Discrimination exposure and DNA methylation of stress-related genes in Latina mothers

•DNA methylation of genes implicated in stress-related disorders predicts discrimination.•Discrimination is inversely associated with NR3C1 and BDNF methylation over time.•Discrimination is inversely associated with FKBP5 methylation at T1 but not at T2.•BDNF data support the hypothesis of discrimin...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Psychoneuroendocrinology 2018-12, Vol.98, p.131-138
Hauptverfasser: Santos, Hudson P., Nephew, Benjamin C., Bhattacharya, Arjun, Tan, Xianming, Smith, Laura, Alyamani, Reema Abdulrahman S., Martin, Elizabeth M., Perreira, Krista, Fry, Rebecca C., Murgatroyd, Christopher
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 138
container_issue
container_start_page 131
container_title Psychoneuroendocrinology
container_volume 98
creator Santos, Hudson P.
Nephew, Benjamin C.
Bhattacharya, Arjun
Tan, Xianming
Smith, Laura
Alyamani, Reema Abdulrahman S.
Martin, Elizabeth M.
Perreira, Krista
Fry, Rebecca C.
Murgatroyd, Christopher
description •DNA methylation of genes implicated in stress-related disorders predicts discrimination.•Discrimination is inversely associated with NR3C1 and BDNF methylation over time.•Discrimination is inversely associated with FKBP5 methylation at T1 but not at T2.•BDNF data support the hypothesis of discrimination associated neuroplasticity. Latina mothers, who have the highest fertility rate among all ethnic groups in the US, are often exposed to discrimination. The epigenetic changes related to this discrimination are largely unknown. This study is the first to explore the relationship between discrimination and DNA methylation of stress regulatory genes in Latinas. Our sample was Latina women (n = 147) with a mean age of 27.6 years who were assessed at 24–32 weeks’ gestation (T1) and 4–6 weeks postpartum (T2) and reside in the U.S. Blood was collected at T1, and the Everyday Discrimination Scale (EDS) was administered at T1 and T2. DNA Methylation at candidate gene regions was determined by bisulphite pyrosequencing. Associations between EDS and DNA methylation were assessed via zero-inflated Poisson models, adjusting for covariates and multiple-test comparisons. Discrimination was negatively associated with methylation at CpG sites within the glucocorticoid receptor (NR3C1) and brain-derived neurotrophic factor (BDNF) genes that were consistent over time. In addition, discrimination was negatively associated with methylation of a CpG in the glucocorticoid binding protein (FKBP5) at T1 but not at T2. This study underscores associations between discrimination and epigenetic markers of DNA methylation in Latinas that warrant further investigation to better understand the biological pathways and psychopathological effects of discrimination on Latina mothers and their families.
doi_str_mv 10.1016/j.psyneuen.2018.08.014
format Article
fullrecord <record><control><sourceid>elsevier_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6204298</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S030645301830386X</els_id><sourcerecordid>S030645301830386X</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-9bbc317a5bddbbccd0b678323536b5dfb09473e434cbf4a0ceda18aeeab706db3</originalsourceid><addsrcrecordid>eNqFUNtKAzEQDaJorf6C5Ae2TjZpdvsiivUGRV_sc8hltk1psyXZFvv3RmpFn4SBGWbOOcM5hFwxGDBg8noxWKddwA2GQQmsHkAuJo5Ij9UVLziXcEx6wEEWYsjhjJyntAAAWcvylJzxjBVVDT0yHftko1_5oDvfBoof6zZtIlIdHB2_3tEVdvPdcn9sG5q6iCkVEfMKHZ1hwER9oJOMCJqu2m6OMV2Qk0YvE15-9z6ZPj683z8Xk7enl_u7SWFFxbpiZIzlrNJD41werQMjq5qXfMilGbrGwEhUHAUX1jRCg0WnWa0RtalAOsP75Gavu96YFTqLoYt6qdbZkI471Wqv_l6Cn6tZu1WyBFGO6iwg9wI2tilFbH64DNRX0GqhDkGrr6AV5GIiE69-f_6hHZLNgNs9ALP_rceokvUYsgUf0XbKtf6_H59gLpdA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Discrimination exposure