Inhibitory effects of cannabidiol on voltage-dependent sodium currents

Cannabis sativa contains many related compounds known as phytocannabinoids. The main psychoactive and nonpsychoactive compounds are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), respectively. Much of the evidence for clinical efficacy of CBD-mediated antiepileptic effects has been from case r...

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Veröffentlicht in:	The Journal of biological chemistry 2018-10, Vol.293 (43), p.16546-16558
Hauptverfasser:	Ghovanloo, Mohammad-Reza, Shuart, Noah Gregory, Mezeyova, Janette, Dean, Richard A., Ruben, Peter C., Goodchild, Samuel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	cannabidiol Cannabidiol - pharmacology cannabinoid central nervous system (CNS) electrophysiology epilepsy Gene Expression Regulation - drug effects HEK293 Cells Humans Kv2.1 Molecular Biophysics NAV1.1 Voltage-Gated Sodium Channel - chemistry NAV1.1 Voltage-Gated Sodium Channel - genetics NAV1.1 Voltage-Gated Sodium Channel - metabolism NAV1.6 Voltage-Gated Sodium Channel - chemistry NAV1.6 Voltage-Gated Sodium Channel - genetics NAV1.6 Voltage-Gated Sodium Channel - metabolism neuron Neurons - drug effects Neurons - metabolism Neurons - pathology phytocannabinoid Sodium - metabolism sodium channel voltage-gated sodium channel Voltage-Gated Sodium Channel beta-1 Subunit - chemistry Voltage-Gated Sodium Channel beta-1 Subunit - genetics Voltage-Gated Sodium Channel beta-1 Subunit - metabolism
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