The Impact of Iron Overload in Patients with Acute Leukemia and Myelodysplastic Syndrome on Hepatic and Endocrine functions
Patients with hematologic malignancies undergoing chemotherapy and requiring blood transfusion usually have an elevated serum ferritin. These findings have led to the suggestion that iron overload is common and may have deleterious effects in these patients. However, the relationship between serum f...
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| Veröffentlicht in: | Acta bio-medica : Atenei Parmensis 2018-04, Vol.89 (3-S), p.18-22 |
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| creator | Yassin, Mohamed A Soliman, Ashraf De Sanctis, Vincenzo Hmissi, Saloua M Abdulla, Mohammad A J Ekeibed, Yeslem Ismail, Omer Nashwan, Abdulqadir Soliman, Dina Almusharaf, Mohammed Hussein, Redwa |
| description | Patients with hematologic malignancies undergoing chemotherapy and requiring blood transfusion usually have an elevated serum ferritin. These findings have led to the suggestion that iron overload is common and may have deleterious effects in these patients. However, the relationship between serum ferritin and parenchymal iron overload in such patients is unknown. Therefore, we measured the liver iron content (LIC) by the FerriScan® method and investigated the liver function and some endocrine tests in 27 patients with acute leukemia (AL) or myelodysplastic syndromes (MDS). Using FerriScan® method, the normal mean LIC levels are: 4.3 ± 2.9 mg Fe/g dry weight (d.w.). In our patients, the mean serum ferritin level was 1965 ± 2428 ng/mL. In our patients, the mean total iron in the blood received by them was 7177 ± 5009 mg. In 6 out of 27 patients LIC was > 7 mg Fe/g d.w. and in 11/27 serum ferritin was > 1000 ng/ml. Measuring fasting blood glucose revealed 3/27 with diabetes mellitus and 4/27 with impaired fasting glucose (IFG). All patients had normal serum concentrations of calcium, parathormone (PTH), free thyroxine (FT4) and thyrotropin (TSH). Four patients had elevated serum alanine transferase (ALT). LIC was correlated significantly with ferritin level (r = 0.5666; P < 0.001) and the cumulative amount of iron in the transfused blood (r = 0.523; P |
| doi_str_mv | 10.23750/abm.v89i3-S.7213 |
| format | Article |
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These findings have led to the suggestion that iron overload is common and may have deleterious effects in these patients. However, the relationship between serum ferritin and parenchymal iron overload in such patients is unknown. Therefore, we measured the liver iron content (LIC) by the FerriScan® method and investigated the liver function and some endocrine tests in 27 patients with acute leukemia (AL) or myelodysplastic syndromes (MDS). Using FerriScan® method, the normal mean LIC levels are: 4.3 ± 2.9 mg Fe/g dry weight (d.w.). In our patients, the mean serum ferritin level was 1965 ± 2428 ng/mL. In our patients, the mean total iron in the blood received by them was 7177 ± 5009 mg. In 6 out of 27 patients LIC was > 7 mg Fe/g d.w. and in 11/27 serum ferritin was > 1000 ng/ml. Measuring fasting blood glucose revealed 3/27 with diabetes mellitus and 4/27 with impaired fasting glucose (IFG). All patients had normal serum concentrations of calcium, parathormone (PTH), free thyroxine (FT4) and thyrotropin (TSH). Four patients had elevated serum alanine transferase (ALT). LIC was correlated significantly with ferritin level (r = 0.5666; P < 0.001) and the cumulative amount of iron in the transfused blood (r = 0.523; P <0.001). LIC was correlated significantly with ALT (r = 0.277; P = 0.04) and fasting blood glucose (FBG) was correlated significantly with the amount of iron transfused (r = 0.52, p < 0.01) and ALT level (r = 0.44; P< 0.01). The age of patients did not correlate with LIC, FBG or ALT. In conclusions, these results contribute to our understanding of the prevalence of dysglycemia and hepatic dysfunction in relation to parenchymal iron overload in patients with hematologic malignancies undergoing chemotherapy and requiring blood transfusions.