Quantitative diffuse reflectance spectroscopy of short-term changes in tumor oxygenation after radiation in a matched model of radiation resistance

Quantitative diffuse reflectance spectroscopy of short-term changes in tumor oxygenation after radiation in a matched model of radiation resistance

There is a critical need to identify patients with radiation-resistant tumors early after treatment commencement. In this study, we use diffuse reflectance spectroscopy (DRS) to investigate changes in vascular oxygenation and total hemoglobin concentration in A549 radiation-sensitive and resistant t...

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Veröffentlicht in:Biomedical optics express 2018-08, Vol.9 (8), p.3794-3804
Hauptverfasser: Diaz, Paola Monterroso, Jenkins, Samir V, Alhallak, Kinan, Semeniak, Daria, Griffin, Robert J, Dings, Ruud P M, Rajaram, Narasimhan
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container_end_page 3804
container_issue 8
container_start_page 3794
container_title Biomedical optics express
container_volume 9
creator Diaz, Paola Monterroso
Jenkins, Samir V
Alhallak, Kinan
Semeniak, Daria
Griffin, Robert J
Dings, Ruud P M
Rajaram, Narasimhan
description There is a critical need to identify patients with radiation-resistant tumors early after treatment commencement. In this study, we use diffuse reflectance spectroscopy (DRS) to investigate changes in vascular oxygenation and total hemoglobin concentration in A549 radiation-sensitive and resistant tumors treated with a clinically relevant dose fraction of 2 Gy. DRS spectra were acquired before, immediately after, 24, and 48 hours after radiation. Our data reveals a significantly higher reoxygenation (sO ) in the radiation-resistant tumors 24 and 48h after treatment, and provides promising evidence that DRS can discern between the reoxygenation trends of radiation-sensitive and resistant tumors.
doi_str_mv 10.1364/BOE.9.003794
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title Quantitative diffuse reflectance spectroscopy of short-term changes in tumor oxygenation after radiation in a matched model of radiation resistance
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