Overlapping motifs on the herpes viral proteins ICP27 and ORF57 mediate interactions with the mRNA export adaptors ALYREF and UIF

The TREX complex mediates the passage of bulk cellular mRNA export to the nuclear export factor TAP/NXF1 via the export adaptors ALYREF or UIF, which appear to act in a redundant manner. TREX complex recruitment to nascent RNA is coupled with 5′ capping, splicing and polyadenylation. Therefore to fa...

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Veröffentlicht in:	Scientific reports 2018-10, Vol.8 (1), p.15005-12, Article 15005
Hauptverfasser:	Tunnicliffe, Richard B., Tian, Xiaochen, Storer, Joanna, Sandri-Goldin, Rozanne M., Golovanov, Alexander P.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 14/35 631/1647/245/2225 631/45/612/1230 631/45/612/1256 82/1 82/6 Active Transport, Cell Nucleus - genetics Binding sites Binding Sites - genetics Cell Nucleus - genetics Exodeoxyribonucleases - genetics Gene Expression Regulation, Viral - genetics Herpes viruses Herpesvirus 1, Human - genetics Herpesvirus 1, Human - pathogenicity Herpesvirus 8, Human - genetics Herpesvirus 8, Human - pathogenicity Host-Pathogen Interactions - genetics Humanities and Social Sciences Humans Immediate-Early Proteins - genetics Introns - genetics Magnetic resonance spectroscopy multidisciplinary NMR Nuclear magnetic resonance Nuclear Magnetic Resonance, Biomolecular Nuclear Proteins - genetics Nuclear transport Nucleocytoplasmic Transport Proteins - genetics Phosphoproteins - genetics Polyadenylation Protein Binding - genetics RNA Transport - genetics RNA, Messenger - genetics RNA-Binding Proteins - genetics Science Science (multidisciplinary) Splicing Transcription Factors - genetics Viral Regulatory and Accessory Proteins - genetics
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