Low‐molecular‐mass hyaluronan induces pulmonary inflammation by up‐regulation of Mcl‐1 to inhibit neutrophil apoptosis via PI3K/Akt1 pathway

Summary Although low‐molecular‐mass hyaluronan (LMMHA) has been implicated in pulmonary inflammatory diseases, the signalling pathway of LMMHA (200 000 molecular weight) that initiates the inflammatory response in lung is still unknown. In this study, we evaluate the role of phosphoinositide 3‐kinas...

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Veröffentlicht in:	Immunology 2018-11, Vol.155 (3), p.387-395
Hauptverfasser:	Zhao, Hang, Ma, Yating, Zhang, Leifang
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT1 protein Alveoli Animals Apoptosis Apoptosis - drug effects Apoptosis - genetics Apoptosis - immunology Bronchus Caspase Cell activation Cell differentiation Clonal deletion Differentiation (biology) Hyaluronic acid Hyaluronic Acid - pharmacology Hyaluronic Acid - toxicity Inflammation Inflammation - chemically induced Inflammation - genetics Inflammation - immunology Inflammation - pathology Inflammatory diseases Inflammatory response Interleukins Kinases Leukemia low‐molecular‐weight hyaluronan (200 000 MW) Lung - immunology Lung - pathology Lung diseases lung inflammation Lungs Matrix metalloproteinase Mcl‐1 Medical treatment Metalloproteinase Mice Mice, Knockout Molecular weight Myeloid Cell Leukemia Sequence 1 Protein - genetics Myeloid Cell Leukemia Sequence 1 Protein - immunology neutrophil Neutrophils Neutrophils - immunology Neutrophils - pathology Original Pharmacology Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - immunology phosphoinositide 3‐kinase/Akt1 Pneumonia - chemically induced Pneumonia - genetics Pneumonia - immunology Pneumonia - pathology Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - immunology Signal transduction Signal Transduction - drug effects Signal Transduction - genetics Signal Transduction - immunology Signaling Trachea Up-Regulation - drug effects Up-Regulation - immunology
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