Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor

The relaxin-3 neuropeptide activates the relaxin family peptide 3 (RXFP3) receptor to modulate stress, appetite, and cognition. RXFP3 shows promise as a target for treating neurological disorders, but realization of its clinical potential requires development of smaller RXFP3-specific drugs that can...

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Veröffentlicht in:	The Journal of biological chemistry 2018-10, Vol.293 (41), p.15777-15789
Hauptverfasser:	Wong, Lilian L.L., Scott, Daniel James, Hossain, Mohammed Akhter, Kaas, Quentin, Rosengren, K. Johan, Bathgate, Ross A.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites G protein-coupled receptor (GPCR) HEK293 Cells Humans molecular docking Molecular Docking Simulation molecular modeling Mutagenesis, Site-Directed Peptides - chemical synthesis Peptides - chemistry Peptides - metabolism Protein Binding Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism relaxin Relaxin - chemical synthesis Relaxin - chemistry Relaxin - metabolism relaxin-3 RXFP3 Signal Transduction site-directed mutagenesis Static Electricity
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