Glycyrrhizic acid activates chicken macrophages and enhances their Salmonella-killing capacity in vitro

Objective Salmonella enterica remains a major cause of food-borne disease in humans, and Salmonella Typhimurium (ST) contamination of poultry products is a worldwide problem. Since macrophages play an essential role in controlling Salmonella infection, the aim of this study was to evaluate the effec...

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Veröffentlicht in:	Journal of Zhejiang University. B. Science 2018-10, Vol.19 (10), p.785-795
Hauptverfasser:	Wang, Bai-kui, Mao, Yu-long, Gong, Li, Xu, Xin, Jiang, Shou-qun, Wang, Yi-bing, Li, Wei-fen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine c-Jun protein CD40 antigen CD80 antigen CD83 antigen Cell surface Cells, Cultured Chickens Contamination Cytokines Dextran Fluorescein Fluorescein isothiocyanate Food contamination Foodborne diseases Gene expression Glycyrrhizic Acid - pharmacology Hydrogen peroxide Immune response Interferon Interleukin 10 Interleukin 6 Internalization JNK protein Kinases Lipopolysaccharides Macrophage Activation - drug effects Macrophages NAD(P)H oxidase NF-kappa B - physiology NF-κB protein Nitric oxide Phagocytosis Phagocytosis - drug effects Poultry Ribonucleic acid RNA Salmonella Salmonella - drug effects Salmonella enterica Signal Transduction - drug effects Transcription factors Tumor necrosis factor-TNF γ-Interferon
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