A multiprotein supercomplex controlling oncogenic signalling in lymphoma

B cell receptor (BCR) signalling has emerged as a therapeutic target in B cell lymphomas, but inhibiting this pathway in diffuse large B cell lymphoma (DLBCL) has benefited only a subset of patients 1 . Gene expression profiling identified two major subtypes of DLBCL, known as germinal centre B cell...

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Veröffentlicht in:	Nature (London) 2018-08, Vol.560 (7718), p.387-391
Hauptverfasser:	Phelan, James D., Young, Ryan M., Webster, Daniel E., Roulland, Sandrine, Wright, George W., Kasbekar, Monica, Shaffer, Arthur L., Ceribelli, Michele, Wang, James Q., Schmitz, Roland, Nakagawa, Masao, Bachy, Emmanuel, Huang, Da Wei, Ji, Yanlong, Chen, Lu, Yang, Yandan, Zhao, Hong, Yu, Xin, Xu, Weihong, Palisoc, Maryknoll M., Valadez, Racquel R., Davies-Hill, Theresa, Wilson, Wyndham H., Chan, Wing C., Jaffe, Elaine S., Gascoyne, Randy D., Campo, Elias, Rosenwald, Andreas, Ott, German, Delabie, Jan, Rimsza, Lisa M., Rodriguez, Fausto J., Estephan, Fayez, Holdhoff, Matthias, Kruhlak, Michael J., Hewitt, Stephen M., Thomas, Craig J., Pittaluga, Stefania, Oellerich, Thomas, Staudt, Louis M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/516/1909 631/67/1990/291/1621/1915 82/58 96 96/63 96/95 Animals Autoantigens B cells B-cell lymphoma B-cell receptor Bcl-10 protein Biopsy Bruton's tyrosine kinase Cancer Carcinogenesis - genetics CRISPR CRISPR-Cas Systems - genetics Dependence Drug Design Female Gene expression Gene sequencing Genetic aspects Genomes Health aspects Humanities and Social Sciences Humans Immunology Inhibitors Kinases Letter Life Sciences Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - metabolism Lymphoma, Large B-Cell, Diffuse - pathology Lymphomas Mass spectrometry Mice multidisciplinary Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism Mutation MyD88 protein Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism NF-kappa B - metabolism NF-κB protein Protein kinase C Proteins Proteomics Pyrazoles - pharmacology Pyrazoles - therapeutic use Pyrimidines - pharmacology Pyrimidines - therapeutic use Receptors, Antigen, B-Cell - antagonists & inhibitors Receptors, Antigen, B-Cell - genetics Receptors, Antigen, B-Cell - metabolism Science Science (multidisciplinary) Scientific imaging Signal transduction Signal Transduction - drug effects Signal Transduction - genetics Signaling Syk protein Therapeutic applications TLR9 protein Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism Toll-like receptors TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Toxicity Tumor Cells, Cultured Tumors Xenograft Model Antitumor Assays
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