Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders

Functional gastrointestinal disorders (FGIDs) and IBDs are two of the most prevalent disorders of the GI tract and consume a significant proportion of healthcare resources. Recent studies have shown that membrane-bound guanylate cyclase-C (GC-C) receptors lining the GI tract may serve as novel thera...

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Veröffentlicht in:	Gut 2018-08, Vol.67 (8), p.1543-1552
Hauptverfasser:	Waldman, Scott A, Camilleri, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory agents Clinical trials Colon Constipation Cyclic GMP Gastroenterology Gastrointestinal diseases Gastrointestinal tract Gene expression Guanylate cyclase Homeostasis Hormones Inflammation Intestine Irritable bowel syndrome Ligands Paracrine signalling pH effects Physiology Recent Advances in Clinical Practice Receptor mechanisms Small intestine Therapeutic applications Uroguanylin
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