and DNA methylation of stress-related genes in Latina mothers</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Santos, Hudson P. ; Nephew, Benjamin C. ; Bhattacharya, Arjun ; Tan, Xianming ; Smith, Laura ; Alyamani, Reema Abdulrahman S. ; Martin, Elizabeth M. ; Perreira, Krista ; Fry, Rebecca C. ; Murgatroyd, Christopher</creator><creatorcontrib>Santos, Hudson P. ; Nephew, Benjamin C. ; Bhattacharya, Arjun ; Tan, Xianming ; Smith, Laura ; Alyamani, Reema Abdulrahman S. ; Martin, Elizabeth M. ; Perreira, Krista ; Fry, Rebecca C. ; Murgatroyd, Christopher</creatorcontrib><description>•DNA methylation of genes implicated in stress-related disorders predicts discrimination.•Discrimination is inversely associated with NR3C1 and BDNF methylation over time.•Discrimination is inversely associated with FKBP5 methylation at T1 but not at T2.•BDNF data support the hypothesis of discrimination associated neuroplasticity. Latina mothers, who have the highest fertility rate among all ethnic groups in the US, are often exposed to discrimination. The epigenetic changes related to this discrimination are largely unknown. This study is the first to explore the relationship between discrimination and DNA methylation of stress regulatory genes in Latinas. Our sample was Latina women (n = 147) with a mean age of 27.6 years who were assessed at 24–32 weeks’ gestation (T1) and 4–6 weeks postpartum (T2) and reside in the U.S. Blood was collected at T1, and the Everyday Discrimination Scale (EDS) was administered at T1 and T2. DNA Methylation at candidate gene regions was determined by bisulphite pyrosequencing. Associations between EDS and DNA methylation were assessed via zero-inflated Poisson models, adjusting for covariates and multiple-test comparisons. Discrimination was negatively associated with methylation at CpG sites within the glucocorticoid receptor (NR3C1) and brain-derived neurotrophic factor (BDNF) genes that were consistent over time. In addition, discrimination was negatively associated with methylation of a CpG in the glucocorticoid binding protein (FKBP5) at T1 but not at T2. This study underscores associations between discrimination and epigenetic markers of DNA methylation in Latinas that warrant further investigation to better understand the biological pathways and psychopathological effects of discrimination on Latina mothers and their families.</description><identifier>ISSN: 0306-4530</identifier><identifier>EISSN: 1873-3360</identifier><identifier>DOI: 10.1016/j.psyneuen.2018.08.014</identifier><identifier>PMID: 30144780</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Brain-Derived Neurotrophic Factor - genetics ; Brain-Derived Neurotrophic Factor - metabolism ; CpG Islands - genetics ; Discrimination ; DNA methylation ; DNA Methylation - genetics ; Epigenesis, Genetic - genetics ; Epigenetics ; Female ; Hispanic or Latino - genetics ; Hispanic or Latino - psychology ; Hispanic/Latina ; Humans ; Hydrocortisone ; Mothers ; Neuronal Plasticity ; Pregnancy ; Promoter Regions, Genetic - genetics ; Receptors, Glucocorticoid - genetics ; Receptors, Glucocorticoid - metabolism ; Social Discrimination - psychology ; Stress ; Stress, Psychological - genetics ; Stress, Psychological - metabolism ; Tacrolimus Binding Proteins - genetics ; Tacrolimus Binding Proteins - metabolism ; Women’s health</subject><ispartof>Psychoneuroendocrinology, 2018-12, Vol.98, p.131-138</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-9bbc317a5bddbbccd0b678323536b5dfb09473e434cbf4a0ceda18aeeab706db3</citedby><cites>FETCH-LOGICAL-c471t-9bbc317a5bddbbccd0b678323536b5dfb09473e434cbf4a0ceda18aeeab706db3</cites><orcidid>0000-0002-4567-4071 ; 0000-0002-4040-366X ; 0000-0002-6885-7794 ; 0000-0001-8428-7034 ; 0000-0002-5478-2269</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.psyneuen.2018.08.