</description><identifier>ISSN: 0392-4203</identifier><identifier>EISSN: 2531-6745</identifier><identifier>DOI: 10.23750/abm.v89i3-S.7213</identifier><identifier>PMID: 29633728</identifier><language>eng</language><publisher>Italy: Mattioli 1885</publisher><subject>Acute Disease ; Adult ; Alanine Transaminase - blood ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - therapeutic use ; Biomarkers ; Blood Glucose - analysis ; Blood Transfusion ; Diabetes Mellitus - blood ; Diabetes Mellitus - etiology ; Endocrine System - physiopathology ; Ferritins - blood ; Hormones - blood ; Humans ; Hypothyroidism - etiology ; Iron - analysis ; Iron Overload - etiology ; Iron Overload - physiopathology ; Leukemia - complications ; Leukemia - drug therapy ; Leukemia - therapy ; Liver - chemistry ; Liver - physiopathology ; Myelodysplastic Syndromes - complications ; Myelodysplastic Syndromes - drug therapy ; Myelodysplastic Syndromes - therapy ; Original</subject><ispartof>Acta bio-medica : Atenei Parmensis, 2018-04, Vol.89 (3-S), p.18-22</ispartof><rights>Copyright: © 2018 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c229t-6754ccdedfe517977e798e7de9fc9cab99ae15465e647d36749413b14acf14053</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179097/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179097/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29633728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yassin, Mohamed A</creatorcontrib><creatorcontrib>Soliman, Ashraf</creatorcontrib><creatorcontrib>De Sanctis, Vincenzo</creatorcontrib><creatorcontrib>Hmissi, Saloua M</creatorcontrib><creatorcontrib>Abdulla, Mohammad A J</creatorcontrib><creatorcontrib>Ekeibed, Yeslem</creatorcontrib><creatorcontrib>Ismail, Omer</creatorcontrib><creatorcontrib>Nashwan, Abdulqadir</creatorcontrib><creatorcontrib>Soliman, Dina</creatorcontrib><creatorcontrib>Almusharaf, Mohammed</creatorcontrib><creatorcontrib>Hussein, Redwa</creatorcontrib><title>The Impact of Iron Overload in Patients with Acute Leukemia and Myelodysplastic Syndrome on Hepatic and Endocrine functions</title><title>Acta bio-medica : Atenei Parmensis</title><addtitle>Acta Biomed</addtitle><description>Patients with hematologic malignancies undergoing chemotherapy and requiring blood transfusion usually have an elevated serum ferritin. These findings have led to the suggestion that iron overload is common and may have deleterious effects in these patients. However, the relationship between serum ferritin and parenchymal iron overload in such patients is unknown. Therefore, we measured the liver iron content (LIC) by the FerriScan® method and investigated the liver function and some endocrine tests in 27 patients with acute leukemia (AL) or myelodysplastic syndromes (MDS). Using FerriScan® method, the normal mean LIC levels are: 4.3 ± 2.9 mg Fe/g dry weight (d.w.). In our patients, the mean serum ferritin level was 1965 ± 2428 ng/mL. In our patients, the mean total iron in the blood received by them was 7177 ± 5009 mg. In 6 out of 27 patients LIC was > 7 mg Fe/g d.w. and in 11/27 serum ferritin was > 1000 ng/ml. Measuring fasting blood glucose revealed 3/27 with diabetes mellitus and 4/27 with impaired fasting glucose (IFG). All patients had normal serum concentrations of calcium, parathormone (PTH), free thyroxine (FT4) and thyrotropin (TSH). Four patients had elevated serum alanine transferase (ALT). LIC was correlated significantly with ferritin level (r = 0.5666; P < 0.001) and the cumulative amount of iron in the transfused blood (r = 0.523; P <0.001). LIC was correlated significantly with ALT (r = 0.277; P = 0.04) and fasting blood glucose (FBG) was correlated significantly with the amount of iron transfused (r = 0.52, p < 0.01) and ALT level (r = 0.44; P< 0.01). The age of patients did not correlate with LIC, FBG or ALT. In conclusions, these results contribute to our understanding of the prevalence of dysglycemia and hepatic dysfunction in relation to parenchymal iron overload in patients with hematologic malignancies undergoing chemotherapy and requiring blood transfusions.