A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain

More than 4 million children are exposed annually to sedatives and general anaesthetics (GAs) in the USA alone. Recent data suggest that common GAs can be detrimental to brain development causing neurodegeneration and long-term cognitive impairments. Challenged by a recent US Food and Drug Administr...

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Veröffentlicht in:	British journal of anaesthesia : BJA 2018-04, Vol.120 (4), p.768-778
Hauptverfasser:	Atluri, N., Joksimovic, S.M., Oklopcic, A., Milanovic, D., Klawitter, J., Eggan, P., Krishnan, K., Covey, D.F., Todorovic, S.M., Jevtovic-Todorovic, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstanols - pharmacology Animals Brain - drug effects Calcium Channel Blockers - pharmacology calcium channels Calcium Channels, T-Type developmental neurotoxicity Hypnotics and Sedatives - pharmacology Models, Animal Neuroscience and Neuroanaesthesia neurosteroid Nitriles - pharmacology Rats Rats, Sprague-Dawley
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