipocyte formation and glucose and lipid homeostasis, as well as the involvement of retinoic acid (RA) signaling in the entire process. C57BL6 male mice were supplemented with 8% (w/v) alcohol in water for 1 or 4 mo. Alcohol intake prevented body weight gain, induced the formation of uncoupling protein 1–positive beige adipocytes in white adipose tissue, and increased thermogenesis in mice, which is associated with decreased serum glucose and triacylglycerol levels. Mechanistically, alcohol intake increased RA levels in serum and adipose tissue, which was associated with increased expression of aldehyde dehydrogenase family 1 subfamily A1 (Aldh1a1). When RA receptor‐α signaling was conditionally blocked in platelet‐derived growth factor receptor‐α‐positive adipose progenitors, the effects of alcohol on beige adipogenesis were largely abolished. Finally, moderate alcohol prevented high‐fat diet‐induced obesity and metabolic dysfunction. In conclusion, moderate alcohol intake induces thermogenic brown/beige adipocyte formation and promotes glucose and lipid oxidation via elevation of RA signaling.—Wang, B., Wang, Z., de Avila, J. M., Zhu, M.‐J., Zhang, F., Gomez, N. A., Zhao, L., Tian, Q., Zhao, J., Maricelli, J., Zhang, H., Rodgers, B. D., Du, M. Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling. FASEB J. 31, 4612–4622 (2017). www.fasebj.org |
| doi_str_mv | 10.1096/fj.201700396R |
| format | Article |
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Clinically, low and moderate alcohol intake improves human health with protection against metabolic syndromes, including type 2 diabetes; however, mechanisms that are associated with these effects remain to be elucidated. The aims of this study were to investigate the effects of moderate alcohol intake on thermogenic brown/beige adipocyte formation and glucose and lipid homeostasis, as well as the involvement of retinoic acid (RA) signaling in the entire process. C57BL6 male mice were supplemented with 8% (w/v) alcohol in water for 1 or 4 mo. Alcohol intake prevented body weight gain, induced the formation of uncoupling protein 1–positive beige adipocytes in white adipose tissue, and increased thermogenesis in mice, which is associated with decreased serum glucose and triacylglycerol levels. Mechanistically, alcohol intake increased RA levels in serum and adipose tissue, which was associated with increased expression of aldehyde dehydrogenase family 1 subfamily A1 (Aldh1a1). When RA receptor‐α signaling was conditionally blocked in platelet‐derived growth factor receptor‐α‐positive adipose progenitors, the effects of alcohol on beige adipogenesis were largely abolished. Finally, moderate alcohol prevented high‐fat diet‐induced obesity and metabolic dysfunction. In conclusion, moderate alcohol intake induces thermogenic brown/beige adipocyte formation and promotes glucose and lipid oxidation via elevation of RA signaling.—Wang, B., Wang, Z., de Avila, J. M., Zhu, M.‐J., Zhang, F., Gomez, N. A., Zhao, L., Tian, Q., Zhao, J., Maricelli, J., Zhang, H., Rodgers, B. D., Du, M. Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling. FASEB J. 31, 4612–4622 (2017). www.fasebj.org</description><identifier>ISSN: 0892-6638</identifier><identifier>EISSN: 1530-6860</identifier><identifier>DOI: 10.1096/fj.201700396R</identifier><identifier>PMID: 28679528</identifier><language>eng</language><publisher>United States: Federation of American Societies for Experimental Biology</publisher><subject>Adipocytes ; Adipocytes, Beige - drug effects ; Adipocytes, Beige - metabolism ; Adipogenesis ; Adipose tissue ; Adipose Tissue, Brown - drug effects ; Adipose Tissue, Brown - metabolism ; Adipose Tissue, White - drug effects ; Adipose Tissue, White - metabolism ; Alcohol use ; Alcoholic beverages ; Alcohols - pharmacology ; Aldehyde dehydrogenase ; beige adipocyte ; Body weight ; Body weight gain ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - metabolism ; Diet, High-Fat ; fatty acids ; Glucose ; High fat diet ; Homeostasis ; Ion Channels - metabolism ; Lipid peroxidation ; Metabolic disorders ; Metabolism ; Mice ; Mitochondrial Proteins - metabolism ; obesity ; Obesity - metabolism ; Oxidation ; Platelet-derived growth factor ; Retinoic acid ; Rodents ; Signal Transduction - drug effects ; Signaling ; Thermogenesis ; Thermogenesis - drug effects ; Tretinoin - metabolism ; Uncoupling protein 1</subject><ispartof>The FASEB journal, 2017-10, Vol.31 (10), p.4612-4622</ispartof><rights>FASEB</rights><rights>FASEB.