ICAM-1 gene rs5498 polymorphism decreases the risk of coronary artery disease
Many studies investigated the association between intercellular adhesion molecule 1 (ICAM-1) gene rs5498 polymorphism and the risk of coronary artery disease (CAD). However, the results were inconsistent. To clarify convincing association, we conducted a comprehensive meta-analysis by searching in P...
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| Veröffentlicht in: | Medicine (Baltimore) 2018-10, Vol.97 (40), p.e12523-e12523 |
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| creator | Liu, Ailing Wan, Ailing Feng, Aifang Rui, Ruping Zhou, Bingzhi |
| description | Many studies investigated the association between intercellular adhesion molecule 1 (ICAM-1) gene rs5498 polymorphism and the risk of coronary artery disease (CAD). However, the results were inconsistent.
To clarify convincing association, we conducted a comprehensive meta-analysis by searching in PubMed, Embase, Web of sciences, Sciences citation index, Google scholar, Cochrane Library, and the CNKI databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
A total of 29 case-control studies with 5,494 cases and 6,364 controls for rs5498 polymorphism were included. The studied populations of this meta-analysis included Caucasians and Asians. Meta-analysis showed that rs5498 polymorphism was associated with the decreased risk of CAD. Stratification analysis of ethnicity found that rs5498 polymorphism decreased the risk of CAD among Caucasians, but not among Asians. Stratification by type of CAD revealed that ICAM-1 gene rs5498 polymorphism was also correlated with the decreased risk of myocardial infarction (MI).
In conclusion, this meta-analysis indicates that ICAM-1 gene rs5498 polymorphism decreases the risk of CAD. |
| doi_str_mv | 10.1097/MD.0000000000012523 |
| format | Article |
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To clarify convincing association, we conducted a comprehensive meta-analysis by searching in PubMed, Embase, Web of sciences, Sciences citation index, Google scholar, Cochrane Library, and the CNKI databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
A total of 29 case-control studies with 5,494 cases and 6,364 controls for rs5498 polymorphism were included. The studied populations of this meta-analysis included Caucasians and Asians. Meta-analysis showed that rs5498 polymorphism was associated with the decreased risk of CAD. Stratification analysis of ethnicity found that rs5498 polymorphism decreased the risk of CAD among Caucasians, but not among Asians. Stratification by type of CAD revealed that ICAM-1 gene rs5498 polymorphism was also correlated with the decreased risk of myocardial infarction (MI).
In conclusion, this meta-analysis indicates that ICAM-1 gene rs5498 polymorphism decreases the risk of CAD.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000012523</identifier><identifier>PMID: 30290609</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Asian Continental Ancestry Group - genetics ; Case-Control Studies ; Coronary Artery Disease - ethnology ; Coronary Artery Disease - genetics ; European Continental Ancestry Group - genetics ; Genetic Predisposition to Disease ; Genotype ; Humans ; Intercellular Adhesion Molecule-1 - genetics ; Myocardial Infarction - ethnology ; Myocardial Infarction - genetics ; Polymorphism, Single Nucleotide ; Risk Factors ; Systematic Review and Meta-Analysis</subject><ispartof>Medicine (Baltimore), 2018-10, Vol.97 (40), p.e12523-e12523</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4503-e2d723ecbe243d24a58d010aa1e37354fd76f2dc3847e7a8f87ee7ebde3da2d23</citedby><cites>FETCH-LOGICAL-c4503-e2d723ecbe243d24a58d010aa1e37354fd76f2dc3847e7a8f87ee7ebde3da2d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200538/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200538/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30290609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Ailing</creatorcontrib><creatorcontrib>Wan, Ailing</creatorcontrib><creatorcontrib>Feng, Aifang</creatorcontrib><creatorcontrib>Rui, Ruping</creatorcontrib><creatorcontrib>Zhou, Bingzhi</creatorcontrib><title>ICAM-1 gene rs5498 polymorphism decreases the risk of coronary artery disease</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Many studies investigated the association between intercellular adhesion molecule 1 (ICAM-1) gene rs5498 polymorphism and the risk of coronary artery disease (CAD). However, the results were inconsistent.
To clarify convincing association, we conducted a comprehensive meta-analysis by searching in PubMed, Embase, Web of sciences, Sciences citation index, Google scholar, Cochrane Library, and the CNKI databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
A total of 29 case-control studies with 5,494 cases and 6,364 controls for rs5498 polymorphism were included. The studied populations of this meta-analysis included Caucasians and Asians. Meta-analysis showed that rs5498 polymorphism was associated with the decreased risk of CAD. Stratification analysis of ethnicity found that rs5498 polymorphism decreased the risk of CAD among Caucasians, but not among Asians. Stratification by type of CAD revealed that ICAM-1 gene rs5498 polymorphism was also correlated with the decreased risk of myocardial infarction (MI).
