Selective Attention, Working Memory, and Executive Function as Potential Independent Sources of Cognitive Dysfunction in Schizophrenia
People with schizophrenia demonstrate impairments in selective attention, working memory, and executive function. Given the overlap in these constructs, it is unclear if these represent distinct impairments or different manifestations of one higher-order impairment. To examine this question, we admi...
Gespeichert in:
| Veröffentlicht in: | Schizophrenia bulletin 2018-10, Vol.44 (6), p.1227-1234 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1234 |
|---|---|
| container_issue | 6 |
| container_start_page | 1227 |
| container_title | Schizophrenia bulletin |
| container_volume | 44 |
| creator | Gold, James M Robinson, Benjamin Leonard, Carly J Hahn, Britta Chen, Shuo McMahon, Robert P Luck, Steven J |
| description | People with schizophrenia demonstrate impairments in selective attention, working memory, and executive function. Given the overlap in these constructs, it is unclear if these represent distinct impairments or different manifestations of one higher-order impairment. To examine this question, we administered tasks from the basic cognitive neuroscience literature to measure visual selective attention, working memory capacity, and executive function in 126 people with schizophrenia and 122 healthy volunteers. Patients demonstrated deficits on all tasks with the exception of selective attention guided by strong bottom-up inputs. Although the measures of top-down control of selective attention, working memory, and executive function were all intercorrelated, several sources of evidence indicate that working memory and executive function are separate sources of variance. Specifically, both working memory and executive function independently contributed to the discrimination of group status and independently accounted for variance in overall general cognitive ability as assessed by the MATRICS battery. These two cognitive functions appear to be separable features of the cognitive impairments observed in schizophrenia. |
| doi_str_mv | 10.1093/schbul/sbx155 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6192492</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1964707844</sourcerecordid><originalsourceid>FETCH-LOGICAL-c343t-968e84fee31298c0123a04a5e103ac3f14cbe1c73953d6d80d359305777ce85a3</originalsourceid><addsrcrecordid>eNpVkU9PGzEQxS3UCgLtsdfKxx7Y4lnb6_WlEgp_ikTVSmnVo-V4ZxO3GzvYu4jwAfjcLAmg9jJzmN9786RHyAdgn4FpfpLdcj50J3l-B1LukQkoIQtQDN6QCZN1VagKxAE5zPkPYyB0Ve6Tg1KDYJKJCXmYYYeu97dIT_seQ-9jOKa_Y_rrw4J-w1VMm2NqQ0PP79ANW_BiCO6JozbTH3Ersh29Cg2ucRyhp7M4JIeZxpZO4yL4rexsk9sXpQ905pb-Pq6XCYO378jb1nYZ3z_vI_Lr4vzn9Gtx_f3yanp6XTgueF_oqsZatIgcSl07BiW3TFiJwLh1vAXh5ghOcS15UzU1a7jUnEmllMNaWn5Evux818N8hY0bwybbmXXyK5s2Jlpv_r8EvzSLeGsq0KXQ5Wjw6dkgxZsBc29WPjvsOhswDtmAroRiqhZiRIsd6lLMOWH7-gaYeerO7Lozu-5G_uO_2V7pl7L4I0ZOmvU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1964707844</pqid></control><display><type>article</type><title>Selective Attention, Working Memory, and Executive Function as Potential Independent Sources of Cognitive Dysfunction in Schizophrenia</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Gold, James M ; Robinson, Benjamin ; Leonard, Carly J ; Hahn, Britta ; Chen, Shuo ; McMahon, Robert P ; Luck, Steven J</creator><creatorcontrib>Gold, James M ; Robinson, Benjamin ; Leonard, Carly J ; Hahn, Britta ; Chen, Shuo ; McMahon, Robert P ; Luck, Steven J</creatorcontrib><description>People with schizophrenia demonstrate impairments in selective attention, working memory, and executive function. Given the overlap in these constructs, it is unclear if these represent distinct impairments or different manifestations of one higher-order impairment. To examine this question, we administered tasks from the basic cognitive neuroscience literature to measure visual selective attention, working memory capacity, and executive function in 126 people with schizophrenia and 122 healthy volunteers. Patients demonstrated deficits on all tasks with the exception of selective attention guided by strong bottom-up inputs. Although the measures of top-down control of selective attention, working memory, and executive function were all intercorrelated, several sources of evidence indicate that working memory and executive function are separate sources of variance. Specifically, both working memory and executive function independently contributed to the discrimination of group status and independently accounted for variance in overall general cognitive ability as assessed by the MATRICS battery. These two cognitive functions appear to be separable features of the cognitive impairments observed in schizophrenia.