Selective C-H halogenation over hydroxylation by non-heme iron(iv)-oxo

Non-heme iron based halogenase enzymes promote selective halogenation of the sp -C-H bond through iron(iv)-oxo-halide active species. During halogenation, competitive hydroxylation can be prevented completely in enzymatic systems. However, synthetic iron(iv)-oxo-halide intermediates often result in...

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Veröffentlicht in:	Chemical science (Cambridge) 2018-10, Vol.9 (40), p.7843-7858
Hauptverfasser:	Rana, Sujoy, Biswas, Jyoti Prasad, Sen, Asmita, Clémancey, Martin, Blondin, Geneviève, Latour, Jean-Marc, Rajaraman, Gopalan, Maiti, Debabrata
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Chemical Sciences Chemistry Coordination compounds Crystallography Electronic structure Enzymes Halogenation Hydrogen bonds Hydroxylation Iron Substrates
Online-Zugang:	Volltext
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