The CaspBase: a curated database for evolutionary biochemical studies of caspase functional divergence and ancestral sequence inference

Sequence databases are powerful tools for the contemporary scientists’ toolkit. However, most functional annotations in public databases are determined computationally and are not verified by a human expert. While hypotheses generated from computational studies are now amenable to experimentation, t...

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Veröffentlicht in:	Protein science 2018-10, Vol.27 (10), p.1857-1870
Hauptverfasser:	Grinshpon, Robert D., Williford, Anna, Titus‐McQuillan, James, Clay Clark, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Amino acids ancestral protein reconstruction Annotations Caspase Caspases - chemistry Caspases - genetics Caspases - metabolism Computational Biology Computer applications Data banks database curation Databases, Protein Divergence Experimentation Humans Models, Molecular Noise reduction Nucleotide sequence Phylogeny protein evolution Proteins Sequence Alignment sequence analysis Sequence Analysis, Protein Structure-function relationships Tools for Protein Science Upgrading
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