Matured Hop-Derived Bitter Components in Beer Improve Hippocampus-Dependent Memory Through Activation of the Vagus Nerve
Improving and maintaining memory function is effective in preventing cognitive decline and dementia. Previously, we demonstrated that iso-α-acids, the hop-derived bitter components in beer, prevent cognitive impairment in an Alzheimer’s disease mouse model. In this report, we investigated the effect...
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| Veröffentlicht in: | Scientific reports 2018-10, Vol.8 (1), p.15372-10, Article 15372 |
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| creator | Ayabe, Tatsuhiro Ohya, Rena Taniguchi, Yoshimasa Shindo, Kazutoshi Kondo, Keiji Ano, Yasuhisa |
| description | Improving and maintaining memory function is effective in preventing cognitive decline and dementia. Previously, we demonstrated that iso-α-acids, the hop-derived bitter components in beer, prevent cognitive impairment in an Alzheimer’s disease mouse model. In this report, we investigated the effects of matured hop bitter acids (MHBA) containing components of oxides derived from α- and β-acids, and structurally similar to iso-α-acids, on cognitive function using behavioral pharmacological procedures. MHBA and the representative components of MHBA, 4′-hydroxyallohumulinone (HAH) and 4′-hydroxy-
cis
-alloisohumulone (HAIH) improved spatial working memory in scopolamine-induced amnesia mice. MHBA also enhanced episodic memory in the novel object recognition test (NORT). The administration of MHBA increased the amount of norepinephrine (NE) and NE release into cerebrospinal fluid (CSF) in hippocampus. The MHBA activity in improving memory function was attenuated by treatment with a β-adrenergic receptor inhibitor. In addition, vagotomized mice did not display the memory improvement induced by MHBA. Together, our results suggest that MHBA improves memory function via stimulation of the vagus nerve and enhancement of NE release in the hippocampus. Vagus nerve activation by the intake of food materials including MHBA may be a safe and effective approach for improving cognitive function. |
| doi_str_mv | 10.1038/s41598-018-33866-1 |
| format | Article |
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cis
-alloisohumulone (HAIH) improved spatial working memory in scopolamine-induced amnesia mice. MHBA also enhanced episodic memory in the novel object recognition test (NORT). The administration of MHBA increased the amount of norepinephrine (NE) and NE release into cerebrospinal fluid (CSF) in hippocampus. The MHBA activity in improving memory function was attenuated by treatment with a β-adrenergic receptor inhibitor. In addition, vagotomized mice did not display the memory improvement induced by MHBA. Together, our results suggest that MHBA improves memory function via stimulation of the vagus nerve and enhancement of NE release in the hippocampus. Vagus nerve activation by the intake of food materials including MHBA may be a safe and effective approach for improving cognitive function.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-33866-1</identifier><identifier>PMID: 30337611</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378/2649/2150 ; 64/60 ; 692/617/375/132/1283 ; Acids ; Acids - isolation & purification ; Acids - pharmacology ; Adrenergic receptors ; Alzheimer Disease - pathology ; Alzheimer Disease - physiopathology ; Alzheimer Disease - psychology ; Amnesia ; Animals ; Beer - analysis ; Behavior, Animal - drug effects ; Bitter acids ; Cerebrospinal fluid ; Cognition - drug effects ; Cognitive ability ; Cognitive Dysfunction - physiopathology ; Cognitive Dysfunction - prevention & control ; Dementia disorders ; Disease Models, Animal ; Food intake ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - physiology ; Humanities and Social Sciences ; Humulus - chemistry ; Humulus - physiology ; Male ; Memory ; Memory - drug effects ; Mice ; Mice, Inbred ICR ; multidisciplinary ; Norepinephrine ; Oxides ; Pattern recognition ; Science ; Science (multidisciplinary) ; Scopolamine ; Short term memory ; Spatial memory ; Spatial Memory - drug effects ; Taste ; Vagus nerve ; Vagus Nerve - drug effects</subject><ispartof>Scientific reports, 2018-10, Vol.8 (1), p.15372-10, Article 15372</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-6f36b1e8d0ab65dcf785e3751605afc3d325087f26424c9f3f44304cce99664a3</citedby><cites>FETCH-LOGICAL-c588t-6f36b1e8d0ab65dcf785e3751605afc3d325087f26424c9f3f44304cce99664a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194057/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194057/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,41099,42168,51555,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30337611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ayabe, Tatsuhiro</creatorcontrib><creatorcontrib>Ohya, Rena</creatorcontrib><creatorcontrib>Taniguchi, Yoshimasa</creatorcontrib><creatorcontrib>Shindo, Kazutoshi</creatorcontrib><creatorcontrib>Kondo, Keiji</creatorcontrib><creatorcontrib>Ano, Yasuhisa</creatorcontrib><title>Matured Hop-Derived Bitter Components in Beer Improve Hippocampus-Dependent Memory Through Activation of the Vagus Nerve</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Improving and maintaining memory function is effective in preventing cognitive decline and dementia. Previously, we demonstrated that iso-α-acids, the hop-derived bitter components in beer, prevent cognitive impairment in an Alzheimer’s disease mouse model. In this report, we investigated the effects of matured hop bitter acids (MHBA) containing components of oxides derived from α- and β-acids, and structurally similar to iso-α-acids, on cognitive function using behavioral pharmacological procedures. MHBA and the representative components of MHBA, 4′-hydroxyallohumulinone (HAH) and 4′-hydroxy-
cis
