Allostatic load and disordered white matter microstructure in overweight adults
Overweight and stress are both related to brain structural abnormalities. The allostatic load model states that frequent disruption of homeostasis is inherently linked to oxidative stress and inflammatory responses that in turn can damage the brain. However, the effects of the allostatic load on the...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2018-10, Vol.8 (1), p.15898-12, Article 15898 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 12 |
|---|---|
| container_issue | 1 |
| container_start_page | 15898 |
| container_title | Scientific reports |
| container_volume | 8 |
| creator | Ottino-González, J. Jurado, M. A. García-García, I. Segura, B. Marqués-Iturria, I. Sender-Palacios, M. J. Tor, E. Prats-Soteras, X. Caldú, X. Junqué, C. Pasternak, O. Garolera, M. |
| description | Overweight and stress are both related to brain structural abnormalities. The allostatic load model states that frequent disruption of homeostasis is inherently linked to oxidative stress and inflammatory responses that in turn can damage the brain. However, the effects of the allostatic load on the central nervous system remain largely unknown. The current study aimed to assess the relationship between the allostatic load and the composition of whole-brain white matter tracts in overweight subjects. Additionally, we have also tested for grey matter changes regarding allostatic load increase. Thirty-one overweight-to-obese adults and 21 lean controls participated in the study. Our results showed that overweight participants presented higher allostatic load indexes. Such increases correlated with lower fractional anisotropy in the inferior fronto-occipital fasciculi and the right anterior corona radiata, as well as with grey matter reductions in the left precentral gyrus, the left lateral occipital gyrus, and the right pars opercularis. These results suggest that an otherwise healthy overweight status is linked to long-term biological changes potentially harmful to the brain. |
| doi_str_mv | 10.1038/s41598-018-34219-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6203765</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2126916270</sourcerecordid><originalsourceid>FETCH-LOGICAL-c631t-b6f21f89b3707362dda8bc7d97957da8907250d08430692110c647994e7c891a3</originalsourceid><addsrcrecordid>eNp9UV1rFDEUHUSxpfYP-CABX3wZTW4mXy9CKX5BoS_6HLLJ3d2UmUlNMi3992a761p9MBBywz3n3I_Tda8Zfc8o1x_KwITRPWW65wMw0-tn3SnQQfTAAZ4_iU-681JuaDsCzMDMy-6EUy4VY_S0u74Yx1Sqq9GTMblA3BxIiCXlgBkDud_GimRytWImU_S5gfPi65KRxJmkO8z3GDfbSlxYxlpedS_Wbix4fnjPuh-fP32__NpfXX_5dnlx1XvJWe1Xcg1src2KK6q4hBCcXnkVjDJCtdhQBYIGqgdOpYHWqpeDMmZA5bVhjp91H_e6t8tqwuBxrtmN9jbHyeUHm1y0f2fmuLWbdGclUK6kaAJsL-DL4m1Gj9m7-kg8fnYXWieWCwYwNM67Q9Gcfi5Yqp1i8TiObsa0FAsMpGESFG3Qt_9Ab9KS57aSHUpIQbkwDQWHJtpeS8b1cQBG7c5mu7fZNpvto81WN9Kbp6MfKb9NbQC-B5SWmjeY_9T-j-wveAmyYg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2125650359</pqid></control><display><type>article</type><title>Allostatic load and disordered white matter microstructure in overweight adults</title><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>Recercat</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><source>Springer Nature OA Free Journals</source><creator>Ottino-González, J. ; Jurado, M. A. ; García-García, I. ; Segura, B. ; Marqués-Iturria, I. ; Sender-Palacios, M. J. ; Tor, E. ; Prats-Soteras, X. ; Caldú, X. ; Junqué, C. ; Pasternak, O. ; Garolera, M.</creator><creatorcontrib>Ottino-González, J. ; Jurado, M. A. ; García-García, I. ; Segura, B. ; Marqués-Iturria, I. ; Sender-Palacios, M. J. ; Tor, E. ; Prats-Soteras, X. ; Caldú, X. ; Junqué, C. ; Pasternak, O. ; Garolera, M.