Structure–Function Analyses of the N‑Butanoyl l‑Homoserine Lactone Quorum-Sensing Signal Define Features Critical to Activity in RhlR

Pseudomonas aeruginosa is an opportunistic pathogen that coordinates the production of many virulence phenotypes at high population density via quorum sensing (QS). The LuxR-type receptor RhlR plays an important role in the P. aeruginosa QS process, and there is considerable interest in the developm...

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Veröffentlicht in:	ACS chemical biology 2018-09, Vol.13 (9), p.2655-2662
Hauptverfasser:	Boursier, Michelle E, Moore, Joseph D, Heitman, Katherine M, Shepardson-Fungairino, Sally P, Combs, Joshua B, Koenig, Lea C, Shin, Daniel, Brown, Eric C, Nagarajan, Rajesh, Blackwell, Helen E
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - chemistry 4-Butyrolactone - pharmacology Bacterial Proteins - agonists Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - metabolism Humans Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - physiology Pseudomonas Infections - microbiology Quorum Sensing - drug effects Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology
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