Absence of a High Level of Duplication of the Plasmepsin II Gene in Africa

Resistance to piperaquine has been associated with the amplification of the plasmepsin II gene in Cambodia. None of the 175 African isolates that we analyzed had plasmepsin II gene amplification (piperaquine 50% inhibitory concentration ranged from 0.94 to 137.5 nM), suggesting there is a low preval...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2018-11, Vol.62 (11)
Hauptverfasser:	Robert, Marie Gladys, Foguim Tsombeng, Francis, Gendrot, Mathieu, Mosnier, Joel, Amalvict, Rémy, Benoit, Nicolas, Torrentino-Madamet, Marylin, Pradines, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspartic Acid Endopeptidases Epidemiology and Surveillance Protozoan Proteins
Online-Zugang:	Volltext
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