Serial circulating omega 3 polyunsaturated fatty acids and healthy ageing among older adults in the Cardiovascular Health Study: prospective cohort study
To determine the longitudinal association between serial biomarker measures of circulating omega 3 polyunsaturated fatty acid (n3-PUFA) levels and healthy ageing. Prospective cohort study. Four communities in the United States (Cardiovascular Health Study) from 1992 to 2015. 2622 adults with a mean...
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| Veröffentlicht in: | BMJ (Online) 2018-10, Vol.363, p.k4067-k4067 |
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| creator | Lai, Heidi Tm de Oliveira Otto, Marcia C Lemaitre, Rozenn N McKnight, Barbara Song, Xiaoling King, Irena B Chaves, Paulo Hm Odden, Michelle C Newman, Anne B Siscovick, David S Mozaffarian, Dariush |
| description | To determine the longitudinal association between serial biomarker measures of circulating omega 3 polyunsaturated fatty acid (n3-PUFA) levels and healthy ageing.
Prospective cohort study.
Four communities in the United States (Cardiovascular Health Study) from 1992 to 2015.
2622 adults with a mean (SD) age of 74.4 (4.8) and with successful healthy ageing at baseline in 1992-93.
Cumulative levels of plasma phospholipid n3-PUFAs were measured using gas chromatography in 1992-93, 1998-99, and 2005-06, expressed as percentage of total fatty acids, including α-linolenic acid from plants and eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid from seafoood.
Healthy ageing defined as survival without chronic diseases (ie, cardiovascular disease, cancer, lung disease, and severe chronic kidney disease), the absence of cognitive and physical dysfunction, or death from other causes not part of the healthy ageing outcome after age 65. Events were centrally adjudicated or determined from medical records and diagnostic tests.
Higher levels of long chain n3-PUFAs were associated with an 18% lower risk (95% confidence interval 7% to 28%) of unhealthy ageing per interquintile range after multivariable adjustments with time-varying exposure and covariates. Individually, higher eicosapentaenoic acid and docosapentaenoic acid (but not docosahexaenoic acid) levels were associated with a lower risk: 15% (6% to 23%) and 16% (6% to 25%), respectively. α-linolenic acid from plants was not noticeably associated with unhealthy ageing (hazard ratio 0.92, 95% confidence interval 0.83 to 1.02).
In older adults, a higher cumulative level of serially measured circulating n3-PUFAs from seafood (eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid), eicosapentaenoic acid, and docosapentaenoic acid (but not docosahexaenoic acid from seafood or α-linolenic acid from plants) was associated with a higher likelihood of healthy ageing. These findings support guidelines for increased dietary consumption of n3-PUFAs in older adults. |
| doi_str_mv | 10.1136/bmj.k4067 |
| format | Article |
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Prospective cohort study.
Four communities in the United States (Cardiovascular Health Study) from 1992 to 2015.
2622 adults with a mean (SD) age of 74.4 (4.8) and with successful healthy ageing at baseline in 1992-93.
Cumulative levels of plasma phospholipid n3-PUFAs were measured using gas chromatography in 1992-93, 1998-99, and 2005-06, expressed as percentage of total fatty acids, including α-linolenic acid from plants and eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid from seafoood.
Healthy ageing defined as survival without chronic diseases (ie, cardiovascular disease, cancer, lung disease, and severe chronic kidney disease), the absence of cognitive and physical dysfunction, or death from other causes not part of the healthy ageing outcome after age 65. Events were centrally adjudicated or determined from medical records and diagnostic tests.
Higher levels of long chain n3-PUFAs were associated with an 18% lower risk (95% confidence interval 7% to 28%) of unhealthy ageing per interquintile range after multivariable adjustments with time-varying exposure and covariates. Individually, higher eicosapentaenoic acid and docosapentaenoic acid (but not docosahexaenoic acid) levels were associated with a lower risk: 15% (6% to 23%) and 16% (6% to 25%), respectively. α-linolenic acid from plants was not noticeably associated with unhealthy ageing (hazard ratio 0.92, 95% confidence interval 0.83 to 1.02).
