Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response

Although virulence mechanisms targeting gamma interferon (IFN-γ)-induced cell-autonomous antiparasitic immunity have been extensively characterized in mice, the virulence mechanisms in humans remain uncertain, partly because cell-autonomous immune responses against differ markedly between mice and h...

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Veröffentlicht in:	mBio 2018-10, Vol.9 (5)
Hauptverfasser:	Bando, Hironori, Lee, Youngae, Sakaguchi, Naoya, Pradipta, Ariel, Ma, Ji Su, Tanaka, Shun, Cai, Yihong, Liu, Jianfa, Shen, Jilong, Nishikawa, Yoshifumi, Sasai, Miwa, Yamamoto, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Protozoan - immunology Cell Line Coculture Techniques CRISPR-Cas Systems Hepatocytes - drug effects Hepatocytes - immunology Hepatocytes - parasitology Host-Microbe Biology Host-Parasite Interactions - immunology Humans Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Interferon-gamma - pharmacology Interleukin-1beta - metabolism Mice Mice, Inbred C57BL Monocytes - immunology Monocytes - parasitology Nitric Oxide Synthase Type II - immunology NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Protozoan Proteins - immunology Toxoplasma - immunology Toxoplasma - pathogenicity Virulence Factors - immunology
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