Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells

RATIONALE:Human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) have risen as a useful tool in cardiovascular research, offering a wide gamut of translational and clinical applications. However, inefficiency of the currently available iPSC-EC differentiation protocol and underlyin...

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Veröffentlicht in:	Circulation research 2018-08, Vol.123 (4), p.443-450
Hauptverfasser:	Paik, David T, Tian, Lei, Lee, Jaecheol, Sayed, Nazish, Chen, Ian Y, Rhee, Siyeon, Rhee, June-Wha, Kim, Youngkyun, Wirka, Robert C, Buikema, Jan W, Wu, Sean M, Red-Horse, Kristy, Quertermous, Thomas, Wu, Joseph C
Format:	Artikel
Sprache:	eng
Schlagworte:	Apelin Receptors - genetics Apelin Receptors - metabolism Cell Differentiation Cells, Cultured Claudin-5 - genetics Claudin-5 - metabolism Connexins - genetics Connexins - metabolism Endothelial Cells - cytology Endothelial Cells - metabolism Gap Junction alpha-5 Protein Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Proteoglycans - genetics Proteoglycans - metabolism Single-Cell Analysis Transcriptome
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