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30144780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santos, Hudson P.</creatorcontrib><creatorcontrib>Nephew, Benjamin C.</creatorcontrib><creatorcontrib>Bhattacharya, Arjun</creatorcontrib><creatorcontrib>Tan, Xianming</creatorcontrib><creatorcontrib>Smith, Laura</creatorcontrib><creatorcontrib>Alyamani, Reema Abdulrahman S.</creatorcontrib><creatorcontrib>Martin, Elizabeth M.</creatorcontrib><creatorcontrib>Perreira, Krista</creatorcontrib><creatorcontrib>Fry, Rebecca C.</creatorcontrib><creatorcontrib>Murgatroyd, Christopher</creatorcontrib><title>Discrimination exposure and DNA methylation of stress-related genes in Latina mothers</title><title>Psychoneuroendocrinology</title><addtitle>Psychoneuroendocrinology</addtitle><description>•DNA methylation of genes implicated in stress-related disorders predicts discrimination.•Discrimination is inversely associated with NR3C1 and BDNF methylation over time.•Discrimination is inversely associated with FKBP5 methylation at T1 but not at T2.•BDNF data support the hypothesis of discrimination associated neuroplasticity. Latina mothers, who have the highest fertility rate among all ethnic groups in the US, are often exposed to discrimination. The epigenetic changes related to this discrimination are largely unknown. This study is the first to explore the relationship between discrimination and DNA methylation of stress regulatory genes in Latinas. Our sample was Latina women (n = 147) with a mean age of 27.6 years who were assessed at 24–32 weeks’ gestation (T1) and 4–6 weeks postpartum (T2) and reside in the U.S. Blood was collected at T1, and the Everyday Discrimination Scale (EDS) was administered at T1 and T2. DNA Methylation at candidate gene regions was determined by bisulphite pyrosequencing. Associations between EDS and DNA methylation were assessed via zero-inflated Poisson models, adjusting for covariates and multiple-test comparisons. Discrimination was negatively associated with methylation at CpG sites within the glucocorticoid receptor (NR3C1) and brain-derived neurotrophic factor (BDNF) genes that were consistent over time. In addition, discrimination was negatively associated with methylation of a CpG in the glucocorticoid binding protein (FKBP5) at T1 but not at T2. This study underscores associations between discrimination and epigenetic markers of DNA methylation in Latinas that warrant further investigation to better understand the biological pathways and psychopathological effects of discrimination on Latina mothers and their families.</description><subject>Adult</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>CpG Islands - genetics</subject><subject>Discrimination</subject><subject>DNA methylation</subject><subject>DNA Methylation - genetics</subject><subject>Epigenesis, Genetic - genetics</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Hispanic or Latino - genetics</subject><subject>Hispanic or Latino - psychology</subject><subject>Hispanic/Latina</subject><subject>Humans</subject><subject>Hydrocortisone</subject><subject>Mothers</subject><subject>Neuronal Plasticity</subject><subject>Pregnancy</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Receptors, Glucocorticoid - genetics</subject><subject>Receptors, Glucocorticoid - metabolism</subject><subject>Social Discrimination - psychology</subject><subject>Stress</subject><subject>Stress, Psychological - genetics</subject><subject>Stress, Psychological - metabolism</subject><subject>Tacrolimus Binding Proteins - genetics</subject><subject>Tacrolimus Binding Proteins - metabolism</subject><subject>Women’s health</subject><issn>0306-4530</issn><issn>1873-3360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUNtKAzEQDaJorf6C5Ae2TjZpdvsiivUGRV_sc8hltk1psyXZFvv3RmpFn4SBGWbOOcM5hFwxGDBg8noxWKddwA2GQQmsHkAuJo5Ij9UVLziXcEx6wEEWYsjhjJyntAAAWcvylJzxjBVVDT0yHftko1_5oDvfBoof6zZtIlIdHB2_3tEVdvPdcn9sG5q6iCkVEfMKHZ1hwER9oJOMCJqu2m6OMV2Qk0YvE15-9z6ZPj683z8Xk7enl_u7SWFFxbpiZIzlrNJD41werQMjq5qXfMilGbrGwEhUHAUX1jRCg0WnWa0RtalAOsP75Gavu96YFTqLoYt6qdbZkI471Wqv_l6Cn6tZu1WyBFGO6iwg9wI2tilFbH64DNRX0GqhDkGrr6AV5GIiE69-f_6hHZLNgNs9ALP_rceokvUYsgUf0XbKtf6_H59gLpdA</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Santos, Hudson P.