</creatorcontrib><description>Overweight and stress are both related to brain structural abnormalities. The allostatic load model states that frequent disruption of homeostasis is inherently linked to oxidative stress and inflammatory responses that in turn can damage the brain. However, the effects of the allostatic load on the central nervous system remain largely unknown. The current study aimed to assess the relationship between the allostatic load and the composition of whole-brain white matter tracts in overweight subjects. Additionally, we have also tested for grey matter changes regarding allostatic load increase. Thirty-one overweight-to-obese adults and 21 lean controls participated in the study. Our results showed that overweight participants presented higher allostatic load indexes. Such increases correlated with lower fractional anisotropy in the inferior fronto-occipital fasciculi and the right anterior corona radiata, as well as with grey matter reductions in the left precentral gyrus, the left lateral occipital gyrus, and the right pars opercularis. These results suggest that an otherwise healthy overweight status is linked to long-term biological changes potentially harmful to the brain.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-34219-8</identifier><identifier>PMID: 30367110</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/57 ; 631/378/1488/393 ; 631/378/1831 ; Anisotropy ; Assaigs clínics ; Biomarkers ; Body mass index ; Body weight ; Brain ; Brain injury ; Central nervous system ; Cervell ; Clinical trials ; Cytokines ; Estrès (Fisiologia) ; Homeostasis ; Hormones ; Humanities and Social Sciences ; Inflammation ; Metabolism ; multidisciplinary ; Obesitat ; Obesity ; Overweight ; Oxidative stress ; Physiology ; Precentral gyrus ; Science ; Science (multidisciplinary) ; Sistema nerviós central ; Stress (Physiology) ; Substantia alba ; Substantia grisea ; Thermogenesis ; Weight control</subject><ispartof>Scientific reports, 2018-10, Vol.8 (1), p.15898-12, Article 15898</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>cc-by (c) Ottino González, Jonatan et al., 2018 info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by/3.0/es">http://creativecommons.org/licenses/by/3.0/es</a></rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c631t-b6f21f89b3707362dda8bc7d97957da8907250d08430692110c647994e7c891a3</citedby><cites>FETCH-LOGICAL-c631t-b6f21f89b3707362dda8bc7d97957da8907250d08430692110c647994e7c891a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203765/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203765/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,26951,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30367110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ottino-González, J.</creatorcontrib><creatorcontrib>Jurado, M. A.</creatorcontrib><creatorcontrib>García-García, I.</creatorcontrib><creatorcontrib>Segura, B.</creatorcontrib><creatorcontrib>Marqués-Iturria, I.</creatorcontrib><creatorcontrib>Sender-Palacios, M. J.</creatorcontrib><creatorcontrib>Tor, E.</creatorcontrib><creatorcontrib>Prats-Soteras, X.</creatorcontrib><creatorcontrib>Caldú, X.</creatorcontrib><creatorcontrib>Junqué, C.</creatorcontrib><creatorcontrib>Pasternak, O.</creatorcontrib><creatorcontrib>Garolera, M.</creatorcontrib><title>Allostatic load and disordered white matter microstructure in overweight adults</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Overweight and stress are both related to brain structural abnormalities. The allostatic load model states that frequent disruption of homeostasis is inherently linked to oxidative stress and inflammatory responses that in turn can damage the brain. However, the effects of the allostatic load on the central nervous system remain largely unknown. The current study aimed to assess the relationship between the allostatic load and the composition of whole-brain white matter tracts in overweight subjects. Additionally, we have also tested for grey matter changes regarding allostatic load increase. Thirty-one overweight-to-obese adults and 21 lean controls participated in the study. Our results showed that overweight participants presented higher allostatic load indexes. Such increases correlated with lower fractional anisotropy in the inferior fronto-occipital fasciculi and the right anterior corona radiata, as well as with grey matter reductions in the left precentral gyrus, the left lateral occipital gyrus, and the right pars opercularis. These results suggest that an otherwise healthy overweight status is linked to long-term biological changes potentially harmful to the brain.