The Successful Treatment of Metastatic Extraosseous Ewing Sarcoma with Pazopanib
The clinical efficacy and outcomes of pazopanib treatment for metastatic extraosseous Ewing sarcoma remain unclear. We herein report a case of heavily pre-treated metastatic extraosseous Ewing sarcoma in which pazopanib treatment achieved a significant improvement. A 17-year-old girl was referred to...
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| Veröffentlicht in: | Internal Medicine 2018/09/15, Vol.57(18), pp.2753-2757 |
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| container_title | Internal Medicine |
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| creator | Mori, Yoshinori Kinoshita, Shiori Kanamori, Takashi Kataoka, Hiromi Joh, Takashi Iida, Shinsuke Takemoto, Masashi Kondo, Masahiro Kuroda, Junko Komatsu, Hirokazu |
| description | The clinical efficacy and outcomes of pazopanib treatment for metastatic extraosseous Ewing sarcoma remain unclear. We herein report a case of heavily pre-treated metastatic extraosseous Ewing sarcoma in which pazopanib treatment achieved a significant improvement. A 17-year-old girl was referred to our hospital due to metastatic extraosseous Ewing sarcoma. The initial cytotoxic chemotherapy was temporarily effective, however, her disease eventually progressed, and she was subsequently treated with pazopanib. The recurrent tumor showed a marked response to pazopanib therapy; the therapeutic effect has lasted for more than 26 months. The present case suggests that pazopanib may be a therapeutic option for extraosseous Ewing sarcoma. |
| doi_str_mv | 10.2169/internalmedicine.9879-17 |
| format | Article |
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Med.</addtitle><description>The clinical efficacy and outcomes of pazopanib treatment for metastatic extraosseous Ewing sarcoma remain unclear. We herein report a case of heavily pre-treated metastatic extraosseous Ewing sarcoma in which pazopanib treatment achieved a significant improvement. A 17-year-old girl was referred to our hospital due to metastatic extraosseous Ewing sarcoma. The initial cytotoxic chemotherapy was temporarily effective, however, her disease eventually progressed, and she was subsequently treated with pazopanib. The recurrent tumor showed a marked response to pazopanib therapy; the therapeutic effect has lasted for more than 26 months. The present case suggests that pazopanib may be a therapeutic option for extraosseous Ewing sarcoma.</description><subject>Case Report</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Cytotoxicity</subject><subject>Ewing's sarcoma</subject><subject>extraosseous Ewing sarcoma</subject><subject>Internal medicine</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>pazopanib</subject><subject>Sarcoma</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNplkVtvEzEQhS0EoqHwF5AlXnjZ4ste7BckVIWCVNRKDc_WrDObONr1BtvbAr--XiVEUCRr_OBvjmfOIYRydiF4rT84nzB46AdcO-s8XmjV6II3z8iCy1IXjZDVc7JgmqtC5HJGXsW4Y0xmTLwkZ0I3ivGqXpDb1Rbp3WQtxthNPV0FhDSgT3Ts6DdMEBMkZ-nyZwowxojjFOnywfkNvYNgxwHog0tbegu_xz14174mLzroI7453ufk--fl6vJLcX1z9fXy03Vha85S0UJdAQpYd21ZW1mqte1QQcVAVIyDxU6VouW86zi2-bTIWSUb5FJLhVzLc_LxoLuf2myDzSMH6M0-uAHCLzOCM_--eLc1m_He1FzzSsss8P4oEMYfE8ZkBhct9j34eUkjWCmErIVUGX33BN2N0-x_pkRZ6-x5OU-kDpQN2aiA3WkYzswcm3kam5ljM7zJrW__XubU-CenDNwcgF3OY4MnAEIOp8f_lavGcDXX4xcn0m4hGPTyEaAhuNU</recordid><startdate>20180915</startdate><enddate>20180915</enddate><creator>Mori, Yoshinori</creator><creator>Kinoshita, Shiori</creator><creator>Kanamori, Takashi</creator><creator>Kataoka, Hiromi</creator><creator>Joh, Takashi</creator><creator>Iida, Shinsuke</creator><creator>Takemoto, Masashi</creator><creator>Kondo, Masahiro</creator><creator>Kuroda, Junko</creator><creator>Komatsu, Hirokazu</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180915</creationdate><title>The Successful Treatment of Metastatic Extraosseous Ewing Sarcoma with Pazopanib</title><author>Mori, Yoshinori ; Kinoshita, Shiori ; Kanamori, Takashi ; Kataoka, Hiromi ; Joh, Takashi ; Iida, Shinsuke ; Takemoto, Masashi ; Kondo, Masahiro ; Kuroda, Junko ; Komatsu, Hirokazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-ba65ae2adfb46c348dcfe8a50a2501acef842b11ff1eb1ebbe10537e13938e193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Case Report</topic><topic>Case reports</topic><topic>Chemotherapy</topic><topic>Cytotoxicity</topic><topic>Ewing's sarcoma</topic><topic>extraosseous Ewing sarcoma</topic><topic>Internal medicine</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>pazopanib</topic><topic>Sarcoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mori, Yoshinori</creatorcontrib><creatorcontrib>Kinoshita, Shiori</creatorcontrib><creatorcontrib>Kanamori, Takashi</creatorcontrib><creatorcontrib>Kataoka, Hiromi</creatorcontrib><creatorcontrib>Joh, Takashi</creatorcontrib><creatorcontrib>Iida, Shinsuke</creatorcontrib><creatorcontrib>Takemoto, Masashi</creatorcontrib><creatorcontrib>Kondo, Masahiro</creatorcontrib><creatorcontrib>Kuroda, Junko</creatorcontrib><creatorcontrib>Komatsu, Hirokazu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mori, Yoshinori</au><au>Kinoshita, Shiori</au><au>Kanamori, Takashi</au><au>Kataoka, Hiromi</au><au>Joh, Takashi</au><au>Iida, Shinsuke</au><au>Takemoto, Masashi</au><au>Kondo, Masahiro</au><au>Kuroda, Junko</au><au>Komatsu, Hirokazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Successful Treatment of Metastatic Extraosseous Ewing Sarcoma with Pazopanib</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2018-09-15</date><risdate>2018</risdate><volume>57</volume><issue>18</issue><spage>2753</spage><epage>2757</epage><pages>2753-2757</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>The clinical efficacy and outcomes of pazopanib treatment for metastatic extraosseous Ewing sarcoma remain unclear. We herein report a case of heavily pre-treated metastatic extraosseous Ewing sarcoma in which pazopanib treatment achieved a significant improvement. A 17-year-old girl was referred to our hospital due to metastatic extraosseous Ewing sarcoma. The initial cytotoxic chemotherapy was temporarily effective, however, her disease eventually progressed, and she was subsequently treated with pazopanib. The recurrent tumor showed a marked response to pazopanib therapy; the therapeutic effect has lasted for more than 26 months. 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| source | J-STAGE Free; PubMed Central Open Access; PubMed Central |
| subjects | Case Report Case reports Chemotherapy Cytotoxicity Ewing's sarcoma extraosseous Ewing sarcoma Internal medicine Metastases Metastasis pazopanib Sarcoma |
| title | The Successful Treatment of Metastatic Extraosseous Ewing Sarcoma with Pazopanib |
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