The Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats
Benign prostatic hyperplasia (BPH) is common among elderly men, of which inflammation, oxidative stress, proliferative, and apoptotic changes play important roles. Xialiqi (XLQ) capsule, a traditional Chinese herbal formula, is used as a potential drug in treating BPH. This study aims to evaluate th...
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| creator | Shang, Xuejun Yan, Zechen Zhang, Guowei Cai, Hongcai |
| description | Benign prostatic hyperplasia (BPH) is common among elderly men, of which inflammation, oxidative stress, proliferative, and apoptotic changes play important roles. Xialiqi (XLQ) capsule, a traditional Chinese herbal formula, is used as a potential drug in treating BPH. This study aims to evaluate the therapeutic effect of XLQ capsule on testosterone propionate- (TP-) induced BPH in rats. Fifty male Sprague-Dawley rats were randomly divided into 5 groups: sham control, BPH model, high and low dose of XLQ, and finasteride as a positive control group. All groups were treated with appropriate drugs/normal saline for 28 consecutive days. Prostate weights were recorded; histopathological changes and content of IL-8, TNF-α, DHT, SOD, MDA, caspase-3, and PCNA of the prostate were determined. Animals with BPH demonstrated significantly increased prostate weights and prostate index, higher levels of IL-8, TNF-α, DHT, MDA, and PCNA, but lower activity of SOD and reduced expression of caspase-3. After treatment with XLQ, significant reductions of prostate weights, prostate index, IL-8, TNF-α, DHT, MDA, and PCNA, increased activity of SOD, and higher level of caspase-3 were shown. The present study indicates that XLQ can effectively prevent the development of TP-induced BPH model through mechanisms of anti-inflammation, antioxidation, antiproliferation, and proapoptosis. |
| doi_str_mv | 10.1155/2018/5367814 |
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Xialiqi (XLQ) capsule, a traditional Chinese herbal formula, is used as a potential drug in treating BPH. This study aims to evaluate the therapeutic effect of XLQ capsule on testosterone propionate- (TP-) induced BPH in rats. Fifty male Sprague-Dawley rats were randomly divided into 5 groups: sham control, BPH model, high and low dose of XLQ, and finasteride as a positive control group. All groups were treated with appropriate drugs/normal saline for 28 consecutive days. Prostate weights were recorded; histopathological changes and content of IL-8, TNF-α, DHT, SOD, MDA, caspase-3, and PCNA of the prostate were determined. Animals with BPH demonstrated significantly increased prostate weights and prostate index, higher levels of IL-8, TNF-α, DHT, MDA, and PCNA, but lower activity of SOD and reduced expression of caspase-3. After treatment with XLQ, significant reductions of prostate weights, prostate index, IL-8, TNF-α, DHT, MDA, and PCNA, increased activity of SOD, and higher level of caspase-3 were shown. The present study indicates that XLQ can effectively prevent the development of TP-induced BPH model through mechanisms of anti-inflammation, antioxidation, antiproliferation, and proapoptosis.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2018/5367814</identifier><identifier>PMID: 30364022</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Apoptosis ; Benign ; Cancer therapies ; Caspase ; Caspase-3 ; Cell growth ; Drug dosages ; Dutasteride ; Finasteride ; Genital diseases ; Geriatrics ; Health aspects ; Herbal medicine ; Hyperplasia ; Hypertrophy ; Inflammation ; Interleukin 8 ; Laboratory animals ; Medical research ; Medicine ; Medicine, Botanic ; Medicine, Herbal ; Older people ; Oxidative stress ; Pharmaceuticals ; Proliferating cell nuclear antigen ; Propionic acid ; Prostate ; Rats ; Rodents ; Testosterone ; Testosterone propionate ; Tumor necrosis factor-α ; Urology</subject><ispartof>Evidence-based complementary and alternative medicine, 2018-01, Vol.2018 (2018), p.1-9</ispartof><rights>Copyright © 2018 Hongcai Cai et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Hongcai Cai et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Hongcai Cai et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-46fe1f08082b65cabf73404383d9e2b17c9f068589c9b3ad661558b4e3433f033</citedby><cites>FETCH-LOGICAL-c499t-46fe1f08082b65cabf73404383d9e2b17c9f068589c9b3ad661558b4e3433f033</cites><orcidid>0000-0002-8065-1342 ; 0000-0002-9402-1464 ; 0000-0003-3338-826X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186362/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186362/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30364022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Son, Chang G.