Dental pulp-derived stem cells can counterbalance peripheral nerve injury-induced oxidative stress and supraspinal neuro-inflammation in rat brain
Previously, we reported the successful regeneration of injured peripheral nerves using human dental pulp stem cells (DPSCs) or differentiated neuronal cells from DPSCs (DF-DPSCs) in a rat model. Here, we attempted to evaluate oxidative stress and supraspinal neuro-inflammation in rat brain after sci...
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| Veröffentlicht in: | Scientific reports 2018-10, Vol.8 (1), p.15795-10, Article 15795 |
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| creator | Ullah, Imran Choe, Yong-ho Khan, Mehtab Bharti, Dinesh Shivakumar, Sharath Belame Lee, Hyeon-Jeong Son, Young-Bum Shin, Yurianna Lee, Sung-Lim Park, Bong-Wook Ock, Sun-A Rho, Gyu-Jin |
| description | Previously, we reported the successful regeneration of injured peripheral nerves using human dental pulp stem cells (DPSCs) or differentiated neuronal cells from DPSCs (DF-DPSCs) in a rat model. Here, we attempted to evaluate oxidative stress and supraspinal neuro-inflammation in rat brain after sciatic nerve injury (SNI). We divided our experimental animals into three SNI groups based on time. The expression of a microglial (Iba1) marker and reactive oxygen species (ROS) was lower in DPSCs and higher in DF-DPSCs. In contrast, the expression of an astroglial (GFAP) marker was higher in DPSCs and lower in DF-DPSCs at 2 weeks. However, the expression of ROS, Iba1 and GFAP gradually decreased at 8 and 12 weeks in the SNI DPSCs and DF-DPSCs groups compared to the SNI control. Furthermore, anti-inflammatory cytokine (IL-4 and TGF-
β
) expression was lower at 2 weeks, while it gradually increased at 8 and 12 weeks after surgery in the SNI DPSCs and DF-DPSCs groups. Similarly, SNI DPSCs had a high expression of pAMPK, SIRT1 and NFkB at the onset of SNI. However, 12 weeks after surgery, pAMPK and SIRT1 expression levels were higher and NFkB was down-regulated in both DPSCs and DF-DPSCs compared to the control group. Finally, we concluded that DPSCs responded early and more efficiently than DF-DPSCs to counterbalance peripheral nerve injury (PNI)-induced oxidative stress and supraspinal neuro-inflammation in rat brain. |
| doi_str_mv | 10.1038/s41598-018-34151-x |
| format | Article |
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β
) expression was lower at 2 weeks, while it gradually increased at 8 and 12 weeks after surgery in the SNI DPSCs and DF-DPSCs groups. Similarly, SNI DPSCs had a high expression of pAMPK, SIRT1 and NFkB at the onset of SNI. However, 12 weeks after surgery, pAMPK and SIRT1 expression levels were higher and NFkB was down-regulated in both DPSCs and DF-DPSCs compared to the control group. Finally, we concluded that DPSCs responded early and more efficiently than DF-DPSCs to counterbalance peripheral nerve injury (PNI)-induced oxidative stress and supraspinal neuro-inflammation in rat brain.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-34151-x</identifier><identifier>PMID: 30361632</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/1 ; 13/51 ; 14 ; 45 ; 45/100 ; 631/532 ; 631/532/2074 ; 631/532/489 ; 82 ; Brain injury ; Dental pulp ; Glial fibrillary acidic protein ; Humanities and Social Sciences ; Inflammation ; Interleukin 4 ; multidisciplinary ; NF-κB protein ; Oxidative stress ; Peripheral nerves ; Reactive oxygen species ; Regeneration ; Rodents ; Sciatic nerve ; Science ; Science (multidisciplinary) ; SIRT1 protein ; Stem cell transplantation ; Stem cells ; Surgery</subject><ispartof>Scientific reports, 2018-10, Vol.8 (1), p.15795-10, Article 15795</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-1d65b74776631772415c44677ec8639de593974dca478ba5368e260672519f873</citedby><cites>FETCH-LOGICAL-c540t-1d65b74776631772415c44677ec8639de593974dca478ba5368e260672519f873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202384/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202384/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30361632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ullah, Imran</creatorcontrib><creatorcontrib>Choe, Yong-ho</creatorcontrib><creatorcontrib>Khan, Mehtab</creatorcontrib><creatorcontrib>Bharti, Dinesh</creatorcontrib><creatorcontrib>Shivakumar, Sharath Belame</creatorcontrib><creatorcontrib>Lee, Hyeon-Jeong</creatorcontrib><creatorcontrib>Son, Young-Bum</creatorcontrib><creatorcontrib>Shin, Yurianna</creatorcontrib><creatorcontrib>Lee, Sung-Lim</creatorcontrib><creatorcontrib>Park, Bong-Wook</creatorcontrib><creatorcontrib>Ock, Sun-A</creatorcontrib><creatorcontrib>Rho, Gyu-Jin</creatorcontrib><title>Dental pulp-derived stem cells can counterbalance peripheral nerve