The Promising Effects of Transplanted Umbilical Cord Mesenchymal Stem Cells on the Treatment in Traumatic Brain Injury
Many studies have reported the recovery ability of umbilical cord-derived mesenchymal stem cells (UC-MSCs) for neural diseases. In this study, the authors explored the roles of UC-MSCs to treat the traumatic brain injury. Umbilical cord-derived mesenchymal stem cells were isolated from healthy neona...
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| Veröffentlicht in: | The Journal of craniofacial surgery 2018-10, Vol.29 (7), p.1689-1692 |
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| creator | Qi, Lifeng Xue, Xinhong Sun, Jijun Wu, Qingjian Wang, Hongru Guo, Yan Sun, Baoliang |
| description | Many studies have reported the recovery ability of umbilical cord-derived mesenchymal stem cells (UC-MSCs) for neural diseases. In this study, the authors explored the roles of UC-MSCs to treat the traumatic brain injury. Umbilical cord-derived mesenchymal stem cells were isolated from healthy neonatal rat umbilical cord immediately after delivery. The traumatic brain injury (TBI) model was formed by the classical gravity method. The authors detected the behavior changes and measured the levels of inflammatory factors, such as interleukin-lβ and tumor necrosis factor-α by enzyme linked immunosorbent assay (ELISA) at 1, 2, 3, 4 weeks after transplantation between TBI treated and untreated with UC-MSCs. Simultaneously, the expression of glial cell line-derived neurotrophic factor (GDNF) and brain derived neurotrophic factor (BDNF) were measured by real-time-polymerase chain reaction and ELISA.The authors found that the group of transplantation UC-MSCs has a significant improvement than other group treated by phosphate buffered saline. In the behavioral test, the Neurological Severity Scores of UC-MSCs + TBI group were lower than TBI group (P |
| doi_str_mv | 10.1097/SCS.0000000000005042 |
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In this study, the authors explored the roles of UC-MSCs to treat the traumatic brain injury. Umbilical cord-derived mesenchymal stem cells were isolated from healthy neonatal rat umbilical cord immediately after delivery. The traumatic brain injury (TBI) model was formed by the classical gravity method. The authors detected the behavior changes and measured the levels of inflammatory factors, such as interleukin-lβ and tumor necrosis factor-α by enzyme linked immunosorbent assay (ELISA) at 1, 2, 3, 4 weeks after transplantation between TBI treated and untreated with UC-MSCs. Simultaneously, the expression of glial cell line-derived neurotrophic factor (GDNF) and brain derived neurotrophic factor (BDNF) were measured by real-time-polymerase chain reaction and ELISA.The authors found that the group of transplantation UC-MSCs has a significant improvement than other group treated by phosphate buffered saline. In the behavioral test, the Neurological Severity Scores of UC-MSCs + TBI group were lower than TBI group (P < 0.05), but not obviously higher than control group at 2, 3, and 4week, respectively. The inflammatory factors are significantly reduced comparison with TBI group (P < 0.05), but both GDNF and BDNF were higher than TBI group (P < 0.05). The results indicated that UC-MSCs might play an important role in TBI recovery through inhibiting the release of inflammatory factors and increasing the expression of GDNF and BDNF.</description><identifier>ISSN: 1049-2275</identifier><identifier>EISSN: 1536-3732</identifier><identifier>DOI: 10.1097/SCS.0000000000005042</identifier><identifier>PMID: 30234712</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Animals ; Behavior, Animal ; Brain Injuries, Traumatic - metabolism ; Brain Injuries, Traumatic - therapy ; Brain-Derived Neurotrophic Factor - genetics ; Brain-Derived Neurotrophic Factor - metabolism ; Dentistry ; Glial Cell Line-Derived Neurotrophic Factor - genetics ; Glial Cell Line-Derived Neurotrophic Factor - metabolism ; Interleukin-1beta - metabolism ; Male ; Mesenchymal Stem Cell Transplantation ; Original ; Rats ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha - metabolism ; Umbilical Cord - cytology</subject><ispartof>The Journal of craniofacial surgery, 2018-10, Vol.29 (7), p.1689-1692</ispartof><rights>Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of Mutaz B. Habal, MD. