The Human Cytomegalovirus Trimer and Pentamer Promote Sequential Steps in Entry into Epithelial and Endothelial Cells at Cell Surfaces and Endosomes

Human cytomegalovirus (HCMV) infects a wide variety of human cell types by different entry pathways that involve distinct envelope glycoprotein complexes that include gH/gL, a trimer complex consisting of gHgL/gO, and a pentamer complex consisting of gH/gL/UL128/UL130/UL131. We characterized the eff...

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Veröffentlicht in:	Journal of virology 2018-11, Vol.92 (21)
Hauptverfasser:	Liu, Jing, Jardetzky, Ted S, Chin, Andrea L, Johnson, David C, Vanarsdall, Adam L
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Membrane - virology Cells, Cultured Cytomegalovirus - genetics Cytomegalovirus - physiology Cytomegalovirus Infections - pathology DNA, Viral - metabolism Endosomes - virology Epithelial Cells - virology Human Umbilical Vein Endothelial Cells - virology Humans Membrane Glycoproteins - metabolism Protein Binding - physiology Protein Multimerization - physiology Retinal Pigment Epithelium - cytology Viral Envelope Proteins - metabolism Virus Internalization Virus-Cell Interactions
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