injury-induced oxidative stress and supraspinal neuro-inflammation in rat brain</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Previously, we reported the successful regeneration of injured peripheral nerves using human dental pulp stem cells (DPSCs) or differentiated neuronal cells from DPSCs (DF-DPSCs) in a rat model. Here, we attempted to evaluate oxidative stress and supraspinal neuro-inflammation in rat brain after sciatic nerve injury (SNI). We divided our experimental animals into three SNI groups based on time. The expression of a microglial (Iba1) marker and reactive oxygen species (ROS) was lower in DPSCs and higher in DF-DPSCs. In contrast, the expression of an astroglial (GFAP) marker was higher in DPSCs and lower in DF-DPSCs at 2 weeks. However, the expression of ROS, Iba1 and GFAP gradually decreased at 8 and 12 weeks in the SNI DPSCs and DF-DPSCs groups compared to the SNI control. Furthermore, anti-inflammatory cytokine (IL-4 and TGF-
β
) expression was lower at 2 weeks, while it gradually increased at 8 and 12 weeks after surgery in the SNI DPSCs and DF-DPSCs groups. Similarly, SNI DPSCs had a high expression of pAMPK, SIRT1 and NFkB at the onset of SNI. However, 12 weeks after surgery, pAMPK and SIRT1 expression levels were higher and NFkB was down-regulated in both DPSCs and DF-DPSCs compared to the control group. Finally, we concluded that DPSCs responded early and more efficiently than DF-DPSCs to counterbalance peripheral nerve injury (PNI)-induced oxidative stress and supraspinal neuro-inflammation in rat brain.</description><subject>13/1</subject><subject>13/51</subject><subject>14</subject><subject>45</subject><subject>45/100</subject><subject>631/532</subject><subject>631/532/2074</subject><subject>631/532/489</subject><subject>82</subject><subject>Brain injury</subject><subject>Dental pulp</subject><subject>Glial fibrillary acidic protein</subject><subject>Humanities and Social Sciences</subject><subject>Inflammation</subject><subject>Interleukin 4</subject><subject>multidisciplinary</subject><subject>NF-κB protein</subject><subject>Oxidative stress</subject><subject>Peripheral nerves</subject><subject>Reactive oxygen species</subject><subject>Regeneration</subject><subject>Rodents</subject><subject>Sciatic nerve</subject><subject>Science</subject><subject>Science 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Rep</addtitle><date>2018-10-25</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>15795</spage><epage>10</epage><pages>15795-10</pages><artnum>15795</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Previously, we reported the successful regeneration of injured peripheral nerves using human dental pulp stem cells (DPSCs) or differentiated neuronal cells from DPSCs (DF-DPSCs) in a rat model. Here, we attempted to evaluate oxidative stress and supraspinal neuro-inflammation in rat brain after sciatic nerve injury (SNI). We divided our experimental animals into three SNI groups based on time. The expression of a microglial (Iba1) marker and reactive oxygen species (ROS) was lower in DPSCs and higher in DF-DPSCs. In contrast, the expression of an astroglial (GFAP) marker was higher in DPSCs and lower in DF-DPSCs at 2 weeks. However, the expression of ROS, Iba1 and GFAP gradually decreased at 8 and 12 weeks in the SNI DPSCs and DF-DPSCs groups compared to the SNI control. Furthermore, anti-inflammatory cytokine (IL-4 and TGF-
β
) expression was lower at 2 weeks, while it gradually increased at 8 and 12 weeks after surgery in the SNI DPSCs and DF-DPSCs groups. Similarly, SNI DPSCs had a high expression of pAMPK, SIRT1 and NFkB at the onset of SNI. However, 12 weeks after surgery, pAMPK and SIRT1 expression levels were higher and NFkB was down-regulated in both DPSCs and DF-DPSCs compared to the control group. Finally, we concluded that DPSCs responded early and more efficiently than DF-DPSCs to counterbalance peripheral nerve injury (PNI)-induced oxidative stress and supraspinal neuro-inflammation in rat brain.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30361632</pmid><doi>10.1038/s41598-018-34151-x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13/1 13/51 14 45 45/100 631/532 631/532/2074 631/532/489 82 Brain injury Dental pulp Glial fibrillary acidic protein Humanities and Social Sciences Inflammation Interleukin 4 multidisciplinary NF-κB protein Oxidative stress Peripheral nerves Reactive oxygen species Regeneration Rodents Sciatic nerve Science Science (multidisciplinary) SIRT1 protein Stem cell transplantation Stem cells Surgery |
| title | Dental pulp-derived stem cells can counterbalance peripheral nerve injury-induced oxidative stress and supraspinal neuro-inflammation in rat brain |
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