</creator><creator>Nephew, Benjamin C.</creator><creator>Bhattacharya, Arjun</creator><creator>Tan, Xianming</creator><creator>Smith, Laura</creator><creator>Alyamani, Reema Abdulrahman S.</creator><creator>Martin, Elizabeth M.</creator><creator>Perreira, Krista</creator><creator>Fry, Rebecca C.</creator><creator>Murgatroyd, Christopher</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4567-4071</orcidid><orcidid>https://orcid.org/0000-0002-4040-366X</orcidid><orcidid>https://orcid.org/0000-0002-6885-7794</orcidid><orcidid>https://orcid.org/0000-0001-8428-7034</orcidid><orcidid>https://orcid.org/0000-0002-5478-2269</orcidid></search><sort><creationdate>20181201</creationdate><title>Discrimination exposure and DNA methylation of stress-related genes in Latina mothers</title><author>Santos, Hudson P. ; Nephew, Benjamin C. ; Bhattacharya, Arjun ; Tan, Xianming ; Smith, Laura ; Alyamani, Reema Abdulrahman S. ; Martin, Elizabeth M. ; Perreira, Krista ; Fry, Rebecca C. ; Murgatroyd, Christopher</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-9bbc317a5bddbbccd0b678323536b5dfb09473e434cbf4a0ceda18aeeab706db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>CpG Islands - genetics</topic><topic>Discrimination</topic><topic>DNA methylation</topic><topic>DNA Methylation - genetics</topic><topic>Epigenesis, Genetic - genetics</topic><topic>Epigenetics</topic><topic>Female</topic><topic>Hispanic or Latino - genetics</topic><topic>Hispanic or Latino - psychology</topic><topic>Hispanic/Latina</topic><topic>Humans</topic><topic>Hydrocortisone</topic><topic>Mothers</topic><topic>Neuronal Plasticity</topic><topic>Pregnancy</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Receptors, Glucocorticoid - genetics</topic><topic>Receptors, Glucocorticoid - metabolism</topic><topic>Social Discrimination - psychology</topic><topic>Stress</topic><topic>Stress, Psychological - genetics</topic><topic>Stress, Psychological - metabolism</topic><topic>Tacrolimus Binding Proteins - genetics</topic><topic>Tacrolimus Binding Proteins - metabolism</topic><topic>Women’s health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santos, Hudson P.</creatorcontrib><creatorcontrib>Nephew, Benjamin C.</creatorcontrib><creatorcontrib>Bhattacharya, Arjun</creatorcontrib><creatorcontrib>Tan, Xianming</creatorcontrib><creatorcontrib>Smith, Laura</creatorcontrib><creatorcontrib>Alyamani, Reema Abdulrahman S.</creatorcontrib><creatorcontrib>Martin, Elizabeth M.</creatorcontrib><creatorcontrib>Perreira, Krista</creatorcontrib><creatorcontrib>Fry, Rebecca C.</creatorcontrib><creatorcontrib>Murgatroyd, Christopher</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psychoneuroendocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santos, Hudson P.</au><au>Nephew, Benjamin C.</au><au>Bhattacharya, Arjun</au><au>Tan, Xianming</au><au>Smith, Laura</au><au>Alyamani, Reema Abdulrahman S.</au><au>Martin, Elizabeth M.</au><au>Perreira, Krista</au><au>Fry, Rebecca C.</au><au>Murgatroyd, Christopher</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discrimination exposure and DNA methylation of stress-related genes in Latina mothers</atitle><jtitle>Psychoneuroendocrinology</jtitle><addtitle>Psychoneuroendocrinology</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>98</volume><spage>131</spage><epage>138</epage><pages>131-138</pages><issn>0306-4530</issn><eissn>1873-3360</eissn><abstract>•DNA methylation of genes implicated in stress-related disorders predicts discrimination.