Episodic β‐cell death and dedifferentiation during diet‐induced obesity and dysglycemia in male mice

ABSTRACT Loss of functional islet '‐cell mass through cellular death or dedifferentiation is thought to lead to dysglycemia during the βrogression from obesity to ty'e 2 diabetes. To assess these 'rocesses in a mouse model of obesity, we performed measures of circulating cell‐free dif...

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Veröffentlicht in:	The FASEB journal 2018-11, Vol.32 (11), p.6150-6158
Hauptverfasser:	Tersey, Sarah A., Levasseur, Esther M., Syed, Farooq, Farb, Thomas B., Orr, Kara S., Nelson, Jennifer B., Shaw, Janice L., Bokvist, Krister, Mather, Kieren J., Mirmira, Raghavendra G.
Format:	Artikel
Sprache:	eng
Schlagworte:	cell dedifferentiation glucose intolerance islet
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