</contributor><contributor>Chang G Son</contributor><creatorcontrib>Shang, Xuejun</creatorcontrib><creatorcontrib>Yan, Zechen</creatorcontrib><creatorcontrib>Zhang, Guowei</creatorcontrib><creatorcontrib>Cai, Hongcai</creatorcontrib><title>The Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Benign prostatic hyperplasia (BPH) is common among elderly men, of which inflammation, oxidative stress, proliferative, and apoptotic changes play important roles. Xialiqi (XLQ) capsule, a traditional Chinese herbal formula, is used as a potential drug in treating BPH. This study aims to evaluate the therapeutic effect of XLQ capsule on testosterone propionate- (TP-) induced BPH in rats. Fifty male Sprague-Dawley rats were randomly divided into 5 groups: sham control, BPH model, high and low dose of XLQ, and finasteride as a positive control group. All groups were treated with appropriate drugs/normal saline for 28 consecutive days. Prostate weights were recorded; histopathological changes and content of IL-8, TNF-α, DHT, SOD, MDA, caspase-3, and PCNA of the prostate were determined. Animals with BPH demonstrated significantly increased prostate weights and prostate index, higher levels of IL-8, TNF-α, DHT, MDA, and PCNA, but lower activity of SOD and reduced expression of caspase-3. After treatment with XLQ, significant reductions of prostate weights, prostate index, IL-8, TNF-α, DHT, MDA, and PCNA, increased activity of SOD, and higher level of caspase-3 were shown. The present study indicates that XLQ can effectively prevent the development of TP-induced BPH model through mechanisms of anti-inflammation, antioxidation, antiproliferation, and proapoptosis.</description><subject>Apoptosis</subject><subject>Benign</subject><subject>Cancer therapies</subject><subject>Caspase</subject><subject>Caspase-3</subject><subject>Cell growth</subject><subject>Drug dosages</subject><subject>Dutasteride</subject><subject>Finasteride</subject><subject>Genital diseases</subject><subject>Geriatrics</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>Hyperplasia</subject><subject>Hypertrophy</subject><subject>Inflammation</subject><subject>Interleukin 8</subject><subject>Laboratory animals</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Older people</subject><subject>Oxidative 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Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats</title><author>Shang, Xuejun ; Yan, Zechen ; Zhang, Guowei ; Cai, Hongcai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-46fe1f08082b65cabf73404383d9e2b17c9f068589c9b3ad661558b4e3433f033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Apoptosis</topic><topic>Benign</topic><topic>Cancer therapies</topic><topic>Caspase</topic><topic>Caspase-3</topic><topic>Cell growth</topic><topic>Drug dosages</topic><topic>Dutasteride</topic><topic>Finasteride</topic><topic>Genital diseases</topic><topic>Geriatrics</topic><topic>Health aspects</topic><topic>Herbal medicine</topic><topic>Hyperplasia</topic><topic>Hypertrophy</topic><topic>Inflammation</topic><topic>Interleukin 8</topic><topic>Laboratory animals</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine, 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Med</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Benign prostatic hyperplasia (BPH) is common among elderly men, of which inflammation, oxidative stress, proliferative, and apoptotic changes play important roles. Xialiqi (XLQ) capsule, a traditional Chinese herbal formula, is used as a potential drug in treating BPH. This study aims to evaluate the therapeutic effect of XLQ capsule on testosterone propionate- (TP-) induced BPH in rats. Fifty male Sprague-Dawley rats were randomly divided into 5 groups: sham control, BPH model, high and low dose of XLQ, and finasteride as a positive control group. All groups were treated with appropriate drugs/normal saline for 28 consecutive days. Prostate weights were recorded; histopathological changes and content of IL-8, TNF-α, DHT, SOD, MDA, caspase-3, and PCNA of the prostate were determined. Animals with BPH demonstrated significantly increased prostate weights and prostate index, higher levels of IL-8, TNF-α, DHT, MDA, and PCNA, but lower activity of SOD and reduced expression of caspase-3. After treatment with XLQ, significant reductions of prostate weights, prostate index, IL-8, TNF-α, DHT, MDA, and PCNA, increased activity of SOD, and higher level of caspase-3 were shown. The present study indicates that XLQ can effectively prevent the development of TP-induced BPH model through mechanisms of anti-inflammation, antioxidation, antiproliferation, and proapoptosis.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30364022</pmid><doi>10.1155/2018/5367814</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8065-1342</orcidid><orcidid>https://orcid.org/0000-0002-9402-1464</orcidid><orcidid>https://orcid.org/0000-0003-3338-826X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Apoptosis Benign Cancer therapies Caspase Caspase-3 Cell growth Drug dosages Dutasteride Finasteride Genital diseases Geriatrics Health aspects Herbal medicine Hyperplasia Hypertrophy Inflammation Interleukin 8 Laboratory animals Medical research Medicine Medicine, Botanic Medicine, Herbal Older people Oxidative stress Pharmaceuticals Proliferating cell nuclear antigen Propionic acid Prostate Rats Rodents Testosterone Testosterone propionate Tumor necrosis factor-α Urology |
| title | The Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats |
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