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Alanine Transaminase - blood</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biomarkers</subject><subject>Blood Glucose - analysis</subject><subject>Blood Transfusion</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - etiology</subject><subject>Endocrine System - physiopathology</subject><subject>Ferritins - blood</subject><subject>Hormones - blood</subject><subject>Humans</subject><subject>Hypothyroidism - etiology</subject><subject>Iron - analysis</subject><subject>Iron Overload - etiology</subject><subject>Iron Overload - physiopathology</subject><subject>Leukemia - complications</subject><subject>Leukemia - drug therapy</subject><subject>Leukemia - therapy</subject><subject>Liver - chemistry</subject><subject>Liver - physiopathology</subject><subject>Myelodysplastic Syndromes - complications</subject><subject>Myelodysplastic Syndromes - drug therapy</subject><subject>Myelodysplastic Syndromes - therapy</subject><subject>Original</subject><issn>0392-4203</issn><issn>2531-6745</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkNtKw0AQhhdRbKl9AG9kXyB1T8lmb4RS1BYqFVqvw2Z3YheT3ZCkleDLm-IBvRqY-ecbvkHompIZ4zImtzqvZsdUOR5tZ5JRfobGLOY0SqSIz9GYcMUiwQgfoWnbupwIwlKacHKJRkwlnEuWjtHHbg94VdXadDgUeNUEjzdHaMqgLXYeP-vOge9a_O66PZ6bQwd4DYc3qJzG2lv81EMZbN_WpW47Z_C297YJFeABtIRan3qn3L23wTTOAy4O3nQu-PYKXRS6bGH6XSfo5eF-t1hG683jajFfR4Yx1Q0-sTDGgi0gplJJCVKlIC2owiijc6U00FgkMSRCWj7oK0F5ToU2BRUk5hN098WtD3kF1gw-jS6zunGVbvosaJf9n3i3z17DMUuGc0TJAXDzF_C7-fNG_gn6AnoC</recordid><startdate>20180403</startdate><enddate>20180403</enddate><creator>Yassin, Mohamed A</creator><creator>Soliman, Ashraf</creator><creator>De Sanctis, Vincenzo</creator><creator>Hmissi, Saloua M</creator><creator>Abdulla, Mohammad A J</creator><creator>Ekeibed, Yeslem</creator><creator>Ismail, Omer</creator><creator>Nashwan, Abdulqadir</creator><creator>Soliman, Dina</creator><creator>Almusharaf, Mohammed</creator><creator>Hussein, Redwa</creator><general>Mattioli 1885</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>20180403</creationdate><title>The Impact of Iron Overload in Patients with Acute Leukemia and Myelodysplastic Syndrome on Hepatic and Endocrine functions</title><author>Yassin, Mohamed A ; Soliman, Ashraf ; De Sanctis, Vincenzo ; Hmissi, Saloua M ; Abdulla, Mohammad A J ; Ekeibed, Yeslem ; Ismail, Omer ; Nashwan, Abdulqadir ; Soliman, Dina ; Almusharaf, Mohammed ; Hussein, Redwa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c229t-6754ccdedfe517977e798e7de9fc9cab99ae15465e647d36749413b14acf14053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Alanine Transaminase - blood</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biomarkers</topic><topic>Blood Glucose - analysis</topic><topic>Blood Transfusion</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - etiology</topic><topic>Endocrine System - physiopathology</topic><topic>Ferritins - blood</topic><topic>Hormones - blood</topic><topic>Humans</topic><topic>Hypothyroidism - etiology</topic><topic>Iron - analysis</topic><topic>Iron Overload - etiology</topic><topic>Iron Overload - physiopathology</topic><topic>Leukemia - complications</topic><topic>Leukemia - drug therapy</topic><topic>Leukemia - therapy</topic><topic>Liver - chemistry</topic><topic>Liver - physiopathology</topic><topic>Myelodysplastic Syndromes - complications</topic><topic>Myelodysplastic Syndromes - drug therapy</topic><topic>Myelodysplastic Syndromes - therapy</topic><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yassin, Mohamed A</creatorcontrib><creatorcontrib>Soliman, Ashraf</creatorcontrib><creatorcontrib>De Sanctis, Vincenzo</creatorcontrib><creatorcontrib>Hmissi, Saloua M</creatorcontrib><creatorcontrib>Abdulla, Mohammad A