</rights><rights>Copyright Federation of American Societies for Experimental Biology (FASEB) Oct 2017</rights><rights>FASEB 2017 FASEB</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428R-eec77f21e5ae2add6e5354eb4a416aea38848b0f429b983290fedcc971bf1f833</citedby><cites>FETCH-LOGICAL-c428R-eec77f21e5ae2add6e5354eb4a416aea38848b0f429b983290fedcc971bf1f833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1096%2Ffj.201700396R$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1096%2Ffj.201700396R$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28679528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Bo</creatorcontrib><creatorcontrib>Wang, Zhixiu</creatorcontrib><creatorcontrib>Avila, Jeanene M.</creatorcontrib><creatorcontrib>Zhu, Mei‐Jun</creatorcontrib><creatorcontrib>Zhang, Faya</creatorcontrib><creatorcontrib>Gomez, Noe Alberto</creatorcontrib><creatorcontrib>Zhao, Liang</creatorcontrib><creatorcontrib>Tian, Qiyu</creatorcontrib><creatorcontrib>Zhao, Junxing</creatorcontrib><creatorcontrib>Maricelli, Joseph</creatorcontrib><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Rodgers, Buel D.</creatorcontrib><creatorcontrib>Du, Min</creatorcontrib><title>Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling</title><title>The FASEB journal</title><addtitle>FASEB J</addtitle><description>ABSTRACT
Clinically, low and moderate alcohol intake improves human health with protection against metabolic syndromes, including type 2 diabetes; however, mechanisms that are associated with these effects remain to be elucidated. The aims of this study were to investigate the effects of moderate alcohol intake on thermogenic brown/beige adipocyte formation and glucose and lipid homeostasis, as well as the involvement of retinoic acid (RA) signaling in the entire process. C57BL6 male mice were supplemented with 8% (w/v) alcohol in water for 1 or 4 mo. Alcohol intake prevented body weight gain, induced the formation of uncoupling protein 1–positive beige adipocytes in white adipose tissue, and increased thermogenesis in mice, which is associated with decreased serum glucose and triacylglycerol levels. Mechanistically, alcohol intake increased RA levels in serum and adipose tissue, which was associated with increased expression of aldehyde dehydrogenase family 1 subfamily A1 (Aldh1a1). When RA receptor‐α signaling was conditionally blocked in platelet‐derived growth factor receptor‐α‐positive adipose progenitors, the effects of alcohol on beige adipogenesis were largely abolished. Finally, moderate alcohol prevented high‐fat diet‐induced obesity and metabolic dysfunction. In conclusion, moderate alcohol intake induces thermogenic brown/beige adipocyte formation and promotes glucose and lipid oxidation via elevation of RA signaling.—Wang, B., Wang, Z., de Avila, J. M., Zhu, M.‐J., Zhang, F., Gomez, N. A., Zhao, L., Tian, Q., Zhao, J., Maricelli, J., Zhang, H., Rodgers, B. D., Du, M. Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling. FASEB J. 31, 4612–4622 (2017). www.fasebj.org</description><subject>Adipocytes</subject><subject>Adipocytes, Beige - drug effects</subject><subject>Adipocytes, Beige - metabolism</subject><subject>Adipogenesis</subject><subject>Adipose tissue</subject><subject>Adipose Tissue, Brown - drug effects</subject><subject>Adipose Tissue, Brown - metabolism</subject><subject>Adipose Tissue, White - drug effects</subject><subject>Adipose Tissue, White - metabolism</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Alcohols - pharmacology</subject><subject>Aldehyde dehydrogenase</subject><subject>beige