</description><identifier>ISSN: 0586-7614</identifier><identifier>EISSN: 1745-1701</identifier><identifier>DOI: 10.1093/schbul/sbx155</identifier><identifier>PMID: 29140504</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adult ; Attention - physiology ; Cognitive Dysfunction - physiopathology ; Executive Function - physiology ; Female ; Humans ; Male ; Memory, Short-Term - physiology ; Middle Aged ; Psychomotor Performance - physiology ; Regular ; Schizophrenia - physiopathology</subject><ispartof>Schizophrenia bulletin, 2018-10, Vol.44 (6), p.1227-1234</ispartof><rights>The Author(s) 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c343t-968e84fee31298c0123a04a5e103ac3f14cbe1c73953d6d80d359305777ce85a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192492/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192492/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29140504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gold, James M</creatorcontrib><creatorcontrib>Robinson, Benjamin</creatorcontrib><creatorcontrib>Leonard, Carly J</creatorcontrib><creatorcontrib>Hahn, Britta</creatorcontrib><creatorcontrib>Chen, Shuo</creatorcontrib><creatorcontrib>McMahon, Robert P</creatorcontrib><creatorcontrib>Luck, Steven J</creatorcontrib><title>Selective Attention, Working Memory, and Executive Function as Potential Independent Sources of Cognitive Dysfunction in Schizophrenia</title><title>Schizophrenia bulletin</title><addtitle>Schizophr Bull</addtitle><description>People with schizophrenia demonstrate impairments in selective attention, working memory, and executive function. Given the overlap in these constructs, it is unclear if these represent distinct impairments or different manifestations of one higher-order impairment. To examine this question, we administered tasks from the basic cognitive neuroscience literature to measure visual selective attention, working memory capacity, and executive function in 126 people with schizophrenia and 122 healthy volunteers. Patients demonstrated deficits on all tasks with the exception of selective attention guided by strong bottom-up inputs. Although the measures of top-down control of selective attention, working memory, and executive function were all intercorrelated, several sources of evidence indicate that working memory and executive function are separate sources of variance. Specifically, both working memory and executive function independently contributed to the discrimination of group status and independently accounted for variance in overall general cognitive ability as assessed by the MATRICS battery. These two cognitive functions appear to be separable features of the cognitive impairments observed in schizophrenia.</description><subject>Adult</subject><subject>Attention - physiology</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Memory, Short-Term - physiology</subject><subject>Middle Aged</subject><subject>Psychomotor Performance - physiology</subject><subject>Regular</subject><subject>Schizophrenia - physiopathology</subject><issn>0586-7614</issn><issn>1745-1701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU9PGzEQxS3UCgLtsdfKxx7Y4lnb6_WlEgp_ikTVSmnVo-V4ZxO3GzvYu4jwAfjcLAmg9jJzmN9786RHyAdgn4FpfpLdcj50J3l-B1LukQkoIQtQDN6QCZN1VagKxAE5zPkPYyB0Ve6Tg1KDYJKJCXmYYYeu97dIT_seQ-9jOKa_Y_rrw4J-w1VMm2NqQ0PP79ANW_BiCO6JozbTH3Ersh29Cg2ucRyhp7M4JIeZxpZO4yL4rexsk9sXpQ905pb-Pq6XCYO378jb1nYZ3z_vI_Lr4vzn9Gtx_f3yanp6XTgueF_oqsZatIgcSl07BiW3TFiJwLh1vAXh5ghOcS15UzU1a7jUnEmllMNaWn5Evux818N8hY0bwybbmXXyK5s2Jlpv_r8EvzSLeGsq0KXQ5Wjw6dkgxZsBc29WPjvsOhswDtmAroRiqhZiRIsd6lLMOWH7-gaYeerO7Lozu-5G_uO_2V7pl7L4I0ZOmvU</recordid><startdate>20181017</startdate><enddate>20181017</enddate><creator>Gold, James M</creator><creator>Robinson, Benjamin</creator><creator>Leonard, Carly J</creator><creator>Hahn, Britta</creator><creator>Chen, Shuo</creator><creator>McMahon, Robert P</creator><creator>Luck, Steven J</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181017</creationdate><title>Selective Attention, Working