Molecular Recognition of the Hybrid‐2 Human Telomeric G‐Quadruplex by Epiberberine: Insights into Conversion of Telomeric G‐Quadruplex Structures

Human telomeres can form DNA G‐quadruplex (G4), an attractive target for anticancer drugs. Human telomeric G4s bear inherent structure polymorphism, challenging for understanding specific recognition by ligands or proteins. Protoberberines are medicinal natural‐products known to stabilize telomeric...

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Veröffentlicht in:	Angewandte Chemie International Edition 2018-08, Vol.57 (34), p.10888-10893
Hauptverfasser:	Lin, Clement, Wu, Guanhui, Wang, Kaibo, Onel, Buket, Sakai, Saburo, Shao, Yong, Yang, Danzhou
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine anticancer drug targets Antineoplastic drugs Antitumor agents Base Sequence berberine Berberine - analogs & derivatives Berberine - metabolism Berberine - pharmacology Binding Binding Sites Circular Dichroism Deoxyribonucleic acid DNA Drug development Drugs, Chinese Herbal G-quadruplexes G-Quadruplexes - drug effects G4-drug complexes Gene polymorphism human telomeres Humans Intercalating Agents - chemistry NMR NMR spectroscopy Nuclear magnetic resonance Nucleic Acid Conformation Polymorphism Potassium Potassium - chemistry Proteins Proton Magnetic Resonance Spectroscopy Recognition Telomerase Telomere Telomeres
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