</description><subject>59/57</subject><subject>631/378/1488/393</subject><subject>631/378/1831</subject><subject>Anisotropy</subject><subject>Assaigs clínics</subject><subject>Biomarkers</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Brain</subject><subject>Brain injury</subject><subject>Central nervous system</subject><subject>Cervell</subject><subject>Clinical trials</subject><subject>Cytokines</subject><subject>Estrès (Fisiologia)</subject><subject>Homeostasis</subject><subject>Hormones</subject><subject>Humanities and Social Sciences</subject><subject>Inflammation</subject><subject>Metabolism</subject><subject>multidisciplinary</subject><subject>Obesitat</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Oxidative stress</subject><subject>Physiology</subject><subject>Precentral gyrus</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sistema nerviós central</subject><subject>Stress (Physiology)</subject><subject>Substantia alba</subject><subject>Substantia grisea</subject><subject>Thermogenesis</subject><subject>Weight control</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><sourceid>XX2</sourceid><recordid>eNp9UV1rFDEUHUSxpfYP-CABX3wZTW4mXy9CKX5BoS_6HLLJ3d2UmUlNMi3992a761p9MBBywz3n3I_Tda8Zfc8o1x_KwITRPWW65wMw0-tn3SnQQfTAAZ4_iU-681JuaDsCzMDMy-6EUy4VY_S0u74Yx1Sqq9GTMblA3BxIiCXlgBkDud_GimRytWImU_S5gfPi65KRxJmkO8z3GDfbSlxYxlpedS_Wbix4fnjPuh-fP32__NpfXX_5dnlx1XvJWe1Xcg1src2KK6q4hBCcXnkVjDJCtdhQBYIGqgdOpYHWqpeDMmZA5bVhjp91H_e6t8tqwuBxrtmN9jbHyeUHm1y0f2fmuLWbdGclUK6kaAJsL-DL4m1Gj9m7-kg8fnYXWieWCwYwNM67Q9Gcfi5Yqp1i8TiObsa0FAsMpGESFG3Qt_9Ab9KS57aSHUpIQbkwDQWHJtpeS8b1cQBG7c5mu7fZNpvto81WN9Kbp6MfKb9NbQC-B5SWmjeY_9T-j-wveAmyYg</recordid><startdate>20181026</startdate><enddate>20181026</enddate><creator>Ottino-González, J.</creator><creator>Jurado, M. A.</creator><creator>García-García, I.</creator><creator>Segura, B.</creator><creator>Marqués-Iturria, I.</creator><creator>Sender-Palacios, M. J.</creator><creator>Tor, E.</creator><creator>Prats-Soteras, X.</creator><creator>Caldú, X.</creator><creator>Junqué, C.</creator><creator>Pasternak, O.</creator><creator>Garolera, M.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>XX2</scope><scope>5PM</scope></search><sort><creationdate>20181026</creationdate><title>Allostatic load and disordered white matter microstructure in overweight adults</title><author>Ottino-González, J. ; Jurado, M. A. ; García-García, I. ; Segura, B. ; Marqués-Iturria, I. ; Sender-Palacios, M. J. ; Tor, E. ; Prats-Soteras, X. ; Caldú, X. ; Junqué, C. ; Pasternak, O. ; Garolera, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c631t-b6f21f89b3707362dda8bc7d97957da8907250d08430692110c647994e7c891a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>59/57</topic><topic>631/378/1488/393</topic><topic>631/378/1831</topic><topic>Anisotropy</topic><topic>Assaigs clínics</topic><topic>Biomarkers</topic><topic>Body mass index</topic><topic>Body weight</topic><topic>Brain</topic><topic>Brain injury</topic><topic>Central nervous system</topic><topic>Cervell</topic><topic>Clinical trials</topic><topic>Cytokines</topic><topic>Estrès (Fisiologia)</topic><topic>Homeostasis</topic><topic>Hormones</topic><topic>Humanities and Social Sciences</topic><topic>Inflammation</topic><topic>Metabolism</topic><topic>multidisciplinary</topic><topic>Obesitat</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Oxidative stress</topic><topic>Physiology</topic><topic>Precentral gyrus</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sistema nerviós central</topic><topic>Stress (Physiology)</topic><topic>Substantia alba</topic><topic>Substantia grisea</topic><topic>Thermogenesis</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ottino-González, J.</creatorcontrib><creatorcontrib>Jurado, M. A.