Epithelial Cdc42 Deletion Induced Enamel Organ Defects and Cystogenesis

Cdc42, a Rho family small GTPase, regulates cytoskeleton organization, vesicle trafficking, and other cellular processes in development and homeostasis. However, Cdc42’s roles in prenatal tooth development remain elusive. Here, we investigated Cdc42 functions in mouse enamel organ. Cdc42 showed high...

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Veröffentlicht in:	Journal of dental research 2018-11, Vol.97 (12), p.1346-1354
Hauptverfasser:	Zheng, J., Nie, X., He, L., Yoon, A.J., Wu, L., Zhang, X., Vats, M., Schiff, M.D., Xiang, L., Tian, Z., Ling, J., Mao, J.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Ameloblasts - metabolism Animals Apoptosis Autophagosomes - metabolism Blotting, Western Cdc42 protein Cell death Cell Differentiation Cell junctions Cell survival Clonal deletion Cysts - embryology Cytoskeletal Proteins Cytoskeleton Data analysis Defects Dental enamel Desmosomes Embryos Enamel Enamel Organ - embryology Epithelium Epithelium - embryology Gestation Guanosine triphosphatases Homeostasis Immunoglobulins In Situ Nick-End Labeling Intercellular Junctions - metabolism Kinases Laboratories Lesions Mice Microscopy Microscopy, Electron, Transmission Morphogenesis Phagosomes Protocol Real-Time Polymerase Chain Reaction Research Reports rho GTP-Binding Proteins - metabolism Teeth Transmission electron microscopy Wnt protein β-Catenin
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