In older adults, a higher cumulative level of serially measured circulating n3-PUFAs from seafood (eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid), eicosapentaenoic acid, and docosapentaenoic acid (but not docosahexaenoic acid from seafood or α-linolenic acid from plants) was associated with a higher likelihood of healthy ageing. These findings support guidelines for increased dietary consumption of n3-PUFAs in older adults.</description><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1756-1833</identifier><identifier>DOI: 10.1136/bmj.k4067</identifier><identifier>PMID: 30333104</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Aged ; Aging ; Cancer ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cognitive ability ; Cohort analysis ; Cohort Studies ; Docosahexaenoic acid ; Eicosapentaenoic acid ; Fatty Acids, Omega-3 - blood ; Female ; Gas chromatography ; Health risk assessment ; Health Services for the Aged ; Humans ; Linolenic acid ; Lung cancer ; Lung diseases ; Male ; Medical records ; Older people ; Phospholipids ; Polyunsaturated fatty acids ; Prospective Studies ; Seafood ; Socioeconomic Factors ; United States - epidemiology</subject><ispartof>BMJ (Online), 2018-10, Vol.363, p.k4067-k4067</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2018 BMJ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to 2018 BMJ</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-af26e60a67d6262c4a034941a1cecdd2df90165878b4f6d1322a46586030e2c63</citedby><cites>FETCH-LOGICAL-c403t-af26e60a67d6262c4a034941a1cecdd2df90165878b4f6d1322a46586030e2c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30333104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lai, Heidi Tm</creatorcontrib><creatorcontrib>de Oliveira Otto, Marcia C</creatorcontrib><creatorcontrib>Lemaitre, Rozenn N</creatorcontrib><creatorcontrib>McKnight, Barbara</creatorcontrib><creatorcontrib>Song, Xiaoling</creatorcontrib><creatorcontrib>King, Irena B</creatorcontrib><creatorcontrib>Chaves, Paulo Hm</creatorcontrib><creatorcontrib>Odden, Michelle C</creatorcontrib><creatorcontrib>Newman, Anne B</creatorcontrib><creatorcontrib>Siscovick, David S</creatorcontrib><creatorcontrib>Mozaffarian, Dariush</creatorcontrib><title>Serial circulating omega 3 polyunsaturated fatty acids and healthy ageing among older adults in the Cardiovascular Health Study: prospective cohort study</title><title>BMJ (Online)</title><addtitle>BMJ</addtitle><description>To determine the longitudinal association between serial biomarker measures of circulating omega 3 polyunsaturated fatty acid (n3-PUFA) levels and healthy ageing.
Prospective cohort study.
Four communities in the United States (Cardiovascular Health Study) from 1992 to 2015.
2622 adults with a mean (SD) age of 74.4 (4.8) and with successful healthy ageing at baseline in 1992-93.
Cumulative levels of plasma phospholipid n3-PUFAs were measured using gas chromatography in 1992-93, 1998-99, and 2005-06, expressed as percentage of total fatty acids, including α-linolenic acid from plants and eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid from seafoood.
Healthy ageing defined as survival without chronic diseases (ie, cardiovascular disease, cancer, lung disease, and severe chronic kidney disease), the absence of cognitive and physical dysfunction, or death from other causes not part of the healthy ageing outcome after age 65. Events were centrally adjudicated or determined from medical records and diagnostic tests.
Higher levels of long chain n3-PUFAs were associated with an 18% lower risk (95% confidence interval 7% to 28%) of unhealthy ageing per interquintile range after multivariable adjustments with time-varying exposure and covariates. Individually, higher eicosapentaenoic acid and docosapentaenoic acid (but not docosahexaenoic acid) levels were associated with a lower risk: 15% (6% to 23%) and 16% (6% to 25%), respectively. α-linolenic acid from plants was not noticeably associated with unhealthy ageing (hazard ratio 0.92, 95% confidence interval 0.83 to 1.02).
