Improvement of Chronic Idiopathic Urticaria With Levothyroxine: A Case Report and Review of Literature
There is an increased association between chronic urticaria (CU) and thyroid autoantibodies. We presented a case of a patient suffering from CU and newly diagnosed Hashimoto's thyroiditis in which levothyroxine therapy completely resolved the symptoms of urticaria. A 58-year-old female with a p...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2018-08, Vol.10 (8), p.e3209 |
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| creator | Shahbaz, Amir Senapathi, Sri Harshavardhan Aziz, Kashif Umair, Muhammad Khalid, Amna Sachmechi, Issac |
| description | There is an increased association between chronic urticaria (CU) and thyroid autoantibodies. We presented a case of a patient suffering from CU and newly diagnosed Hashimoto's thyroiditis in which levothyroxine therapy completely resolved the symptoms of urticaria. A 58-year-old female with a past medical history of recurrent urticaria presented with complaints of fatigue and weight gain. Laboratory investigations showed a high thyroid stimulating hormone (TSH) level and a low free thyroxine (T4) level. She had elevated levels of antithyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies (anti-TG). She was diagnosed as a case of Hashimoto's thyroiditis and started on levothyroxine therapy. She noticed that her uncontrolled recurrent urticaria started to get better and after a few months of therapy, she stopped taking her topical ointments and antihistamines. The reason for the association between positive serological tests for thyroid autoimmunity and CU is unclear. The resolution of chronic urticaria with levothyroxine in our patient with Hashimoto's thyroiditis suggests a common underlying mechanism between the two pathologies. |
| doi_str_mv | 10.7759/cureus.3209 |
| format | Article |
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We presented a case of a patient suffering from CU and newly diagnosed Hashimoto's thyroiditis in which levothyroxine therapy completely resolved the symptoms of urticaria. A 58-year-old female with a past medical history of recurrent urticaria presented with complaints of fatigue and weight gain. Laboratory investigations showed a high thyroid stimulating hormone (TSH) level and a low free thyroxine (T4) level. She had elevated levels of antithyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies (anti-TG). She was diagnosed as a case of Hashimoto's thyroiditis and started on levothyroxine therapy. She noticed that her uncontrolled recurrent urticaria started to get better and after a few months of therapy, she stopped taking her topical ointments and antihistamines. The reason for the association between positive serological tests for thyroid autoimmunity and CU is unclear. The resolution of chronic urticaria with levothyroxine in our patient with Hashimoto's thyroiditis suggests a common underlying mechanism between the two pathologies.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.3209</identifier><identifier>PMID: 30405985</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Case reports ; Cytokines ; Dermatitis ; Endocrinology/Diabetes/Metabolism ; Family medical history ; Hospitals ; Hypothyroidism ; Immunoglobulins ; Internal Medicine ; Medicine ; Patients ; Thyroid gland ; Urticaria</subject><ispartof>Curēus (Palo Alto, CA), 2018-08, Vol.10 (8), p.e3209</ispartof><rights>Copyright © 2018, Shahbaz et al. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). 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We presented a case of a patient suffering from CU and newly diagnosed Hashimoto's thyroiditis in which levothyroxine therapy completely resolved the symptoms of urticaria. A 58-year-old female with a past medical history of recurrent urticaria presented with complaints of fatigue and weight gain. Laboratory investigations showed a high thyroid stimulating hormone (TSH) level and a low free thyroxine (T4) level. She had elevated levels of antithyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies (anti-TG). She was diagnosed as a case of Hashimoto's thyroiditis and started on levothyroxine therapy. She noticed that her uncontrolled recurrent urticaria started to get better and after a few months of therapy, she stopped taking her topical ointments and antihistamines. The reason for the association between positive serological tests for thyroid autoimmunity and CU is unclear. 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| subjects | Case reports Cytokines Dermatitis Endocrinology/Diabetes/Metabolism Family medical history Hospitals Hypothyroidism Immunoglobulins Internal Medicine Medicine Patients Thyroid gland Urticaria |
| title | Improvement of Chronic Idiopathic Urticaria With Levothyroxine: A Case Report and Review of Literature |
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