adipocyte</subject><subject>Body weight</subject><subject>Body weight gain</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diet, High-Fat</subject><subject>fatty acids</subject><subject>Glucose</subject><subject>High fat diet</subject><subject>Homeostasis</subject><subject>Ion Channels - metabolism</subject><subject>Lipid peroxidation</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mitochondrial Proteins - metabolism</subject><subject>obesity</subject><subject>Obesity - metabolism</subject><subject>Oxidation</subject><subject>Platelet-derived growth factor</subject><subject>Retinoic acid</subject><subject>Rodents</subject><subject>Signal Transduction - drug effects</subject><subject>Signaling</subject><subject>Thermogenesis</subject><subject>Thermogenesis - drug effects</subject><subject>Tretinoin - metabolism</subject><subject>Uncoupling protein 1</subject><issn>0892-6638</issn><issn>1530-6860</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1v1DAQxS0EosvCkSuKxIVLWn8kji0kJKhYKCpCKnC2HGec9eLEWzvZav97XG1b2h44Pc3Mb55m9BB6TfAxwZKf2M0xxaTBmEl-8QQtSM1wyQXHT9ECC0lLzpk4Qi9S2mCMCSb8OTqigjeypmKBLr-HDqKeoNDehHXwhRsn_QeydLOBVExriEPoYXSmaGO4Gk9acH3GO7cNZp8XbYiDnlwYi53TBXjY5WrsiwhZQl7TxnVFcv2ofe6_RM-s9gle3egS_V59_nX6tTz_8eXs9ON5aSoqLkoA0zSWEqg1UN11HGpWV9BWuiJcg2ZCVKLFtqKylYJRiS10xsiGtJZYwdgSfTj4bud2yCMYp6i92kY36LhXQTv1cDK6terDTnGKG9KIbPDuxiCGyxnSpAaXDHivRwhzUkQS3mCZz8jo20foJswx_3tNiYoJRnIMS1QeKBNDShHs3TEEq-swld2of2Fm_s39D-7o2_Qy8P4AXDkP-_-7qdXPT3T17Z79X9fur0s</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Wang, Bo</creator><creator>Wang, Zhixiu</creator><creator>Avila, Jeanene M.</creator><creator>Zhu, Mei‐Jun</creator><creator>Zhang, Faya</creator><creator>Gomez, Noe Alberto</creator><creator>Zhao, Liang</creator><creator>Tian, Qiyu</creator><creator>Zhao, Junxing</creator><creator>Maricelli, Joseph</creator><creator>Zhang, Hui</creator><creator>Rodgers, Buel D.</creator><creator>Du, Min</creator><general>Federation of American Societies for Experimental Biology</general><general>Federation of American Societies for Experimental Biology (FASEB)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201710</creationdate><title>Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling</title><author>Wang, Bo ; Wang, Zhixiu ; Avila, Jeanene M. ; Zhu, Mei‐Jun ; Zhang, Faya ; Gomez, Noe Alberto ; Zhao, Liang ; Tian, Qiyu ; Zhao, Junxing ; Maricelli, Joseph ; Zhang, Hui ; Rodgers, Buel D. ; Du, Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428R-eec77f21e5ae2add6e5354eb4a416aea38848b0f429b983290fedcc971bf1f833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adipocytes</topic><topic>Adipocytes, Beige - drug effects</topic><topic>Adipocytes, Beige - metabolism</topic><topic>Adipogenesis</topic><topic>Adipose tissue</topic><topic>Adipose Tissue, Brown - drug effects</topic><topic>Adipose Tissue, Brown - metabolism</topic><topic>Adipose Tissue, White - drug effects</topic><topic>Adipose Tissue, White - metabolism</topic><topic>Alcohol use</topic><topic>Alcoholic beverages</topic><topic>Alcohols - pharmacology</topic><topic>Aldehyde dehydrogenase</topic><topic>beige adipocyte</topic><topic>Body weight</topic><topic>Body weight gain</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diet, High-Fat</topic><topic>fatty acids</topic><topic>Glucose</topic><topic>High fat diet</topic><topic>Homeostasis</topic><topic>Ion Channels - metabolism</topic><topic>Lipid peroxidation</topic><topic>Metabolic disorders</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Mitochondrial Proteins - metabolism</topic><topic>obesity</topic><topic>Obesity - metabolism</topic><topic>Oxidation</topic><topic>Platelet-derived growth factor</topic><topic>Retinoic acid</topic><topic>Rodents</topic><topic>Signal Transduction - drug effects</topic><topic>Signaling</topic><topic>Thermogenesis</topic><topic>Thermogenesis - drug effects</topic><topic>Tretinoin - metabolism</topic><topic>Uncoupling protein 1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Bo</creatorcontrib><creatorcontrib>Wang, Zhixiu</creatorcontrib><creatorcontrib>Avila, Jeanene M.