</creatorcontrib><creatorcontrib>García-García, I.</creatorcontrib><creatorcontrib>Segura, B.</creatorcontrib><creatorcontrib>Marqués-Iturria, I.</creatorcontrib><creatorcontrib>Sender-Palacios, M. J.</creatorcontrib><creatorcontrib>Tor, E.</creatorcontrib><creatorcontrib>Prats-Soteras, X.</creatorcontrib><creatorcontrib>Caldú, X.</creatorcontrib><creatorcontrib>Junqué, C.</creatorcontrib><creatorcontrib>Pasternak, O.</creatorcontrib><creatorcontrib>Garolera, M.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Recercat</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ottino-González, J.</au><au>Jurado, M. A.</au><au>García-García, I.</au><au>Segura, B.</au><au>Marqués-Iturria, I.</au><au>Sender-Palacios, M. J.</au><au>Tor, E.</au><au>Prats-Soteras, X.</au><au>Caldú, X.</au><au>Junqué, C.</au><au>Pasternak, O.</au><au>Garolera, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allostatic load and disordered white matter microstructure in overweight adults</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-10-26</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>15898</spage><epage>12</epage><pages>15898-12</pages><artnum>15898</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Overweight and stress are both related to brain structural abnormalities. The allostatic load model states that frequent disruption of homeostasis is inherently linked to oxidative stress and inflammatory responses that in turn can damage the brain. However, the effects of the allostatic load on the central nervous system remain largely unknown. The current study aimed to assess the relationship between the allostatic load and the composition of whole-brain white matter tracts in overweight subjects. Additionally, we have also tested for grey matter changes regarding allostatic load increase. Thirty-one overweight-to-obese adults and 21 lean controls participated in the study. Our results showed that overweight participants presented higher allostatic load indexes. Such increases correlated with lower fractional anisotropy in the inferior fronto-occipital fasciculi and the right anterior corona radiata, as well as with grey matter reductions in the left precentral gyrus, the left lateral occipital gyrus, and the right pars opercularis. These results suggest that an otherwise healthy overweight status is linked to long-term biological changes potentially harmful to the brain.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30367110</pmid><doi>10.1038/s41598-018-34219-8</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2018-10, Vol.8 (1), p.15898-12, Article 15898 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6203765 |
| source | Nature Free; DOAJ Directory of Open Access Journals; Recercat; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; Springer Nature OA Free Journals |
| subjects | 59/57 631/378/1488/393 631/378/1831 Anisotropy Assaigs clínics Biomarkers Body mass index Body weight Brain Brain injury Central nervous system Cervell Clinical trials Cytokines Estrès (Fisiologia) Homeostasis Hormones Humanities and Social Sciences Inflammation Metabolism multidisciplinary Obesitat Obesity Overweight Oxidative stress Physiology Precentral gyrus Science Science (multidisciplinary) Sistema nerviós central Stress (Physiology) Substantia alba Substantia grisea Thermogenesis Weight control |
| title | Allostatic load and disordered white matter microstructure in overweight adults |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T20%3A34%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Allostatic%20load%20and%20disordered%20white%20matter%20microstructure%20in%20overweight%20adults&rft.jtitle=Scientific%20reports&rft.au=Ottino-Gonz%C3%A1lez,%20J.&rft.date=2018-10-26&rft.volume=8&rft.issue=1&rft.spage=15898&rft.epage=12&rft.pages=15898-12&rft.artnum=15898&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-018-34219-8&rft_dat=%3Cproquest_pubme%3E2126916270%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2125650359&rft_id=info:pmid/30367110&rfr_iscdi=true |