P2X7 as a scavenger receptor for innate phagocytosis in the brain

The P2X7 receptor has been widely studied for its ATP‐induced pro‐inflammatory effect, but in the absence of a ligand, P2X7 has a second function as a scavenger receptor, which is active in the development of the human brain. The scavenger activity of P2X7 is only evident in the absence of serum but...

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Veröffentlicht in:	British journal of pharmacology 2018-11, Vol.175 (22), p.4195-4208
Hauptverfasser:	Gu, Ben J, Wiley, James S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Humans Phagocytosis Receptors, Purinergic P2X7 - metabolism Review
Online-Zugang:	Volltext
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