Structure of the Recombinant Neisseria gonorrhoeae Adhesin Complex Protein (rNg-ACP) and Generation of Murine Antibodies with Bactericidal Activity against Gonococci

(gonococcus [Ng]) is the causative organism of the sexually transmitted disease gonorrhoea, and no effective vaccine exists currently. In this study, the structure, biological properties, and vaccine potential of the Ng-adhesin complex protein (Ng-ACP) are presented. The crystal structure of recombi...

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Veröffentlicht in:	mSphere 2018-10, Vol.3 (5)
Hauptverfasser:	Almonacid-Mendoza, Hannia Liliana, Humbert, María Victoria, Dijokaite, Aiste, Cleary, David W, Soo, Yiwen, Hung, Miao-Chiu, Orr, Christian M, Machelett, Moritz M, Tews, Ivo, Christodoulides, Myron
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - chemistry Adjuvants Alleles Amino acids Animals Antibodies Antibodies, Bacterial - blood Antigens Antisera Bacteria Bactericidal activity Blotting, Western Chromatography Clinical trials Conservation Crystal structure Crystallography Data collection E coli Enzyme-linked immunosorbent assay Gonorrhea Gonorrhea - microbiology Gonorrhea - prevention & control Humans Immune Sera - immunology Immunoglobulins Infections Lysozyme Meningitis Meningococcal Vaccines - immunology Mice Mice, Inbred BALB C Neisseria gonorrhoeae Neisseria gonorrhoeae - genetics Neisseria gonorrhoeae - immunology Neisseria meningitidis Peptides Phosphatase Proteins R&D Rabbits Recombinant Proteins - chemistry Research & development Serum Bactericidal Antibody Assay Strains (organisms) Therapeutics and Prevention Vaccines Western blotting X-ray crystallography
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