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-6e018bf444b4fd433223c298245106884b15dcf53d36753522a6b56902820b203</citedby><cites>FETCH-LOGICAL-c525t-6e018bf444b4fd433223c298245106884b15dcf53d36753522a6b56902820b203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30234712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qi, Lifeng</creatorcontrib><creatorcontrib>Xue, Xinhong</creatorcontrib><creatorcontrib>Sun, Jijun</creatorcontrib><creatorcontrib>Wu, Qingjian</creatorcontrib><creatorcontrib>Wang, Hongru</creatorcontrib><creatorcontrib>Guo, Yan</creatorcontrib><creatorcontrib>Sun, Baoliang</creatorcontrib><title>The Promising Effects of Transplanted Umbilical Cord Mesenchymal Stem Cells on the Treatment in Traumatic Brain Injury</title><title>The Journal of craniofacial surgery</title><addtitle>J Craniofac Surg</addtitle><description>Many studies have reported the recovery ability of umbilical cord-derived mesenchymal stem cells (UC-MSCs) for neural diseases. In this study, the authors explored the roles of UC-MSCs to treat the traumatic brain injury. Umbilical cord-derived mesenchymal stem cells were isolated from healthy neonatal rat umbilical cord immediately after delivery. The traumatic brain injury (TBI) model was formed by the classical gravity method. The authors detected the behavior changes and measured the levels of inflammatory factors, such as interleukin-lβ and tumor necrosis factor-α by enzyme linked immunosorbent assay (ELISA) at 1, 2, 3, 4 weeks after transplantation between TBI treated and untreated with UC-MSCs. Simultaneously, the expression of glial cell line-derived neurotrophic factor (GDNF) and brain derived neurotrophic factor (BDNF) were measured by real-time-polymerase chain reaction and ELISA.The authors found that the group of transplantation UC-MSCs has a significant improvement than other group treated by phosphate buffered saline. In the behavioral test, the Neurological Severity Scores of UC-MSCs + TBI group were lower than TBI group (P < 0.05), but not obviously higher than control group at 2, 3, and 4week, respectively. The inflammatory factors are significantly reduced comparison with TBI group (P < 0.05), but both GDNF and BDNF were higher than TBI group (P < 0.05). The results indicated that UC-MSCs might play an important role in TBI recovery through inhibiting the release of inflammatory factors and increasing the expression of GDNF and BDNF.</description><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Brain Injuries, Traumatic - metabolism</subject><subject>Brain Injuries, Traumatic - therapy</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Dentistry</subject><subject>Glial Cell Line-Derived Neurotrophic Factor - genetics</subject><subject>Glial Cell Line-Derived Neurotrophic Factor - metabolism</subject><subject>Interleukin-1beta - metabolism</subject><subject>Male</subject><subject>Mesenchymal Stem Cell Transplantation</subject><subject>Original</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Umbilical Cord - cytology</subject><issn>1049-2275</issn><issn>1536-3732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1vGyEQhlHVqEmd_oOq4tjLOjB87PpSqV0ljaVUiWT7jFiWjYl2WRfYSP73wbIbJeUyMMz7MMyL0FdK5pQsyqtVvZqTN0sQDh_QBRVMFqxk8DHvCV8UAKU4R59jfCIEKAX5CZ0zAoyXFC7Q83pr8UMYBxedf8TXXWdNinjs8DpoH3e99sm2eDM0rndG97geQ4v_2Gi92e6HnFglO-Da9n1WeZwybh2sToP1CTt_wEyDTs7gX0Hn89I_TWF_ic463Uf75RRnaHNzva5vi7v738v6511hBIhUSEto1XSc84Z3LWcMgBlYVMAFJbKqeENFazrBWiZLwQSAlo2QCwIVkAYIm6EfR-5uagbbmtxU0L3aBTfosFejdur9jXdb9Tg-KwmEsIycoe8nQBj_TjYmlSdl8m-1t-MUVZ6orDireJlL-bHUhDHGYLvXZyhRB8tUtkz9b1mWfXvb4qvon0fsBQeHkco</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Qi, Lifeng</creator><creator>Xue, Xinhong</creator><creator>Sun, Jijun</creator><creator>Wu, Qingjian</creator><creator>Wang, Hongru</creator><creator>Guo, Yan</creator><creator>Sun, Baoliang</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181001</creationdate><title>The Promising Effects of Transplanted Umbilical Cord Mesenchymal Stem Cells on the