Maternal smoke exposure decreases mesenchymal proliferation and modulates Rho‐GTPase‐dependent actin cytoskeletal signaling in fetal lungs

ABSTRACT The present study tested the hypothesis that maternal smoke exposure results in fetal lung growth retardation due to dysregulation in various signaling pathways, including the Wnt (wingless‐related integration site)/β‐catenin pathway. Pregnant female C57BL/6J mice were exposed to cigarette...

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Veröffentlicht in:	The FASEB journal 2017-06, Vol.31 (6), p.2340-2351
Hauptverfasser:	Unachukwu, Uchenna, Trischler, Jordis, Goldklang, Monica, Xiao, Rui, D'Armiento, Jeanine
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - physiology Animals Apoptosis Body weight Caspase Cell proliferation Cell Proliferation - drug effects Cigarette smoke Cyclin D1 Cytoskeleton Embryos Epithelium Exposure Female Fetus - drug effects Fetuses Frizzled protein Frizzled-related protein Frizzled-related protein 1 Gene expression Gene Expression Regulation, Developmental - drug effects Gene sequencing Gene therapy Genomes Growth rate GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism Guanine nucleotide-binding protein Guanosine triphosphatases in utero Lung - drug effects Lung - embryology Lung - metabolism Lungs Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - physiology Mesenchyme Mice Nucleotide sequence Offspring Pregnancy proliferation Ribonucleic acid RNA Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Signaling Smoke Smoke - adverse effects Stereology Tobacco Products Wnt Proteins - genetics Wnt Proteins - metabolism Wnt/β‐catenin
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