Fisetin is a senotherapeutic that extends health and lifespan

Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmacologic approaches. We previously demonstrated that the combina...

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Veröffentlicht in:	EBioMedicine 2018-10, Vol.36, p.18-28
Hauptverfasser:	Yousefzadeh, Matthew J., Zhu, Yi, McGowan, Sara J., Angelini, Luise, Fuhrmann-Stroissnigg, Heike, Xu, Ming, Ling, Yuan Yuan, Melos, Kendra I., Pirtskhalava, Tamar, Inman, Christina L., McGuckian, Collin, Wade, Erin A., Kato, Jonathon I., Grassi, Diego, Wentworth, Mark, Burd, Christin E., Arriaga, Edgar A., Ladiges, Warren L., Tchkonia, Tamara, Kirkland, James L., Robbins, Paul D., Niedernhofer, Laura J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Aging Animals Biological Products - pharmacology Biological Products - therapeutic use Biomarkers Cellular Senescence - drug effects Cellular Senescence - genetics Female Fibroblasts - drug effects Fibroblasts - metabolism Flavonoids - pharmacology Flavonoids - therapeutic use Flavonols Gene Expression Genes, Reporter Health Status Healthspan Humans Lifespan Lipid Peroxidation Longevity - drug effects Male Mice Mice, Knockout Progeria Research paper Senescence Senolytic
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