In older adults, a higher cumulative level of serially measured circulating n3-PUFAs from seafood (eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid), eicosapentaenoic acid, and docosapentaenoic acid (but not docosahexaenoic acid from seafood or α-linolenic acid from plants) was associated with a higher likelihood of healthy ageing. These findings support guidelines for increased dietary consumption of n3-PUFAs in older adults.</description><subject>Aged</subject><subject>Aging</subject><subject>Cancer</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cognitive ability</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Docosahexaenoic acid</subject><subject>Eicosapentaenoic acid</subject><subject>Fatty Acids, Omega-3 - blood</subject><subject>Female</subject><subject>Gas chromatography</subject><subject>Health risk assessment</subject><subject>Health Services for the Aged</subject><subject>Humans</subject><subject>Linolenic acid</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medical records</subject><subject>Older people</subject><subject>Phospholipids</subject><subject>Polyunsaturated fatty acids</subject><subject>Prospective Studies</subject><subject>Seafood</subject><subject>Socioeconomic Factors</subject><subject>United States - 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blood</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cognitive ability</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Docosahexaenoic acid</topic><topic>Eicosapentaenoic acid</topic><topic>Fatty Acids, Omega-3 - blood</topic><topic>Female</topic><topic>Gas chromatography</topic><topic>Health risk assessment</topic><topic>Health Services for the Aged</topic><topic>Humans</topic><topic>Linolenic acid</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Medical records</topic><topic>Older people</topic><topic>Phospholipids</topic><topic>Polyunsaturated fatty acids</topic><topic>Prospective Studies</topic><topic>Seafood</topic><topic>Socioeconomic Factors</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lai, Heidi Tm</creatorcontrib><creatorcontrib>de Oliveira Otto, Marcia C</creatorcontrib><creatorcontrib>Lemaitre, Rozenn N</creatorcontrib><creatorcontrib>McKnight, Barbara</creatorcontrib><creatorcontrib>Song, Xiaoling</creatorcontrib><creatorcontrib>King, Irena B</creatorcontrib><creatorcontrib>Chaves, Paulo Hm</creatorcontrib><creatorcontrib>Odden, Michelle C</creatorcontrib><creatorcontrib>Newman, Anne B</creatorcontrib><creatorcontrib>Siscovick, David S</creatorcontrib><creatorcontrib>Mozaffarian, Dariush</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ (Online)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lai, Heidi Tm</au><au>de Oliveira Otto, Marcia C</au><au>Lemaitre, Rozenn N</au><au>McKnight, Barbara</au><au>Song, Xiaoling</au><au>King, Irena B</au><au>Chaves, Paulo Hm</au><au>Odden, Michelle C</au><au>Newman, Anne B</au><au>Siscovick, David S</au><au>Mozaffarian, Dariush</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serial circulating omega 3 polyunsaturated fatty acids and healthy ageing among older adults in the Cardiovascular Health Study: prospective cohort study</atitle><jtitle>BMJ (Online)</jtitle><addtitle>BMJ</addtitle><date>2018-10-17</date><risdate>2018</risdate><volume>363</volume><spage>k4067</spage><epage>k4067</epage><pages>k4067-k4067</pages><issn>0959-8138</issn><eissn>1756-1833</eissn><abstract>To determine the longitudinal association between serial biomarker measures of circulating omega 3 polyunsaturated fatty acid (n3-PUFA) levels and healthy ageing.
Prospective cohort study.
Four communities in the United States (Cardiovascular Health Study) from 1992 to 2015.
2622 adults with a mean (SD) age of 74.4 (4.8) and with successful healthy ageing at baseline in 1992-93.
Cumulative levels of plasma phospholipid n3-PUFAs were measured using gas chromatography in 1992-93, 1998-99, and 2005-06, expressed as percentage of total fatty acids, including α-linolenic acid from plants and eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid from seafoood.
Healthy ageing defined as survival without chronic diseases (ie, cardiovascular disease, cancer, lung disease, and severe chronic kidney disease), the absence of cognitive and physical dysfunction, or death from other causes not part of the healthy ageing outcome after age 65. Events were centrally adjudicated or determined from medical records and diagnostic tests.
Higher levels of long chain n3-PUFAs were associated with an 18% lower risk (95% confidence interval 7% to 28%) of unhealthy ageing per interquintile range after multivariable adjustments with time-varying exposure and covariates. Individually, higher eicosapentaenoic acid and docosapentaenoic acid (but not docosahexaenoic acid) levels were associated with a lower risk: 15% (6% to 23%) and 16% (6% to 25%), respectively. α-linolenic acid from plants was not noticeably associated with unhealthy ageing (hazard ratio 0.92, 95% confidence interval 0.83 to 1.02).
In older adults, a higher cumulative level of serially measured circulating n3-PUFAs from seafood (eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid), eicosapentaenoic acid, and docosapentaenoic acid (but not docosahexaenoic acid from seafood or α-linolenic acid from plants) was associated with a higher likelihood of healthy ageing. These findings support guidelines for increased dietary consumption of n3-PUFAs in older adults.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>30333104</pmid><doi>10.1136/bmj.k4067</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | BMJ (Online), 2018-10, Vol.363, p.k4067-k4067 |
| issn | 0959-8138 1756-1833 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Aged Aging Cancer Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cognitive ability Cohort analysis Cohort Studies Docosahexaenoic acid Eicosapentaenoic acid Fatty Acids, Omega-3 - blood Female Gas chromatography Health risk assessment Health Services for the Aged Humans Linolenic acid Lung cancer Lung diseases Male Medical records Older people Phospholipids Polyunsaturated fatty acids Prospective Studies Seafood Socioeconomic Factors United States - epidemiology |
| title | Serial circulating omega 3 polyunsaturated fatty acids and healthy ageing among older adults in the Cardiovascular Health Study: prospective cohort study |
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