Assessment of Pain Sensitivity in Patients With Chronic Low Back Pain and Association With HTR2A Gene Polymorphism

Assessment of Pain Sensitivity in Patients With Chronic Low Back Pain and Association With HTR2A Gene Polymorphism

This study aims to investigate the association of two common HTR2A gene polymorphisms, rs6313 (102 T/C) and rs6311 (1438 A/G), with chronic low back pain (CLBP) and the pain threshold, disability, and sex differences. A total of 121 patients (40 males, 81 females; mean age 36.8±9.9 years; range 18 t...

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Veröffentlicht in:Archives of rheumatology 2017-03, Vol.32 (1), p.3-9
Hauptverfasser: Yildiz, Saliha Handan, Ulaşli, Alper Murat, Özdemir Erdoğan, Müjgan, Dikici, Ömer, Arikan Terzi, Evrim Suna, Dündar, Ümit, Solak, Mustafa
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Backache
Care and treatment
Genes
Genetic aspects
Genetic research
Single nucleotide polymorphisms
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container_title Archives of rheumatology
container_volume 32
creator Yildiz, Saliha Handan
Ulaşli, Alper Murat
Özdemir Erdoğan, Müjgan
Dikici, Ömer
Arikan Terzi, Evrim Suna
Dündar, Ümit
Solak, Mustafa
description This study aims to investigate the association of two common HTR2A gene polymorphisms, rs6313 (102 T/C) and rs6311 (1438 A/G), with chronic low back pain (CLBP) and the pain threshold, disability, and sex differences. A total of 121 patients (40 males, 81 females; mean age 36.8±9.9 years; range 18 to 50 years) having CLBP and 91 healthy controls (26 males, 65 females; mean age 34.1±10.2 years; range 18 to 55 years) were included. Pressure pain thresholds (PPTs) of all participants were examined with manual algometer in certain sites of their body. The PPTs were all decreased in CLBP patients (p0.05). rs6311 polymorphism of HTR2A gene was associated with CLBP (p
doi_str_mv 10.5606/ArchRheumatol.2017.5846
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A total of 121 patients (40 males, 81 females; mean age 36.8±9.9 years; range 18 to 50 years) having CLBP and 91 healthy controls (26 males, 65 females; mean age 34.1±10.2 years; range 18 to 55 years) were included. Pressure pain thresholds (PPTs) of all participants were examined with manual algometer in certain sites of their body. The PPTs were all decreased in CLBP patients (p&lt;0.05). Although PPTs were lower in healthy female subjects, there was no sex difference regarding PPTs in CLBP patients (p&gt;0.05). rs6311 polymorphism of HTR2A gene was associated with CLBP (p&lt;0.05). In rs6313 polymorphism, at least one copy of T carriers and in rs6311 polymorphism, at least one copy of G carriers showed higher disability. The PPT decreases in CLBP patients similar to other chronic pain conditions without any sex difference. 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subjects Backache
Care and treatment
Genes
Genetic aspects
Genetic research
Single nucleotide polymorphisms
title Assessment of Pain Sensitivity in Patients With Chronic Low Back Pain and Association With HTR2A Gene Polymorphism
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