Treatment in Traumatic Brain Injury</title><author>Qi, Lifeng ; Xue, Xinhong ; Sun, Jijun ; Wu, Qingjian ; Wang, Hongru ; Guo, Yan ; Sun, Baoliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-6e018bf444b4fd433223c298245106884b15dcf53d36753522a6b56902820b203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Brain Injuries, Traumatic - metabolism</topic><topic>Brain Injuries, Traumatic - therapy</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Dentistry</topic><topic>Glial Cell Line-Derived Neurotrophic Factor - genetics</topic><topic>Glial Cell Line-Derived Neurotrophic Factor - metabolism</topic><topic>Interleukin-1beta - metabolism</topic><topic>Male</topic><topic>Mesenchymal Stem Cell Transplantation</topic><topic>Original</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Umbilical Cord - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qi, Lifeng</creatorcontrib><creatorcontrib>Xue, Xinhong</creatorcontrib><creatorcontrib>Sun, Jijun</creatorcontrib><creatorcontrib>Wu, Qingjian</creatorcontrib><creatorcontrib>Wang, Hongru</creatorcontrib><creatorcontrib>Guo, Yan</creatorcontrib><creatorcontrib>Sun, Baoliang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of craniofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qi, Lifeng</au><au>Xue, Xinhong</au><au>Sun, Jijun</au><au>Wu, Qingjian</au><au>Wang, Hongru</au><au>Guo, Yan</au><au>Sun, Baoliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Promising Effects of Transplanted Umbilical Cord Mesenchymal Stem Cells on the Treatment in Traumatic Brain Injury</atitle><jtitle>The Journal of craniofacial surgery</jtitle><addtitle>J Craniofac Surg</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>29</volume><issue>7</issue><spage>1689</spage><epage>1692</epage><pages>1689-1692</pages><issn>1049-2275</issn><eissn>1536-3732</eissn><abstract>Many studies have reported the recovery ability of umbilical cord-derived mesenchymal stem cells (UC-MSCs) for neural diseases. In this study, the authors explored the roles of UC-MSCs to treat the traumatic brain injury. Umbilical cord-derived mesenchymal stem cells were isolated from healthy neonatal rat umbilical cord immediately after delivery. The traumatic brain injury (TBI) model was formed by the classical gravity method. The authors detected the behavior changes and measured the levels of inflammatory factors, such as interleukin-lβ and tumor necrosis factor-α by enzyme linked immunosorbent assay (ELISA) at 1, 2, 3, 4 weeks after transplantation between TBI treated and untreated with UC-MSCs. Simultaneously, the expression of glial cell line-derived neurotrophic factor (GDNF) and brain derived neurotrophic factor (BDNF) were measured by real-time-polymerase chain reaction and ELISA.The authors found that the group of transplantation UC-MSCs has a significant improvement than other group treated by phosphate buffered saline. In the behavioral test, the Neurological Severity Scores of UC-MSCs + TBI group were lower than TBI group (P < 0.05), but not obviously higher than control group at 2, 3, and 4week, respectively. The inflammatory factors are significantly reduced comparison with TBI group (P < 0.05), but both GDNF and BDNF were higher than TBI group (P < 0.05). The results indicated that UC-MSCs might play an important role in TBI recovery through inhibiting the release of inflammatory factors and increasing the expression of GDNF and BDNF.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>30234712</pmid><doi>10.1097/SCS.0000000000005042</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Behavior, Animal Brain Injuries, Traumatic - metabolism Brain Injuries, Traumatic - therapy Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Dentistry Glial Cell Line-Derived Neurotrophic Factor - genetics Glial Cell Line-Derived Neurotrophic Factor - metabolism Interleukin-1beta - metabolism Male Mesenchymal Stem Cell Transplantation Original Rats Rats, Sprague-Dawley Tumor Necrosis Factor-alpha - metabolism Umbilical Cord - cytology |
| title | The Promising Effects of Transplanted Umbilical Cord Mesenchymal Stem Cells on the Treatment in Traumatic Brain Injury |
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