In conclusion, this meta-analysis indicates that ICAM-1 gene rs5498 polymorphism decreases the risk of CAD.</description><subject>Asian Continental Ancestry Group - genetics</subject><subject>Case-Control Studies</subject><subject>Coronary Artery Disease - ethnology</subject><subject>Coronary Artery Disease - genetics</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Intercellular Adhesion Molecule-1 - genetics</subject><subject>Myocardial Infarction - ethnology</subject><subject>Myocardial Infarction - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><subject>Systematic Review and Meta-Analysis</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctOwzAQRS0EoqXwBUgoSzYpfsbJBglRXlIrNrC23HjShCZxsVOq_j0uLeUxmxnZZ-6M7iB0TvCQ4ExeTUZD_BOECsoOUJ8IlsQiS_gh6mNMRSwzyXvoxPu3ADFJ-THqMUwznOCsjyZPtzeTmEQzaCFyXvAsjRa2XjfWLcrKN5GB3IH24KOuDETl55Etotw622q3jrTrICRT-Q10io4KXXs42-UBer2_e7l9jMfPD2HQOM65wCwGaiRlkE-BcmYo1yI1mGCtCTDJBC-MTApqcpZyCVKnRSoBJEwNMKOpoWyArre6i-W0AZND2zldq4WrmrCUsrpSf3_aqlQz-6ESirFgaRC43Ak4-74E36mm8jnUtW7BLr2ihCSpCIaRgLItmjvrvYNiP4ZgtTmEmozU_0OErovfG-57vp0PAN8CK1sHC_28Xq7AqRJ03ZVfekJmNKaYpCTUOA4vQfcTbVGTZw</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Liu, Ailing</creator><creator>Wan, Ailing</creator><creator>Feng, Aifang</creator><creator>Rui, Ruping</creator><creator>Zhou, Bingzhi</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181001</creationdate><title>ICAM-1 gene rs5498 polymorphism decreases the risk of coronary artery disease</title><author>Liu, Ailing ; Wan, Ailing ; Feng, Aifang ; Rui, Ruping ; Zhou, Bingzhi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4503-e2d723ecbe243d24a58d010aa1e37354fd76f2dc3847e7a8f87ee7ebde3da2d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Asian Continental Ancestry Group - genetics</topic><topic>Case-Control Studies</topic><topic>Coronary Artery Disease - ethnology</topic><topic>Coronary Artery Disease - genetics</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Intercellular Adhesion Molecule-1 - genetics</topic><topic>Myocardial Infarction - ethnology</topic><topic>Myocardial Infarction - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><topic>Systematic Review and Meta-Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Ailing</creatorcontrib><creatorcontrib>Wan, Ailing</creatorcontrib><creatorcontrib>Feng, Aifang</creatorcontrib><creatorcontrib>Rui, Ruping</creatorcontrib><creatorcontrib>Zhou, Bingzhi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Ailing</au><au>Wan, Ailing</au><au>Feng, Aifang</au><au>Rui, Ruping</au><au>Zhou, Bingzhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ICAM-1 gene rs5498 polymorphism decreases the risk of coronary artery disease</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>97</volume><issue>40</issue><spage>e12523</spage><epage>e12523</epage><pages>e12523-e12523</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Many studies investigated the association between intercellular adhesion molecule 1 (ICAM-1) gene rs5498 polymorphism and the risk of coronary artery disease (CAD). However, the results were inconsistent.
To clarify convincing association, we conducted a comprehensive meta-analysis by searching in PubMed, Embase, Web of sciences, Sciences citation index, Google scholar, Cochrane Library, and the CNKI databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
A total of 29 case-control studies with 5,494 cases and 6,364 controls for rs5498 polymorphism were included. The studied populations of this meta-analysis included Caucasians and Asians. Meta-analysis showed that rs5498 polymorphism was associated with the decreased risk of CAD. Stratification analysis of ethnicity found that rs5498 polymorphism decreased the risk of CAD among Caucasians, but not among Asians. Stratification by type of CAD revealed that ICAM-1 gene rs5498 polymorphism was also correlated with the decreased risk of myocardial infarction (MI).
In conclusion, this meta-analysis indicates that ICAM-1 gene rs5498 polymorphism decreases the risk of CAD.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>30290609</pmid><doi>10.1097/MD.0000000000012523</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Asian Continental Ancestry Group - genetics Case-Control Studies Coronary Artery Disease - ethnology Coronary Artery Disease - genetics European Continental Ancestry Group - genetics Genetic Predisposition to Disease Genotype Humans Intercellular Adhesion Molecule-1 - genetics Myocardial Infarction - ethnology Myocardial Infarction - genetics Polymorphism, Single Nucleotide Risk Factors Systematic Review and Meta-Analysis |
| title | ICAM-1 gene rs5498 polymorphism decreases the risk of coronary artery disease |
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