</creatorcontrib><creatorcontrib>Zhu, Mei‐Jun</creatorcontrib><creatorcontrib>Zhang, Faya</creatorcontrib><creatorcontrib>Gomez, Noe Alberto</creatorcontrib><creatorcontrib>Zhao, Liang</creatorcontrib><creatorcontrib>Tian, Qiyu</creatorcontrib><creatorcontrib>Zhao, Junxing</creatorcontrib><creatorcontrib>Maricelli, Joseph</creatorcontrib><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Rodgers, Buel D.</creatorcontrib><creatorcontrib>Du, Min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The FASEB journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Bo</au><au>Wang, Zhixiu</au><au>Avila, Jeanene M.</au><au>Zhu, Mei‐Jun</au><au>Zhang, Faya</au><au>Gomez, Noe Alberto</au><au>Zhao, Liang</au><au>Tian, Qiyu</au><au>Zhao, Junxing</au><au>Maricelli, Joseph</au><au>Zhang, Hui</au><au>Rodgers, Buel D.</au><au>Du, Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling</atitle><jtitle>The FASEB journal</jtitle><addtitle>FASEB J</addtitle><date>2017-10</date><risdate>2017</risdate><volume>31</volume><issue>10</issue><spage>4612</spage><epage>4622</epage><pages>4612-4622</pages><issn>0892-6638</issn><eissn>1530-6860</eissn><abstract>ABSTRACT
Clinically, low and moderate alcohol intake improves human health with protection against metabolic syndromes, including type 2 diabetes; however, mechanisms that are associated with these effects remain to be elucidated. The aims of this study were to investigate the effects of moderate alcohol intake on thermogenic brown/beige adipocyte formation and glucose and lipid homeostasis, as well as the involvement of retinoic acid (RA) signaling in the entire process. C57BL6 male mice were supplemented with 8% (w/v) alcohol in water for 1 or 4 mo. Alcohol intake prevented body weight gain, induced the formation of uncoupling protein 1–positive beige adipocytes in white adipose tissue, and increased thermogenesis in mice, which is associated with decreased serum glucose and triacylglycerol levels. Mechanistically, alcohol intake increased RA levels in serum and adipose tissue, which was associated with increased expression of aldehyde dehydrogenase family 1 subfamily A1 (Aldh1a1). When RA receptor‐α signaling was conditionally blocked in platelet‐derived growth factor receptor‐α‐positive adipose progenitors, the effects of alcohol on beige adipogenesis were largely abolished. Finally, moderate alcohol prevented high‐fat diet‐induced obesity and metabolic dysfunction. In conclusion, moderate alcohol intake induces thermogenic brown/beige adipocyte formation and promotes glucose and lipid oxidation via elevation of RA signaling.—Wang, B., Wang, Z., de Avila, J. M., Zhu, M.‐J., Zhang, F., Gomez, N. A., Zhao, L., Tian, Q., Zhao, J., Maricelli, J., Zhang, H., Rodgers, B. D., Du, M. Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling. FASEB J. 31, 4612–4622 (2017). www.fasebj.org</abstract><cop>United States</cop><pub>Federation of American Societies for Experimental Biology</pub><pmid>28679528</pmid><doi>10.1096/fj.201700396R</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adipocytes Adipocytes, Beige - drug effects Adipocytes, Beige - metabolism Adipogenesis Adipose tissue Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Adipose Tissue, White - drug effects Adipose Tissue, White - metabolism Alcohol use Alcoholic beverages Alcohols - pharmacology Aldehyde dehydrogenase beige adipocyte Body weight Body weight gain Diabetes mellitus Diabetes Mellitus, Type 2 - metabolism Diet, High-Fat fatty acids Glucose High fat diet Homeostasis Ion Channels - metabolism Lipid peroxidation Metabolic disorders Metabolism Mice Mitochondrial Proteins - metabolism obesity Obesity - metabolism Oxidation Platelet-derived growth factor Retinoic acid Rodents Signal Transduction - drug effects Signaling Thermogenesis Thermogenesis - drug effects Tretinoin - metabolism Uncoupling protein 1 |
| title | Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling |
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