Oral-Only Linezolid-Rifampin Is Highly Effective Compared with Other Antibiotics for Periprosthetic Joint Infection: Study of a Mouse Model

The medical treatment of periprosthetic joint infection (PJI) involves prolonged systemic antibiotic courses, often with suboptimal clinical outcomes including increased morbidity and health-care costs. Oral and intravenous monotherapies and combination antibiotic regimens were evaluated in a mouse...

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Veröffentlicht in:	Journal of bone and joint surgery. American volume 2017-04, Vol.99 (8), p.656-665
Hauptverfasser:	Thompson, John M., Saini, Vikram, Ashbaugh, Alyssa G., Miller, Robert J., Ordonez, Alvaro A., Ortines, Roger V., Wang, Yu, Sterling, Robert S., Jain, Sanjay K., Miller, Lloyd S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Ceftaroline Cephalosporins - administration & dosage Cephalosporins - therapeutic use Daptomycin - administration & dosage Daptomycin - therapeutic use Disease Models, Animal Doxycycline - administration & dosage Doxycycline - therapeutic use Drug Combinations Linezolid - administration & dosage Linezolid - therapeutic use Methicillin-Resistant Staphylococcus aureus Mice Prosthesis-Related Infections - drug therapy Rifampin - administration & dosage Rifampin - therapeutic use Scientific Staphylococcal Infections - drug therapy Treatment Outcome
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