Combination of anthracyclines and anti-CD47 therapy inhibit invasive breast cancer growth while preventing cardiac toxicity by regulation of autophagy

Background A perennial challenge in systemic cytotoxic cancer therapy is to eradicate primary tumors and metastatic disease while sparing normal tissue from off-target effects of chemotherapy. Anthracyclines such as doxorubicin are effective chemotherapeutic agents for which dosing is limited by dev...

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Veröffentlicht in:	Breast cancer research and treatment 2018-11, Vol.172 (1), p.69-82
Hauptverfasser:	Feliz-Mosquea, Yismeilin R., Christensen, Ashley A., Wilson, Adam S., Westwood, Brian, Varagic, Jasmina, Meléndez, Giselle C., Schwartz, Anthony L., Chen, Qing-Rong, Mathews Griner, Lesley, Guha, Rajarshi, Thomas, Craig J., Ferrer, Marc, Merino, Maria J., Cook, Katherine L., Roberts, David D., Soto-Pantoja, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal experimentation Animals Anthracycline Anthracyclines Anthracyclines - pharmacology Apoptosis - drug effects Autophagy Autophagy - drug effects Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - pathology Cancer metastasis Cancer prevention Cancer research Cancer therapies Cardiotoxicity Cardiotoxicity - drug therapy Cardiotoxicity - genetics CD47 Antigen - antagonists & inhibitors CD47 Antigen - immunology Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell survival Chemotherapy Cytolysis Cytotoxicity Doxorubicin Female Growth Health aspects Heart Humans Immune response Innate immunity Invasiveness Ionizing radiation Macrophages MCF-7 Cells Medicine Medicine & Public Health Metastases Metastasis Mice Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Oncology Phagocytosis Preclinical Study Soft tissues Toxicity Tumor cell lines Tumors
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