$Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II study$

Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II study

ObjectiveRegorafenib demonstrated efficacy in patients with metastatic colorectal cancer (mCRC). Lack of predictive biomarkers, potential toxicities and cost-effectiveness concerns highlight the unmet need for better patient selection.DesignPatients with RAS mutant mCRC with biopsiable metastases we...

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Veröffentlicht in:	Gut 2018-08, Vol.67 (8), p.1484-1492
Hauptverfasser:	Khan, Khurum, Rata, Mihaela, Cunningham, David, Koh, Dow-Mu, Tunariu, Nina, Hahne, Jens C, Vlachogiannis, George, Hedayat, Somaieh, Marchetti, Silvia, Lampis, Andrea, Damavandi, Mahnaz Darvish, Lote, Hazel, Rana, Isma, Williams, Anja, Eccles, Suzanne A, Fontana, Elisa, Collins, David, Eltahir, Zakaria, Rao, Sheela, Watkins, David, Starling, Naureen, Thomas, Jan, Kalaitzaki, Eleftheria, Fotiadis, Nicos, Begum, Ruwaida, Bali, Maria, Rugge, Massimo, Temple, Eleanor, Fassan, Matteo, Chau, Ian, Braconi, Chiara, Valeri, Nicola
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Angiogenesis Apoptosis Biomarkers Biomarkers - blood Cancer therapies Clinical medicine Clinical trials Colon Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - blood Colorectal Neoplasms - diagnostic imaging Colorectal Neoplasms - drug therapy Computed tomography Decay Deoxyribonucleic acid Disease control DNA Female Humans Immunohistochemistry Inhibitor drugs Kaplan-Meier Estimate Magnetic Resonance Imaging Male Medical imaging Medical prognosis Metastases Metastasis Middle Aged NMR Nuclear magnetic resonance Patients Phenylurea Compounds - therapeutic use Prospective Studies Pyridines - therapeutic use Studies Targeted cancer therapy Treatment Outcome Tumors Vascular endothelial growth factor
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