Evaluation of N-Succinimidyl S-Acetylthioacetate Ligand for Radiolabeling of Humanized Antibodies with 188Rhenium

Radioimmunotherapy offers an effective way to direct ionizing radiation to cancer cells through attachment of radionuclides to antibodies while limiting negative effects of off-target irradiation. This, however, requires effective facile methods for attachment of therapeutic radionuclides onto antib...

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Veröffentlicht in:	Cancer biotherapy & radiopharmaceuticals 2018-10, Vol.33 (8), p.349-355
Hauptverfasser:	Allen, Kevin JH, Rubin Jiao, Malo, Mackenzie E, Dadachova, Ekaterina
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cancer therapies Chelation Drug dosages Half-life High performance liquid chromatography Immunoglobulin G Immunoglobulins Ionizing radiation Irradiation Laboratories Ligands Liquid chromatography Medical research Melanin Melanoma Metastasis Original Pharmacy Prostate cancer Radioactive half-life Radioisotopes Rhenium Single photon emission computed tomography Sodium Thin layer chromatography
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