-alloisohumulone (HAIH) improved spatial working memory in scopolamine-induced amnesia mice. MHBA also enhanced episodic memory in the novel object recognition test (NORT). The administration of MHBA increased the amount of norepinephrine (NE) and NE release into cerebrospinal fluid (CSF) in hippocampus. The MHBA activity in improving memory function was attenuated by treatment with a β-adrenergic receptor inhibitor. In addition, vagotomized mice did not display the memory improvement induced by MHBA. Together, our results suggest that MHBA improves memory function via stimulation of the vagus nerve and enhancement of NE release in the hippocampus. Vagus nerve activation by the intake of food materials including MHBA may be a safe and effective approach for improving cognitive function.</description><subject>631/378/2649/2150</subject><subject>64/60</subject><subject>692/617/375/132/1283</subject><subject>Acids</subject><subject>Acids - isolation & purification</subject><subject>Acids - pharmacology</subject><subject>Adrenergic receptors</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer Disease - psychology</subject><subject>Amnesia</subject><subject>Animals</subject><subject>Beer - analysis</subject><subject>Behavior, Animal - drug effects</subject><subject>Bitter acids</subject><subject>Cerebrospinal fluid</subject><subject>Cognition - drug effects</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Cognitive Dysfunction - prevention & control</subject><subject>Dementia disorders</subject><subject>Disease Models, Animal</subject><subject>Food intake</subject><subject>Hippocampus</subject><subject>Hippocampus - 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isolation & purification</topic><topic>Acids - pharmacology</topic><topic>Adrenergic receptors</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer Disease - psychology</topic><topic>Amnesia</topic><topic>Animals</topic><topic>Beer - analysis</topic><topic>Behavior, Animal - drug effects</topic><topic>Bitter acids</topic><topic>Cerebrospinal fluid</topic><topic>Cognition - drug effects</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Cognitive Dysfunction - prevention & control</topic><topic>Dementia disorders</topic><topic>Disease Models, Animal</topic><topic>Food intake</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>Humanities and Social Sciences</topic><topic>Humulus - chemistry</topic><topic>Humulus - physiology</topic><topic>Male</topic><topic>Memory</topic><topic>Memory - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>multidisciplinary</topic><topic>Norepinephrine</topic><topic>Oxides</topic><topic>Pattern recognition</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Scopolamine</topic><topic>Short term memory</topic><topic>Spatial memory</topic><topic>Spatial Memory - drug effects</topic><topic>Taste</topic><topic>Vagus nerve</topic><topic>Vagus Nerve - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ayabe, Tatsuhiro</creatorcontrib><creatorcontrib>Ohya, Rena</creatorcontrib><creatorcontrib>Taniguchi, Yoshimasa</creatorcontrib><creatorcontrib>Shindo, Kazutoshi</creatorcontrib><creatorcontrib>Kondo, Keiji</creatorcontrib><creatorcontrib>Ano, Yasuhisa</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ayabe, Tatsuhiro</au><au>Ohya, Rena</au><au>Taniguchi, Yoshimasa</au><au>Shindo, Kazutoshi</au><au>Kondo, Keiji</au><au>Ano, Yasuhisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Matured Hop-Derived Bitter Components in Beer Improve Hippocampus-Dependent Memory Through Activation of the Vagus Nerve</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-10-18</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>15372</spage><epage>10</epage><pages>15372-10</pages><artnum>15372</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Improving and maintaining memory function is effective in preventing cognitive decline and dementia. Previously, we demonstrated that iso-α-acids, the hop-derived bitter components in beer, prevent cognitive impairment in an Alzheimer’s disease mouse model. In this report, we investigated the effects of matured hop bitter acids (MHBA) containing components of oxides derived from α- and β-acids, and structurally similar to iso-α-acids, on cognitive function using behavioral pharmacological procedures. MHBA and the representative components of MHBA, 4′-hydroxyallohumulinone (HAH) and 4′-hydroxy-
cis
-alloisohumulone (HAIH) improved spatial working memory in scopolamine-induced amnesia mice. MHBA also enhanced episodic memory in the novel object recognition test (NORT). The administration of MHBA increased the amount of norepinephrine (NE) and NE release into cerebrospinal fluid (CSF) in hippocampus. The MHBA activity in improving memory function was attenuated by treatment with a β-adrenergic receptor inhibitor. In addition, vagotomized mice did not display the memory improvement induced by MHBA. Together, our results suggest that MHBA improves memory function via stimulation of the vagus nerve and enhancement of NE release in the hippocampus. Vagus nerve activation by the intake of food materials including MHBA may be a safe and effective approach for improving cognitive function.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30337611</pmid><doi>10.1038/s41598-018-33866-1</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/378/2649/2150 64/60 692/617/375/132/1283 Acids Acids - isolation & purification Acids - pharmacology Adrenergic receptors Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer Disease - psychology Amnesia Animals Beer - analysis Behavior, Animal - drug effects Bitter acids Cerebrospinal fluid Cognition - drug effects Cognitive ability Cognitive Dysfunction - physiopathology Cognitive Dysfunction - prevention & control Dementia disorders Disease Models, Animal Food intake Hippocampus Hippocampus - drug effects Hippocampus - physiology Humanities and Social Sciences Humulus - chemistry Humulus - physiology Male Memory Memory - drug effects Mice Mice, Inbred ICR multidisciplinary Norepinephrine Oxides Pattern recognition Science Science (multidisciplinary) Scopolamine Short term memory Spatial memory Spatial Memory - drug effects Taste Vagus nerve Vagus Nerve - drug effects |
| title | Matured Hop-Derived Bitter Components in Beer Improve Hippocampus-Dependent Memory Through Activation of the Vagus Nerve |
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