Determinants of neonatal brain-derived neurotrophic factor and association with child development
Using a population-based birth cohort in upstate New York (2008-2010), we examined the determinants of brain-derived neurotrophic factor (BDNF) measured in newborn dried blood spots (n = 2,637). We also examined the association between neonatal BDNF and children's development. The cohort was in...
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| Veröffentlicht in: | Development and psychopathology 2017-10, Vol.29 (4), p.1499-1511 |
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| creator | Ghassabian, Akhgar Sundaram, Rajeshwari Chahal, Nikhita McLain, Alexander C Bell, Erin Lawrence, David A Yeung, Edwina H |
| description | Using a population-based birth cohort in upstate New York (2008-2010), we examined the determinants of brain-derived neurotrophic factor (BDNF) measured in newborn dried blood spots (n = 2,637). We also examined the association between neonatal BDNF and children's development. The cohort was initially designed to examine the influence of infertility treatment on child development but found no impact. Mothers rated children's development in five domains repeatedly through age 3 years. Socioeconomic and maternal lifestyle determinants of BDNF were examined using multivariable linear regression models. Generalized linear mixed models estimated odds ratios for neonatal BDNF in relation to failing a developmental domain. Smoking and drinking in pregnancy, nulliparity, non-White ethnicity/race, and prepregnancy obesity were associated with lower neonatal BDNF. Neonatal BDNF was not associated with failure for developmental domains; however, there was an interaction between BDNF and preterm birth. In preterm infants, a higher BDNF was associated with lower odds of failing any developmental domains, after adjusting for confounders and infertility treatment. This result was particularly significant for failure in communication. Our findings suggest that BDNF levels in neonates may be impacted by maternal lifestyle characteristics. More specifically, lower neonatal BDNF might be an early marker of aberrant neurodevelopment in preterm infants. |
| doi_str_mv | 10.1017/S0954579417000414 |
| format | Article |
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We also examined the association between neonatal BDNF and children's development. The cohort was initially designed to examine the influence of infertility treatment on child development but found no impact. Mothers rated children's development in five domains repeatedly through age 3 years. Socioeconomic and maternal lifestyle determinants of BDNF were examined using multivariable linear regression models. Generalized linear mixed models estimated odds ratios for neonatal BDNF in relation to failing a developmental domain. Smoking and drinking in pregnancy, nulliparity, non-White ethnicity/race, and prepregnancy obesity were associated with lower neonatal BDNF. Neonatal BDNF was not associated with failure for developmental domains; however, there was an interaction between BDNF and preterm birth. In preterm infants, a higher BDNF was associated with lower odds of failing any developmental domains, after adjusting for confounders and infertility treatment. This result was particularly significant for failure in communication. Our findings suggest that BDNF levels in neonates may be impacted by maternal lifestyle characteristics. More specifically, lower neonatal BDNF might be an early marker of aberrant neurodevelopment in preterm infants.</description><identifier>ISSN: 0954-5794</identifier><identifier>EISSN: 1469-2198</identifier><identifier>DOI: 10.1017/S0954579417000414</identifier><identifier>PMID: 28462726</identifier><language>eng</language><publisher>United States: Cambridge University Press</publisher><subject>Age ; Biomarkers - blood ; Body mass index ; Brain research ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - blood ; Child development ; Child Development - physiology ; Child, Preschool ; Children ; Children & youth ; Cohort Studies ; Confidence intervals ; Drinking ; Female ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infants ; Infertility ; Male ; Minority & ethnic groups ; Mothers ; Neonates ; Neurodevelopment ; New York ; Newborn babies ; Pregnancy ; Premature birth ; Psychopathology ; Regression analysis ; Smoking</subject><ispartof>Development and psychopathology, 2017-10, Vol.29 (4), p.1499-1511</ispartof><rights>Copyright © Cambridge University Press 2017 This is a work of the US Government and is not subject to copyright protection in the United States.