J</creatorcontrib><creatorcontrib>Ekeibed, Yeslem</creatorcontrib><creatorcontrib>Ismail, Omer</creatorcontrib><creatorcontrib>Nashwan, Abdulqadir</creatorcontrib><creatorcontrib>Soliman, Dina</creatorcontrib><creatorcontrib>Almusharaf, Mohammed</creatorcontrib><creatorcontrib>Hussein, Redwa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta bio-medica : Atenei Parmensis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yassin, Mohamed A</au><au>Soliman, Ashraf</au><au>De Sanctis, Vincenzo</au><au>Hmissi, Saloua M</au><au>Abdulla, Mohammad A J</au><au>Ekeibed, Yeslem</au><au>Ismail, Omer</au><au>Nashwan, Abdulqadir</au><au>Soliman, Dina</au><au>Almusharaf, Mohammed</au><au>Hussein, Redwa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Impact of Iron Overload in Patients with Acute Leukemia and Myelodysplastic Syndrome on Hepatic and Endocrine functions</atitle><jtitle>Acta bio-medica : Atenei Parmensis</jtitle><addtitle>Acta Biomed</addtitle><date>2018-04-03</date><risdate>2018</risdate><volume>89</volume><issue>3-S</issue><spage>18</spage><epage>22</epage><pages>18-22</pages><issn>0392-4203</issn><eissn>2531-6745</eissn><abstract>Patients with hematologic malignancies undergoing chemotherapy and requiring blood transfusion usually have an elevated serum ferritin. These findings have led to the suggestion that iron overload is common and may have deleterious effects in these patients. However, the relationship between serum ferritin and parenchymal iron overload in such patients is unknown. Therefore, we measured the liver iron content (LIC) by the FerriScan® method and investigated the liver function and some endocrine tests in 27 patients with acute leukemia (AL) or myelodysplastic syndromes (MDS). Using FerriScan® method, the normal mean LIC levels are: 4.3 ± 2.9 mg Fe/g dry weight (d.w.). In our patients, the mean serum ferritin level was 1965 ± 2428 ng/mL. In our patients, the mean total iron in the blood received by them was 7177 ± 5009 mg. In 6 out of 27 patients LIC was > 7 mg Fe/g d.w. and in 11/27 serum ferritin was > 1000 ng/ml. Measuring fasting blood glucose revealed 3/27 with diabetes mellitus and 4/27 with impaired fasting glucose (IFG). All patients had normal serum concentrations of calcium, parathormone (PTH), free thyroxine (FT4) and thyrotropin (TSH). Four patients had elevated serum alanine transferase (ALT). LIC was correlated significantly with ferritin level (r = 0.5666; P < 0.001) and the cumulative amount of iron in the transfused blood (r = 0.523; P <0.001). LIC was correlated significantly with ALT (r = 0.277; P = 0.04) and fasting blood glucose (FBG) was correlated significantly with the amount of iron transfused (r = 0.52, p < 0.01) and ALT level (r = 0.44; P< 0.01). The age of patients did not correlate with LIC, FBG or ALT. In conclusions, these results contribute to our understanding of the prevalence of dysglycemia and hepatic dysfunction in relation to parenchymal iron overload in patients with hematologic malignancies undergoing chemotherapy and requiring blood transfusions.</abstract><cop>Italy</cop><pub>Mattioli 1885</pub><pmid>29633728</pmid><doi>10.23750/abm.v89i3-S.7213</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Acute Disease Adult Alanine Transaminase - blood Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Biomarkers Blood Glucose - analysis Blood Transfusion Diabetes Mellitus - blood Diabetes Mellitus - etiology Endocrine System - physiopathology Ferritins - blood Hormones - blood Humans Hypothyroidism - etiology Iron - analysis Iron Overload - etiology Iron Overload - physiopathology Leukemia - complications Leukemia - drug therapy Leukemia - therapy Liver - chemistry Liver - physiopathology Myelodysplastic Syndromes - complications Myelodysplastic Syndromes - drug therapy Myelodysplastic Syndromes - therapy Original |
| title | The Impact of Iron Overload in Patients with Acute Leukemia and Myelodysplastic Syndrome on Hepatic and Endocrine functions |
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