Chronic Myeloid Leukemia with cryptic Philadelphia translocation and extramedullary B-lymphoid blast phase as an initial presentation

Chronic Myeloid Leukemia (CML) is a clonal myeloproliferative neoplasm (MPN) characterized by the presence of a reciprocal translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34:q11), resulting in fusion of the break point cluster region (BCR) with the ABL gene, which forms an onco...

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Veröffentlicht in:	Acta bio-medica : Atenei Parmensis 2018-04, Vol.89 (3-S), p.38-44
Hauptverfasser:	Soliman, Dina S, Amer, Aliaa M, Mudawi, Deena, Al-Sabbagh, Zafar, Alkuwari, Einas, Al-Sabbagh, Ahmad, Ibrahim, Feryal, Yassin, Mohamed A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use B-Lymphocytes - pathology Biomarkers, Tumor Blast Crisis - genetics Blast Crisis - pathology Case Report Cyclophosphamide - administration & dosage Dasatinib - administration & dosage Dexamethasone - administration & dosage Doxorubicin - administration & dosage Humans In Situ Hybridization, Fluorescence Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Lymph Nodes - pathology Male Middle Aged Philadelphia Chromosome Protein Kinase Inhibitors - administration & dosage Vincristine - administration & dosage
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