Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci

To assess the impact of genetic variation in regulatory loci on human health, we constructed a high-resolution map of allelic imbalances in DNA methylation, histone marks, and gene transcription in 71 epigenomes from 36 distinct cell and tissue types from 13 donors. Deep whole-genome bisulfite seque...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-09, Vol.361 (6409)
Hauptverfasser:	Onuchic, Vitor, Lurie, Eugene, Carrero, Ivenise, Pawliczek, Piotr, Patel, Ronak Y, Rozowsky, Joel, Galeev, Timur, Huang, Zhuoyi, Altshuler, Robert C, Zhang, Zhizhuo, Harris, R Alan, Coarfa, Cristian, Ashmore, Lillian, Bertol, Jessica W, Fakhouri, Walid D, Yu, Fuli, Kellis, Manolis, Gerstein, Mark, Milosavljevic, Aleksandar
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Allelic Imbalance Binding Sites Biological evolution Bisulfite Buffers Chromosomes Circuits CpG Islands Deoxyribonucleic acid Disease - genetics DNA DNA Methylation Donors Epigenesis, Genetic Gene expression Gene mapping Gene regulation Gene Regulatory Networks Gene sequencing Genes Genetic diversity Genetic Loci Genetic variance Genetics Genome, Human Genome-Wide Association Study Genomes Homology Humans Innovations Loci Mutation Nucleotide sequence Polymorphism, Single Nucleotide Regulatory sequences Sensitivity Sequence Analysis, DNA Sulfites - chemistry Switches Switching Transcription factors Transcription Factors - metabolism
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