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-9baf092b23ddc6bdb1b24c3eb1f3ea27986e98810c17178b501a06e68d340bf53</citedby><cites>FETCH-LOGICAL-c427t-9baf092b23ddc6bdb1b24c3eb1f3ea27986e98810c17178b501a06e68d340bf53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28462726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghassabian, Akhgar</creatorcontrib><creatorcontrib>Sundaram, Rajeshwari</creatorcontrib><creatorcontrib>Chahal, Nikhita</creatorcontrib><creatorcontrib>McLain, Alexander C</creatorcontrib><creatorcontrib>Bell, Erin</creatorcontrib><creatorcontrib>Lawrence, David A</creatorcontrib><creatorcontrib>Yeung, Edwina H</creatorcontrib><title>Determinants of neonatal brain-derived neurotrophic factor and association with child development</title><title>Development and psychopathology</title><addtitle>Dev Psychopathol</addtitle><description>Using a population-based birth cohort in upstate New York (2008-2010), we examined the determinants of brain-derived neurotrophic factor (BDNF) measured in newborn dried blood spots (n = 2,637). We also examined the association between neonatal BDNF and children's development. The cohort was initially designed to examine the influence of infertility treatment on child development but found no impact. Mothers rated children's development in five domains repeatedly through age 3 years. Socioeconomic and maternal lifestyle determinants of BDNF were examined using multivariable linear regression models. Generalized linear mixed models estimated odds ratios for neonatal BDNF in relation to failing a developmental domain. Smoking and drinking in pregnancy, nulliparity, non-White ethnicity/race, and prepregnancy obesity were associated with lower neonatal BDNF. Neonatal BDNF was not associated with failure for developmental domains; however, there was an interaction between BDNF and preterm birth. In preterm infants, a higher BDNF was associated with lower odds of failing any developmental domains, after adjusting for confounders and infertility treatment. This result was particularly significant for failure in communication. Our findings suggest that BDNF levels in neonates may be impacted by maternal lifestyle characteristics. More specifically, lower neonatal BDNF might be an early marker of aberrant neurodevelopment in preterm infants.</description><subject>Age</subject><subject>Biomarkers - blood</subject><subject>Body mass index</subject><subject>Brain research</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Child development</subject><subject>Child Development - physiology</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Cohort Studies</subject><subject>Confidence intervals</subject><subject>Drinking</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infants</subject><subject>Infertility</subject><subject>Male</subject><subject>Minority & ethnic groups</subject><subject>Mothers</subject><subject>Neonates</subject><subject>Neurodevelopment</subject><subject>New York</subject><subject>Newborn babies</subject><subject>Pregnancy</subject><subject>Premature birth</subject><subject>Psychopathology</subject><subject>Regression analysis</subject><subject>Smoking</subject><issn>0954-5794</issn><issn>1469-2198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNplUcuKFTEQDaI419EPcCMBN25aU0k63dkIMuMLBlyo65BHtTdDd3JN0lf8e_sy4-BjVVDn1Kk6dQh5CuwlMBhefWa6l_2gJQyMMQnyHtmBVLrjoMf7ZHeCuxN-Rh7Ver1xeiH7h-SMj1LxgasdsZfYsCwx2dQqzRNNmJNtdqau2Ji6gCUeMWztteRW8mEfPZ2sb7lQmwK1tWYfbYs50R-x7anfxznQgEec82HB1B6TB5OdKz65refk67u3Xy4-dFef3n-8eHPVecmH1mlnJ6a54yIEr1xw4Lj0Ah1MAi0f9KhQjyMwDwMMo-sZWKZQjUFI5qZenJPXN7qH1S0Y_La62NkcSlxs-WmyjeZvJMW9-ZaPRnEGAtQm8OJWoOTvK9Zmllg9zrPdfrJWA6OWPWjOT7ue_0O9zmtJmz0DWoieaa34xoIbli-51oLT3THAzClA81-A28yzP13cTfxOTPwCAgiYJQ</recordid><startdate>20171001</startdate><enddate>20171001</enddate><creator>Ghassabian, Akhgar</creator><creator>Sundaram, Rajeshwari</creator><creator>Chahal, Nikhita</creator><creator>McLain, Alexander C</creator><creator>Bell, Erin</creator><creator>Lawrence, David A</creator><creator>Yeung, Edwina H</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AM</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGRYB</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K7.</scope><scope>K9.