•Discrimination is inversely associated with NR3C1 and BDNF methylation over time.•Discrimination is inversely associated with FKBP5 methylation at T1 but not at T2.•BDNF data support the hypothesis of discrimination associated neuroplasticity. Latina mothers, who have the highest fertility rate among all ethnic groups in the US, are often exposed to discrimination. The epigenetic changes related to this discrimination are largely unknown. This study is the first to explore the relationship between discrimination and DNA methylation of stress regulatory genes in Latinas. Our sample was Latina women (n = 147) with a mean age of 27.6 years who were assessed at 24–32 weeks’ gestation (T1) and 4–6 weeks postpartum (T2) and reside in the U.S. Blood was collected at T1, and the Everyday Discrimination Scale (EDS) was administered at T1 and T2. DNA Methylation at candidate gene regions was determined by bisulphite pyrosequencing. Associations between EDS and DNA methylation were assessed via zero-inflated Poisson models, adjusting for covariates and multiple-test comparisons. Discrimination was negatively associated with methylation at CpG sites within the glucocorticoid receptor (NR3C1) and brain-derived neurotrophic factor (BDNF) genes that were consistent over time. In addition, discrimination was negatively associated with methylation of a CpG in the glucocorticoid binding protein (FKBP5) at T1 but not at T2. This study underscores associations between discrimination and epigenetic markers of DNA methylation in Latinas that warrant further investigation to better understand the biological pathways and psychopathological effects of discrimination on Latina mothers and their families.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30144780</pmid><doi>10.1016/j.psyneuen.2018.08.014</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4567-4071</orcidid><orcidid>https://orcid.org/0000-0002-4040-366X</orcidid><orcidid>https://orcid.org/0000-0002-6885-7794</orcidid><orcidid>https://orcid.org/0000-0001-8428-7034</orcidid><orcidid>https://orcid.org/0000-0002-5478-2269</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0306-4530
ispartof Psychoneuroendocrinology, 2018-12, Vol.98, p.131-138
issn 0306-4530
1873-3360
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6204298
source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Adult
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
CpG Islands - genetics
Discrimination
DNA methylation
DNA Methylation - genetics
Epigenesis, Genetic - genetics
Epigenetics
Female
Hispanic or Latino - genetics
Hispanic or Latino - psychology
Hispanic/Latina
Humans
Hydrocortisone
Mothers
Neuronal Plasticity
Pregnancy
Promoter Regions, Genetic - genetics
Receptors, Glucocorticoid - genetics
Receptors, Glucocorticoid - metabolism
Social Discrimination - psychology
Stress
Stress, Psychological - genetics
Stress, Psychological - metabolism
Tacrolimus Binding Proteins - genetics
Tacrolimus Binding Proteins - metabolism
Women’s health
title Discrimination exposure and DNA methylation of stress-related genes in Latina mothers
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T15%3A23%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Discrimination%20exposure%20and%20DNA%20methylation%20of%20stress-related%20genes%20in%20Latina%20mothers&rft.jtitle=Psychoneuroendocrinology&rft.au=Santos,%20Hudson%20P.&rft.date=2018-12-01&rft.volume=98&rft.spage=131&rft.epage=138&rft.pages=131-138&rft.issn=0306-4530&rft.eissn=1873-3360&rft_id=info:doi/10.1016/j.psyneuen.2018.08.014&rft_dat=%3Celsevier_pubme%3ES030645301830386X%3C/elsevier_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/30144780&rft_els_id=S030645301830386X&rfr_iscdi=true