USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization

β-catenin is a major transcriptional activator of the canonical Wnt/β-catenin signaling pathway. It is important for a series of biological processes including tissue homeostasis, and embryonic development and is involved in various human diseases. Elevated oncogenic activity of β-catenin is frequen...

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Veröffentlicht in:	Cell death and differentiation 2018-11, Vol.25 (10), p.1855-1869
Hauptverfasser:	Wu, Chenming, Luo, Kuntian, Zhao, Fei, Yin, Ping, Song, Ying, Deng, Min, Huang, Jinzhou, Chen, Yuping, Li, Lei, Lee, SeungBaek, Kim, JungJin, Zhou, Qin, Tu, Xinyi, Nowsheen, Somaira, Luo, Qifeng, Gao, Xiumei, Lou, Zhenkun, Liu, Zhongmin, Yuan, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/105 13/109 38/70 631/80/474/582 64/60 82/80 Animals Antineoplastic Agents - pharmacology Apoptosis beta Catenin - antagonists & inhibitors beta Catenin - genetics beta Catenin - metabolism Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell Cycle Analysis Cell Line, Tumor Cell migration Cell Movement - drug effects Cell proliferation Cell Survival - drug effects Cell Transformation, Neoplastic Chemoresistance Chemotherapy Drug Resistance, Neoplasm Embryogenesis Female HEK293 Cells Homeostasis Humans Leupeptins - pharmacology Life Sciences Metastases Mice Mice, Nude Neoplasms - drug therapy Neoplasms - pathology RNA Interference RNA, Small Interfering - metabolism RNA, Small Interfering - therapeutic use Signal transduction Stem Cells Transcription Tumor cell lines Tumorigenesis Ubiquitin Thiolesterase - antagonists & inhibitors Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism Ubiquitination - drug effects Wnt protein Wnt Signaling Pathway - drug effects β-Catenin
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