Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell

Store-operated Ca entry (SOCE) is a dynamic process that leads to refilling of endoplasmic reticulum (ER) Ca stores through reversible gating of plasma membrane Ca channels by the ER Ca sensor Stromal Interaction Molecule 1 (STIM1). Pathogenic reductions in β-cell ER Ca have been observed in diabete...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2018-11, Vol.67 (11), p.2293-2304
Hauptverfasser:	Kono, Tatsuyoshi, Tong, Xin, Taleb, Solaema, Bone, Robert N, Iida, Hitoshi, Lee, Chih-Chun, Sohn, Paul, Gilon, Patrick, Roe, Michael W, Evans-Molina, Carmella
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Calcium Calcium (reticular) Calcium - metabolism Calcium channels Calcium homeostasis Calcium influx Calcium signalling Cell Line Cell survival Channel gating Clonal deletion Cytokines Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Experimental - metabolism Endoplasmic reticulum Endoplasmic Reticulum Stress - physiology Glucose - pharmacology Humans Inflammation Insulin Insulin - metabolism Insulin secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulinoma Islet Studies Islets of Langerhans Lymphocytes Mice mRNA Neuroendocrine tumors Palmitic acid Phenotypes Rats STIM1 protein Stromal Interaction Molecule 1 - genetics Stromal Interaction Molecule 1 - metabolism
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