Memory, and Executive Function as Potential Independent Sources of Cognitive Dysfunction in Schizophrenia</title><author>Gold, James M ; Robinson, Benjamin ; Leonard, Carly J ; Hahn, Britta ; Chen, Shuo ; McMahon, Robert P ; Luck, Steven J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-968e84fee31298c0123a04a5e103ac3f14cbe1c73953d6d80d359305777ce85a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Attention - physiology</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Executive Function - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Memory, Short-Term - physiology</topic><topic>Middle Aged</topic><topic>Psychomotor Performance - physiology</topic><topic>Regular</topic><topic>Schizophrenia - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gold, James M</creatorcontrib><creatorcontrib>Robinson, Benjamin</creatorcontrib><creatorcontrib>Leonard, Carly J</creatorcontrib><creatorcontrib>Hahn, Britta</creatorcontrib><creatorcontrib>Chen, Shuo</creatorcontrib><creatorcontrib>McMahon, Robert P</creatorcontrib><creatorcontrib>Luck, Steven J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gold, James M</au><au>Robinson, Benjamin</au><au>Leonard, Carly J</au><au>Hahn, Britta</au><au>Chen, Shuo</au><au>McMahon, Robert P</au><au>Luck, Steven J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective Attention, Working Memory, and Executive Function as Potential Independent Sources of Cognitive Dysfunction in Schizophrenia</atitle><jtitle>Schizophrenia bulletin</jtitle><addtitle>Schizophr Bull</addtitle><date>2018-10-17</date><risdate>2018</risdate><volume>44</volume><issue>6</issue><spage>1227</spage><epage>1234</epage><pages>1227-1234</pages><issn>0586-7614</issn><eissn>1745-1701</eissn><abstract>People with schizophrenia demonstrate impairments in selective attention, working memory, and executive function. Given the overlap in these constructs, it is unclear if these represent distinct impairments or different manifestations of one higher-order impairment. To examine this question, we administered tasks from the basic cognitive neuroscience literature to measure visual selective attention, working memory capacity, and executive function in 126 people with schizophrenia and 122 healthy volunteers. Patients demonstrated deficits on all tasks with the exception of selective attention guided by strong bottom-up inputs. Although the measures of top-down control of selective attention, working memory, and executive function were all intercorrelated, several sources of evidence indicate that working memory and executive function are separate sources of variance. Specifically, both working memory and executive function independently contributed to the discrimination of group status and independently accounted for variance in overall general cognitive ability as assessed by the MATRICS battery. These two cognitive functions appear to be separable features of the cognitive impairments observed in schizophrenia.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>29140504</pmid><doi>10.1093/schbul/sbx155</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0586-7614 |
| ispartof | Schizophrenia bulletin, 2018-10, Vol.44 (6), p.1227-1234 |
| issn | 0586-7614 1745-1701 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6192492 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Attention - physiology Cognitive Dysfunction - physiopathology Executive Function - physiology Female Humans Male Memory, Short-Term - physiology Middle Aged Psychomotor Performance - physiology Regular Schizophrenia - physiopathology |
| title | Selective Attention, Working Memory, and Executive Function as Potential Independent Sources of Cognitive Dysfunction in Schizophrenia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T07%3A11%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Selective%20Attention,%20Working%20Memory,%20and%20Executive%20Function%20as%20Potential%20Independent%20Sources%20of%20Cognitive%20Dysfunction%20in%20Schizophrenia&rft.jtitle=Schizophrenia%20bulletin&rft.au=Gold,%20James%20M&rft.date=2018-10-17&rft.volume=44&rft.issue=6&rft.spage=1227&rft.epage=1234&rft.pages=1227-1234&rft.issn=0586-7614&rft.eissn=1745-1701&rft_id=info:doi/10.1093/schbul/sbx155&rft_dat=%3Cproquest_pubme%3E1964707844%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1964707844&rft_id=info:pmid/29140504&rfr_iscdi=true |