</scope><scope>M0O</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171001</creationdate><title>Determinants of neonatal brain-derived neurotrophic factor and association with child development</title><author>Ghassabian, Akhgar ; Sundaram, Rajeshwari ; Chahal, Nikhita ; McLain, Alexander C ; Bell, Erin ; Lawrence, David A ; Yeung, Edwina H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-9baf092b23ddc6bdb1b24c3eb1f3ea27986e98810c17178b501a06e68d340bf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Biomarkers - blood</topic><topic>Body mass index</topic><topic>Brain research</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Child development</topic><topic>Child Development - physiology</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Children & youth</topic><topic>Cohort Studies</topic><topic>Confidence intervals</topic><topic>Drinking</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infants</topic><topic>Infertility</topic><topic>Male</topic><topic>Minority & ethnic groups</topic><topic>Mothers</topic><topic>Neonates</topic><topic>Neurodevelopment</topic><topic>New York</topic><topic>Newborn babies</topic><topic>Pregnancy</topic><topic>Premature birth</topic><topic>Psychopathology</topic><topic>Regression analysis</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghassabian, Akhgar</creatorcontrib><creatorcontrib>Sundaram, Rajeshwari</creatorcontrib><creatorcontrib>Chahal, Nikhita</creatorcontrib><creatorcontrib>McLain, Alexander C</creatorcontrib><creatorcontrib>Bell, Erin</creatorcontrib><creatorcontrib>Lawrence, David A</creatorcontrib><creatorcontrib>Yeung, Edwina H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Criminal Justice Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Criminology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Criminal Justice</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Development and psychopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghassabian, Akhgar</au><au>Sundaram, Rajeshwari</au><au>Chahal, Nikhita</au><au>McLain, Alexander C</au><au>Bell, Erin</au><au>Lawrence, David A</au><au>Yeung, Edwina H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determinants of neonatal brain-derived neurotrophic factor and association with child development</atitle><jtitle>Development and psychopathology</jtitle><addtitle>Dev Psychopathol</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>29</volume><issue>4</issue><spage>1499</spage><epage>1511</epage><pages>1499-1511</pages><issn>0954-5794</issn><eissn>1469-2198</eissn><abstract>Using a population-based birth cohort in upstate New York (2008-2010), we examined the determinants of brain-derived neurotrophic factor (BDNF) measured in newborn dried blood spots (n = 2,637). We also examined the association between neonatal BDNF and children's development. The cohort was initially designed to examine the influence of infertility treatment on child development but found no impact. Mothers rated children's development in five domains repeatedly through age 3 years. Socioeconomic and maternal lifestyle determinants of BDNF were examined using multivariable linear regression models. Generalized linear mixed models estimated odds ratios for neonatal BDNF in relation to failing a developmental domain. Smoking and drinking in pregnancy, nulliparity, non-White ethnicity/race, and prepregnancy obesity were associated with lower neonatal BDNF. Neonatal BDNF was not associated with failure for developmental domains; however, there was an interaction between BDNF and preterm birth. In preterm infants, a higher BDNF was associated with lower odds of failing any developmental domains, after adjusting for confounders and infertility treatment. This result was particularly significant for failure in communication. Our findings suggest that BDNF levels in neonates may be impacted by maternal lifestyle characteristics. More specifically, lower neonatal BDNF might be an early marker of aberrant neurodevelopment in preterm infants.</abstract><cop>United States</cop><pub>Cambridge University Press</pub><pmid>28462726</pmid><doi>10.1017/S0954579417000414</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Biomarkers - blood Body mass index Brain research Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood Child development Child Development - physiology Child, Preschool Children Children & youth Cohort Studies Confidence intervals Drinking Female Humans Infant Infant, Newborn Infant, Premature Infants Infertility Male Minority & ethnic groups Mothers Neonates Neurodevelopment New York Newborn babies Pregnancy Premature birth Psychopathology Regression analysis Smoking |
| title | Determinants of neonatal brain-derived neurotrophic factor and association with child development |
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